Aligning mouse models of asthma to human endotypes of disease

TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice

(2014) L. McKinley et al.   JOURNAL OF IMMUNOLOGY

From phenotypes to endotypes to asthma treatment

(2013) Ioana O. Agache   Current Opinion in Allergy and Clinical Immunology

The Many Faces of Asthma in Obesity

(2013) O. Sideleva et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Transcription Factors GATA-3 and ROR t Are Important for Determining the Phenotype of Allergic Airway Inflammation in a Murine Model of Asthma

(2013) S. Ano et al.   JOURNAL OF IMMUNOLOGY

How Cytokine Networks Fuel Inflammation: Toward a cytokine-based disease taxonomy

(2013) Georg Schett et al.   NATURE MEDICINE

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential Effects of Rapamycin and Dexamethasone in Mouse Models of Established Allergic Asthma

(2013) Elizabeth M. Mushaben et al.   PLoS One

The Endogenous Th17 Response in NO2-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer

(2013) Rebecca A. Martin et al.   PLoS One

IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation

(2013) Dawn Catherine Newcomb et al.   THORAX

IL-17 in lung disease: friend or foe?

(2013) Hui-Leng Tan et al.   THORAX

Untangling asthma phenotypes and endotypes

(2012) I. Agache et al.   ALLERGY

A Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic

(2012) Kelly Wong McGrath et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nebulized Anti–IL-13 Monoclonal Antibody Fab′ Fragment Reduces Allergen-Induced Asthma

(2012) Jonathan Hacha et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Stratified approaches to the treatment of asthma

(2012) Stephen T. Holgate   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Winter sports athletes: long-term effects of cold air exposure

(2012) Malcolm Sue-Chu   BRITISH JOURNAL OF SPORTS MEDICINE

Severe asthma: from characteristics to phenotypes to endotypes

(2012) S. Wenzel   CLINICAL AND EXPERIMENTAL ALLERGY

Strategies for Molecular Classification of Asthma Using Bipartite Network Analysis of Cytokine Expression

(2012) Regina R. Pillai et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Innate lymphoid cells: critical regulators of allergic inflammation and tissue repair in the lung

(2012) Laurel A Monticelli et al.   CURRENT OPINION IN IMMUNOLOGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

(2012) Guiquan Jia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

(2012) Monique A.M. Willart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling

(2012) J Zhao et al.   Mucosal Immunology

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Genetic Interactions between Chromosomes 11 and 18 Contribute to Airway Hyperresponsiveness in Mice

(2012) Caroline M. Ferreira et al.   PLoS One

Cigarette smoke dissociates inflammation and lung remodeling in OVA-sensitized and challenged mice

(2012) Deborah C. Hizume et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?

(2012) Rakesh K. Kumar et al.   Frontiers in Physiology

The Th17 Pathway and Inflammatory Diseases of the Intestines, Lungs, and Skin

(2011) Casey T. Weaver et al.   Annual Review of Pathology-Mechanisms of Disease

The increasing challenge of discovering asthma drugs

(2011) Kevin Mullane   BIOCHEMICAL PHARMACOLOGY

TH17 cells in asthma and inflammation

(2011) Shean J. Aujla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma

(2011) H. Hirata et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Animal models of asthma: value, limitations and opportunities for alternative approaches

(2011) Anthony M. Holmes et al.   DRUG DISCOVERY TODAY

Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome

(2011) Jan Lötvall et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Severe asthma: Advances in current management and future therapy

(2011) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity

(2011) Hye Young Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A

(2011) Ana Paula Moreira et al.   JOURNAL OF CLINICAL INVESTIGATION

Invariant NKT cells are required for airway inflammation induced by environmental antigens

(2011) Gerhard Wingender et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

The naive airway hyperresponsiveness of the A/J mouse is Kit-mediated

(2011) E. Cozzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Models and approaches to understand the role of airway remodelling in disease

(2011) Robin J. McAnulty   PULMONARY PHARMACOLOGY & THERAPEUTICS

Insights into asthmatic airway remodelling through murine models

(2011) SABA AL HEIALY et al.   RESPIROLOGY

Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares

(2010) Ning Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Apolipoprotein E Negatively Regulates House Dust Mite–induced Asthma via a Low-Density Lipoprotein Receptor–mediated Pathway

(2010) Xianglan Yao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TH17 Cells in Asthma and COPD

(2010) John F. Alcorn et al.   Annual Review of Physiology

Glucocorticosteroids: current and future directions

(2010) Peter J Barnes   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy and Safety of Subcutaneous Omalizumab vs Placebo as Add-on Therapy to Corticosteroids for Children and Adults With Asthma

(2010) Gustavo J. Rodrigo et al.   CHEST

Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes

(2010) Annette T. Hastie et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A novel subset of CD4+TH2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma

(2010) Yui-Hsi Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Overexpression of Heparin-Binding Epidermal Growth Factor Is Responsible for Th17-Induced Airway Remodeling in an Experimental Asthma Model

(2010) Q. Wang et al.   JOURNAL OF IMMUNOLOGY

Early Immunological Response to German Cockroach Frass Exposure Induces a Th2/Th17 Environment

(2010) Kristen Page et al.   Journal of Innate Immunity

Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance

(2010) Christopher S. Stevenson et al.   PHARMACOLOGY & THERAPEUTICS

Neutralisation of Interleukin-13 in Mice Prevents Airway Pathology Caused by Chronic Exposure to House Dust Mite

(2010) Kate L. Tomlinson et al.   PLoS One

Allergic Sensitization through the Airway Primes Th17-dependent Neutrophilia and Airway Hyperresponsiveness

(2009) Rhonda H. Wilson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

(2009) Wendy C. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

Th17 Immunity in Patients with Allergic Asthma

(2009) Yang Zhao et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

The outer wall of small airways is a major site of remodeling in fatal asthma

(2009) Marisa Dolhnikoff et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13

(2009) Rui He et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TH17-associated cytokines (IL-17A and IL-17F) in severe asthma

(2009) Wisam Al-Ramli et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pathogenesis of Steroid-Resistant Airway Hyperresponsiveness: Interaction between IFN-  and TLR4/MyD88 Pathways

(2009) M. Yang et al.   JOURNAL OF IMMUNOLOGY

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

(2009) Hamida Hammad et al.   NATURE MEDICINE

IL-23 and Th17 Cells Enhance Th2-Cell–mediated Eosinophilic Airway Inflammation in Mice

(2008) Hidefumi Wakashin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cluster Analysis and Clinical Asthma Phenotypes

(2008) Pranab Haldar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma

(2008) Louise S. Harrington et al.   FASEB JOURNAL

Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17

(2008) Muriel Pichavant et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

(2008) Aurelien Trompette et al.   NATURE

Repeated instillations of Dermatophagoides farinae into the airways can induce Th2-dependent airway hyperresponsiveness, eosinophilia and remodeling in mice

(2007) Keiko Wakahara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY