Benzodifurans for biomedical applications: BZ4, a selective anti-proliferative and anti-amyloid lead compound

A Natural Benzofuran from the Patagonic Aleurodiscus vitellinus Fungus has Potent Neuroprotective Properties on a Cellular Model of Amyloid-β Peptide Toxicity

(2018) Mariela González-Ramírez et al.   JOURNAL OF ALZHEIMERS DISEASE

Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities

(2018) Antonio Carella et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Brazilin inhibits fibrillogenesis of human islet amyloid polypeptide, disassembles mature fibrils, and alleviates cytotoxicity

(2017) Jingjing Guo et al.   RSC Advances

Synthesis and biological evaluation of a novel Amadori compound

(2016) Giovanni N. Roviello et al.   AMINO ACIDS

A long lifetime luminescent iridium(iii) complex chemosensor for the selective switch-on detection of Al3+ ions

(2016) Wanhe Wang et al.   CHEMICAL COMMUNICATIONS

A first-in-class and a fished out anticancer platinum compound: cis-[PtCl2(NH3)2] and cis-[PtI2(NH3)2] compared for their reactivity towards DNA model systems

(2016) Domenica Musumeci et al.   DALTON TRANSACTIONS

A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells

(2016) Katia Pane et al.   FEBS Journal

Nucleic acid binding and other biomedical properties of artificial oligolysines

(2016) Giovanni N. Roviello et al.   International Journal of Nanomedicine

Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide

(2016) G. N. Roviello et al.   RSC Advances

Synthetic approaches to nucleopeptides containing all four nucleobases, and nucleic acid-binding studies on a mixed-sequence nucleo-oligolysine

(2016) Giovanni N. Roviello et al.   RSC Advances

Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1–42 induced neurotoxicity and memory impairment

(2016) Paula Maria Quaglio Bellozi et al.   Scientific Reports

Benzodifuran Derivatives as Potential Antiproliferative Agents: Possible Correlation between Their Bioactivity and Aggregation Properties

(2016) Domenica Musumeci et al.   ChemPlusChem

Guanine-based amphiphiles: synthesis, ion transport properties and biological activity

(2015) Domenica Musumeci et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease

(2015) K. Rajasekhar et al.   CHEMICAL COMMUNICATIONS

Inhibition of protein aggregation and amyloid formation by small molecules

(2015) Andrew J Doig et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Interaction of anticancer Ru(iii) complexes with single stranded and duplex DNA model systems

(2015) Domenica Musumeci et al.   DALTON TRANSACTIONS

Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions

(2015) Concetta Di Natale et al.   FASEB JOURNAL

Chitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate Amyloid β-Mediated Neurotoxicity

(2015) Xueling Dai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cancer Cell Death Induced by the Intracellular Self-Assembly of an Enzyme-Responsive Supramolecular Gelator

(2015) Akiko Tanaka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting copper in cancer therapy: ‘Copper That Cancer’

(2015) Delphine Denoyer et al.   Metallomics

In vivo imaging and characterization of [18F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET

(2015) Caterina Vicidomini et al.   NUCLEAR MEDICINE AND BIOLOGY

Development of New Two-Dimensional Small Molecules Based on Benzodifuran for Efficient Organic Solar Cells

(2014) Zhengkun Du et al.   Chemistry-An Asian Journal

Synthesis and antimicrobial evaluation of amide derivatives of benzodifuran-2-carboxylic acid

(2014) Jigar N. Soni et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An oligonucleotide-based label-free luminescent switch-on probe for RNA detection utilizing a G-quadruplex-selective iridium(iii) complex

(2014) Dik-Lung Ma et al.   Nanoscale

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

3-Acyl-5-hydroxybenzofuran derivatives as potential anti-estrogen breast cancer agents: A combined experimental and theoretical investigation

(2013) Xiao-Yan Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An oligonucleotide-based switch-on luminescent probe for the detection of kanamycin in aqueous solution

(2012) Ka-Ho Leung et al.   SENSORS AND ACTUATORS B-CHEMICAL

Dansyl-anthracene dyads for ratiometric fluorescence recognition of Cu2+

(2011) Kuljit Kaur et al.   DALTON TRANSACTIONS

Synthesis and characterization of a novel ester-based nucleoamino acid for the assembly of aromatic nucleopeptides for biomedical applications

(2011) Giovanni N. Roviello et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nucleolipid nanovectors as molecular carriers for potential applications in drug delivery

(2011) Luca Simeone et al.   Molecular BioSystems

Irvalec Inserts into the Plasma Membrane Causing Rapid Loss of Integrity and Necrotic Cell Death in Tumor Cells

(2011) José M. Molina-Guijarro et al.   PLoS One

A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease

(2011) K. Broersen et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

Nanofabrication techniques for controlled drug-release devices

(2010) Lei Chen et al.   Nanomedicine

Complete Phenotypic Recovery of an Alzheimer's Disease Model by a Quinone-Tryptophan Hybrid Aggregation Inhibitor

(2010) Roni Scherzer-Attali et al.   PLoS One

Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity

(2009) Giovanni N. Roviello et al.   AMINO ACIDS

Aβ Oligomers and Fibrillar Aggregates Induce Different Apoptotic Pathways in LAN5 Neuroblastoma Cell Cultures

(2009) Pasquale Picone et al.   BIOPHYSICAL JOURNAL

CyPLOS: a new family of synthetic ionophores

(2009) Sabina Licen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

(2008) V. Serra et al.   CANCER RESEARCH

Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer’s Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush

(2008) Michela Rosini et al.   JOURNAL OF MEDICINAL CHEMISTRY