Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits

A probe in the connection between inflammation, cognition and suicide

(2018) Ricardo Cáceda et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

(2018) Mark A. Petersen et al.   NATURE REVIEWS NEUROSCIENCE

Brain perivascular macrophages: characterization and functional roles in health and disease

(2017) Giuseppe Faraco et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Elevation of p11 in lateral habenula mediates depression-like behavior

(2017) J-S Seo et al.   MOLECULAR PSYCHIATRY

Blood-Brain Barrier Dysfunction Precedes Cognitive Decline and Neurodegeneration in Diabetic Insulin Resistant Mouse Model: An Implication for Causal Link

(2017) Ryusuke Takechi et al.   Frontiers in Aging Neuroscience

Effects of acute systemic inflammation on the interplay between sad mood and affective cognition

(2017) Sven Benson et al.   Translational Psychiatry

The Mast Cell, Contact, and Coagulation System Connection in Anaphylaxis

(2017) Mar Guilarte et al.   Frontiers in Immunology

Acute hypothalamo-pituitary-adrenal axis response to LPS-induced endotoxemia: expression pattern of kinin type B1 and B2 receptors

(2016) Fatimunnisa Qadri et al.   BIOLOGICAL CHEMISTRY

Reflexes in Immunity

(2016) Kevin J. Tracey   CELL

Chronic cerebral hypoperfusion induces memory deficits and facilitates Aβ generation in C57BL/6J mice

(2016) Lingxi Wang et al.   EXPERIMENTAL NEUROLOGY

The complement and contact activation systems: partnership in pathogenesis beyond angioedema

(2016) Berhane Ghebrehiwet et al.   IMMUNOLOGICAL REVIEWS

Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain

(2016) Fengjiao Wu et al.   Journal of Neuroinflammation

The Choroid Plexus in Healthy and Diseased Brain

(2016) Charanjit Kaur et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cognition and psychopathology in first-episode psychosis: are they related to inflammation?

(2016) B. Cabrera et al.   PSYCHOLOGICAL MEDICINE

Hereditary angioedema with dominant cerebral symptoms finally leading to chronic disability

(2015) Anetta Lasek-Bal et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Recombinant human C1 esterase inhibitor for the treatment of hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE)

(2015) Geetika Sabharwal et al.   Expert Review of Clinical Immunology

Chronic Hypertension Leads to Neurodegeneration in the TgSwDI Mouse Model of Alzheimer’s DiseaseNovelty and Significance

(2015) Anna Kruyer et al.   HYPERTENSION

Plasma contact system activation drives anaphylaxis in severe mast cell–mediated allergic reactions

(2015) Anna Sala-Cunill et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TMEM119 marks a subset of microglia in the human brain

(2015) Jun-ichi Satoh et al.   NEUROPATHOLOGY

Activation of the factor XII-driven contact system in Alzheimer’s disease patient and mouse model plasma

(2015) Daria Zamolodchikov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

(2015) Jae Kyu Ryu et al.   Nature Communications

Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice

(2015) Steven Biesmans et al.   Biomed Research International

Inhibition of Vascular Permeability by Antisense-Mediated Inhibition of Plasma Kallikrein and Coagulation Factor 12

(2015) Gourab Bhattacharjee et al.   Nucleic Acid Therapeutics

In acute experimental autoimmune encephalomyelitis, infiltrating macrophages are immune activated, whereas microglia remain immune suppressed

(2014) I. D. Vainchtein et al.   GLIA

Low-Level Laser Therapy Ameliorates Disease Progression in a Mouse Model of Alzheimer’s Disease

(2014) Dorit Farfara et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation

(2014) Christiane Albert-Weissenberger et al.   Frontiers in Cellular Neuroscience

Depression and anxiety in patients with hereditary angioedema

(2013) Andrew S. Fouche et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice

(2013) Steven Biesmans et al.   MEDIATORS OF INFLAMMATION

Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair

(2013) Anat London et al.   Frontiers in Cellular Neuroscience

Neuroinflammation: A Common Pathway in CNS Diseases as Mediated at the Blood-Brain Barrier

(2012) Michelle A. Erickson et al.   NEUROIMMUNOMODULATION

Exceptional stroke-like episodes in a patient with type I autosomal angioedema

(2012) I. Bonnaud et al.   NEUROLOGY

C1-Inhibitor Protects From Brain Ischemia-Reperfusion Injury by Combined Antiinflammatory and Antithrombotic Mechanisms

(2012) Nadine Heydenreich et al.   STROKE

Neurovascular Coupling in Cognitive Impairment Associated With Diabetes Mellitus

(2011) Masaki Mogi et al.   CIRCULATION JOURNAL

Cross-talk between the complement and the kinin system in vascular permeability

(2011) Fleur Bossi et al.   IMMUNOLOGY LETTERS

Migraine-like Headache in a Patient with Complement 1 Inhibitor Deficient Hereditary Angioedema

(2011) Jin-Young Chung et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease

(2011) Paula Grammas   Journal of Neuroinflammation

Blood–Brain Barrier Permeability Abnormalities in Vascular Cognitive Impairment

(2011) Saeid Taheri et al.   STROKE

Cognitive dysfunction with aging and the role of inflammation

(2011) Arthur A. Simen et al.   Therapeutic Advances in Chronic Disease

Sensory circumventricular organs in health and disease

(2010) Sílvia Sisó et al.   ACTA NEUROPATHOLOGICA

γ-Secretase component presenilin is important for microglia β-amyloid clearance

(2010) Dorit Farfara et al.   ANNALS OF NEUROLOGY

TGF-β1 affects endothelial cell interaction with macrophages and T cells leading to the development of cerebrovascular amyloidosis

(2010) Ronen Weiss et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibition of Bradykinin Receptor B1 Protects Mice from Focal Brain Injury by Reducing Blood–Brain Barrier Leakage and Inflammation

(2010) Furat Raslan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Trafficking of immune cells in the central nervous system

(2010) Emma H. Wilson et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Characterization of the Recombinant Human C1 Inhibitor Serpin Domain: Insights into Heparin Binding

(2010) V. Rossi et al.   JOURNAL OF IMMUNOLOGY

Blood–brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE

(2010) Jami Bennett et al.   JOURNAL OF NEUROIMMUNOLOGY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Neisseria meningitidis Induces Brain Microvascular Endothelial Cell Detachment from the Matrix and Cleavage of Occludin: A Role for MMP-8

(2010) Alexandra Schubert-Unkmeir et al.   PLoS Pathogens

Defining “Neuroinflammation”

(2009) James P. O'Callaghan et al.   Annals of the New York Academy of Sciences

Factor XII–independent cleavage of high-molecular-weight kininogen by prekallikrein and inhibition by C1 inhibitor

(2009) Kusumam Joseph et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CNS Infiltration of Peripheral Immune Cells: D-Day for Neurodegenerative Disease?

(2009) Kavon Rezai-Zadeh et al.   Journal of Neuroimmune Pharmacology

Inflammation: A bridge between postoperative cognitive dysfunction and Alzheimer’s disease

(2009) Zhonghua Hu et al.   MEDICAL HYPOTHESES

C1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progress

(2009) Massimo Cugno et al.   TRENDS IN MOLECULAR MEDICINE

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

Bradykinin induces matrix metalloproteinase-9 expression and cell migration through a PKC-δ-dependent ERK/Elk-1 pathway in astrocytes

(2008) Hsi-Lung Hsieh et al.   GLIA

Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease

(2008) D. Farfara et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Perivascular Spaces and the Two Steps to Neuroinflammation

(2008) Trevor Owens et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Immune cell entry into the central nervous system: Involvement of adhesion molecules and chemokines

(2008) Britta Engelhardt   JOURNAL OF THE NEUROLOGICAL SCIENCES

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON