The role of IL-17 in systemic lupus erythematosus and its potential as a therapeutic target

CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease

(2018) Kayaho Maeda et al.   JOURNAL OF CLINICAL INVESTIGATION

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

(2018) Zhi-Wei Lai et al.   LANCET

A case of refractory lupus nephritis complicated by psoriasis vulgaris that was controlled with secukinumab

(2018) Y Satoh et al.   LUPUS

Metabolism as a Target for Modulation in Autoimmune Diseases

(2018) Nick Huang et al.   TRENDS IN IMMUNOLOGY

Blockade of Treg Cell Differentiation and Function by the Interleukin-21-Mechanistic Target of Rapamycin Axis Via Suppression of Autophagy in Patients With Systemic Lupus Erythematosus

(2018) Hiroshi Kato et al.   Arthritis & Rheumatology

Efficacy and safety of ustekinumab, an IL-12 and IL-23 inhibitor, in patients with active systemic lupus erythematosus: results of a multicentre, double-blind, phase 2, randomised, controlled study

(2018) Ronald F van Vollenhoven et al.   LANCET

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

(2018) Michelle Rosenzwajg et al.   ANNALS OF THE RHEUMATIC DISEASES

Calcium/calmodulin-dependent protein kinase 4 promotes GLUT1-dependent glycolysis in systemic lupus erythematosus

(2018) Tomohiro Koga et al.   Arthritis & Rheumatology

Novel Treatments in Lupus

(2018) Milena Vukelic et al.   Frontiers in Immunology

Lupus nephritis and B-cell targeting therapy

(2017) Matthias Cassia et al.   Expert Review of Clinical Immunology

IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus

(2017) Hong Dai et al.   JOURNAL OF IMMUNOLOGY

The role of CaMK4 in immune responses

(2017) Tomohiro Koga et al.   Modern Rheumatology

Review: Metabolic Control of Immune System Activation in Rheumatic Diseases

(2017) Andras Perl   Arthritis & Rheumatology

Targeting the RhoA-ROCK pathway to reverse T-cell dysfunction in SLE

(2016) Cristina Rozo et al.   ANNALS OF THE RHEUMATIC DISEASES

Tacrolimus use in lupus nephritis: A systematic review and meta-analysis

(2016) Jennifer Hannah et al.   AUTOIMMUNITY REVIEWS

Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

(2016) Romain Banchereau et al.   CELL

Update on Lupus Nephritis

(2016) Salem Almaani et al.   Clinical Journal of the American Society of Nephrology

Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration

(2016) E. G. Gentry et al.   JOURNAL OF NEUROSCIENCE

Phosphatase PP2A is requisite for the function of regulatory T cells

(2016) Sokratis A Apostolidis et al.   NATURE IMMUNOLOGY

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

(2016) Jing He et al.   NATURE MEDICINE

ICER is requisite for Th17 differentiation

(2016) Nobuya Yoshida et al.   Nature Communications

Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function

(2016) Kunihiro Ichinose et al.   Arthritis & Rheumatology

Calcium/Calmodulin-Dependent Kinase IV Facilitates the Recruitment of Interleukin-17-Producing Cells to Target Organs Through the CCR6/CCL20 Axis in Th17 Cell-Driven Inflammatory Diseases

(2016) Tomohiro Koga et al.   Arthritis & Rheumatology

Risk of End-Stage Renal Disease in Patients With Lupus Nephritis, 1971-2015: A Systematic Review and Bayesian Meta-Analysis

(2016) Maria G. Tektonidou et al.   Arthritis & Rheumatology

IL-17 and IL-23 in lupus nephritis - association to histopathology and response to treatment

(2015) Agneta Zickert et al.   BMC IMMUNOLOGY

Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activity

(2015) Roba M. Talaat et al.   CYTOKINE

Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity

(2015) Patrick R. Burkett et al.   JOURNAL OF CLINICAL INVESTIGATION

T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity

(2015) Vaishali R. Moulton et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials

(2015) Christopher E M Griffiths et al.   LANCET

Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial

(2015) Iain B McInnes et al.   LANCET

Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis

(2015) Dominique Baeten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis

(2015) Mark Lebwohl et al.   NEW ENGLAND JOURNAL OF MEDICINE

The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis: Table 1

(2015) Takashi Kurita et al.   RHEUMATOLOGY

KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3+regulatory T cells in MRL/lprmice

(2014) Tomohiro Koga et al.   AUTOIMMUNITY

The role of T cells in systemic lupus erythematosus

(2014) Christine Konya et al.   CURRENT OPINION IN RHEUMATOLOGY

CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance

(2014) Tomohiro Koga et al.   JOURNAL OF CLINICAL INVESTIGATION

PP2A Dephosphorylates Elf-1 and Determines the Expression of CD3  and FcR  in Human Systemic Lupus Erythematosus T Cells

(2014) Y.-T. Juang et al.   JOURNAL OF IMMUNOLOGY

Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

(2014) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

Methylation Status of CpG Islands Flanking a cAMP Response Element Motif on the Protein Phosphatase 2Ac  Promoter Determines CREB Binding and Activity

(2014) K. Sunahori et al.   JOURNAL OF IMMUNOLOGY

IL-2 Protects Lupus-Prone Mice from Multiple End-Organ Damage by Limiting CD4−CD8−IL-17–Producing T Cells

(2014) Masayuki Mizui et al.   JOURNAL OF IMMUNOLOGY

Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4-CD8- Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus

(2014) H. Kato et al.   JOURNAL OF IMMUNOLOGY

Brodalumab, an Anti-IL17RA Monoclonal Antibody, in Psoriatic Arthritis

(2014) Philip J. Mease et al.   NEW ENGLAND JOURNAL OF MEDICINE

Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials

(2014) Richard G. Langley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ethnic specificity of lupus-associated loci identified in a genome-wide association study in Korean women

(2013) Hye-Soon Lee et al.   ANNALS OF THE RHEUMATIC DISEASES

HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE

(2013) Tiffany N Caza et al.   ANNALS OF THE RHEUMATIC DISEASES

Enhanced Rho-Associated Protein Kinase Activation in Patients With Systemic Lupus Erythematosus

(2013) Josephine Isgro et al.   ARTHRITIS AND RHEUMATISM

Protein Phosphatase 2A Enables Expression of Interleukin 17 (IL-17) through Chromatin Remodeling

(2013) Sokratis A. Apostolidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cAMP-responsive Element Modulator α (CREMα)trans-Represses the Transmembrane Glycoprotein CD8 and Contributes to the Generation of CD3+CD4−CD8−T Cells in Health and Disease

(2013) Christian M. Hedrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cAMP Responsive Element Modulator (CREM) α Mediates Chromatin Remodeling ofCD8during the Generation of CD3+CD4−CD8−T Cells

(2013) Christian M. Hedrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Target of Rapamycin Activation Triggers IL-4 Production and Necrotic Death of Double-Negative T Cells in Patients with Systemic Lupus Erythematosus

(2013) Z.-W. Lai et al.   JOURNAL OF IMMUNOLOGY

Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial

(2013) Iain B McInnes et al.   LANCET

Clinical associations of serum interleukin-17 in systemic lupus erythematosus

(2013) Fabien B Vincent et al.   ARTHRITIS RESEARCH & THERAPY

Treatment with Anti-Interleukin 23 Antibody Ameliorates Disease in Lupus-Prone Mice

(2013) Vasileios C. Kyttaris et al.   Biomed Research International

IL-17-producing γδ T cells and innate lymphoid cells

(2012) Caroline E. Sutton et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cutting Edge: Protein Phosphatase 2A Confers Susceptibility to Autoimmune Disease through an IL-17-Dependent Mechanism

(2012) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses IL-2 Production and Regulatory T Cell Activity in Lupus

(2012) T. Koga et al.   JOURNAL OF IMMUNOLOGY

Gene expression of cytokines (TNF-α, IFN-γ), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosus

(2012) A Rana et al.   LUPUS

Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice

(2012) RA Stirzaker et al.   LUPUS

Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

(2012) Inmoo Rhee et al.   NATURE IMMUNOLOGY

cAMP response element modulator   controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus

(2012) C. M. Hedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CREMα overexpression decreases IL-2 production, induces a TH17 phenotype and accelerates autoimmunity

(2012) Ralph Lippe et al.   Journal of Molecular Cell Biology

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Successful Treatment of Subacute Lupus Erythematosus With Ustekinumab

(2011) Aieska De Souza   ARCHIVES OF DERMATOLOGY

Copy number variations of interleukin-17F, interleukin-21, and interleukin-22 are associated with systemic lupus erythematosus

(2011) Bo Yu et al.   ARTHRITIS AND RHEUMATISM

Th17 cells in systemic lupus erythematosus share functional features with Th17 cells from normal bone marrow and peripheral tissues

(2011) Ana Henriques et al.   CLINICAL RHEUMATOLOGY

Targeting lymphocyte signaling pathways as a therapeutic approach to systemic lupus erythematosus

(2011) Vasileios C. Kyttaris et al.   CURRENT OPINION IN RHEUMATOLOGY

cAMP-responsive Element Modulator (CREM)α Protein Induces Interleukin 17A Expression and Mediates Epigenetic Alterations at the Interleukin-17A Gene Locus in Patients with Systemic Lupus Erythematosus

(2011) Thomas Rauen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Calcium/Calmodulin-Dependent Protein Kinase Type IV Is Essential for Mesangial Cell Proliferation and Lupus Nephritis

(2011) K. Ichinose et al.   JOURNAL OF IMMUNOLOGY

IL-17-producing T cells in lupus nephritis

(2011) SA Apostolidis et al.   LUPUS

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Induction of PP2A B , a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus

(2011) J. C. Crispin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-23: A Promising Therapeutic Target for Systemic Lupus Erythematosus

(2010) Rui-Xue Leng et al.   ARCHIVES OF MEDICAL RESEARCH

Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activity

(2010) José C. Crispín et al.   ARTHRITIS AND RHEUMATISM

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

(2010) Jonathan D. Powell et al.   IMMUNITY

Transcriptional Activation of the cAMP-responsive Modulator Promoter in Human T Cells Is Regulated by Protein Phosphatase 2A-mediated Dephosphorylation of SP-1 and Reflects Disease Activity in Patients with Systemic Lupus Erythematosus

(2010) Yuang-Taung Juang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity

(2010) Linda A. Lieberman et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice

(2010) Partha S. Biswas et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: IL-23 Receptor Deficiency Prevents the Development of Lupus Nephritis in C57BL/6-lpr/lpr Mice

(2010) V. C. Kyttaris et al.   JOURNAL OF IMMUNOLOGY

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Interleukin 2 and systemic lupus erythematosus

(2009) Diana Gómez-Martín et al.   AUTOIMMUNITY REVIEWS

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus

(2009) J. Y. Humrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus

(2009) B. C.-H. Kwan et al.   RHEUMATOLOGY

Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-α–producing antigen-presenting cells

(2008) Bing Yan et al.   ARTHRITIS AND RHEUMATISM

Ca2+/Calmodulin-dependent Protein Kinases

(2008) M. T. Swulius et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity

(2008) Chun Kwok Wong et al.   CLINICAL IMMUNOLOGY

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

(2008) Wenjun Ouyang et al.   IMMUNITY

Structural Basis for CD44 Recognition by ERM Proteins

(2008) Tomoyuki Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

(2008) Craig L Leonardi et al.   LANCET

Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller

(2008) Luigi Racioppi et al.   TRENDS IN IMMUNOLOGY