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Title
TYRO3: A potential therapeutic target in cancer
Authors
Keywords
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Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 244, Issue 2, Pages 83-99
Publisher
SAGE Publications
Online
2019-02-02
DOI
10.1177/1535370219828195
References
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Note: Only part of the references are listed.- Tyro3-mediated phosphorylation of ACTN4 at tyrosines is FAK-dependent and decreases susceptibility to cleavage by m-Calpain
- (2018) Hanshuang Shao et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
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- (2018) Cunzhen Shi et al. Journal of Hematology & Oncology
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- (2018) Kyota Fujita et al. Nature Communications
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- (2018) Jichen Zhao et al. JOURNAL OF MEDICINAL CHEMISTRY
- A microRNA-7/growth arrest specific 6/TYRO3 axis regulates the growth and invasiveness of sorafenib-resistant cells in human hepatocellular carcinoma
- (2017) Tasnuva D. Kabir et al. HEPATOLOGY
- Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression
- (2017) Canan Kasikara et al. MOLECULAR CANCER RESEARCH
- MerTK inhibition by RXDX-106 in MerTK activated gastric cancer cell lines
- (2017) Jung Eun Kim et al. Oncotarget
- Gas6 Promotes Oligodendrogenesis and Myelination in the Adult Central Nervous System and After Lysolecithin-Induced Demyelination
- (2016) Salman Goudarzi et al. ASN Neuro
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- (2016) Peng Ning et al. ENDOCRINE-RELATED CANCER
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- (2016) Mohd Firdaus Che Mat et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer
- (2016) Peter B. Alexander et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting TYRO3 inhibits epithelial–mesenchymal transition and increases drug sensitivity in colon cancer
- (2016) C-W Chien et al. ONCOGENE
- The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
- (2016) P. Y. Chan et al. SCIENCE
- Metformin: A candidate for the treatment of gynecological tumors based on drug repositioning
- (2016) HARUKO IRIE et al. Oncology Letters
- TAM receptors Tyro3 and Mer as novel targets in colorectal cancer
- (2016) Robin Schmitz et al. Oncotarget
- Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors
- (2015) S. Sinha et al. CLINICAL CANCER RESEARCH
- Metformin targets Axl and Tyro3 receptor tyrosine kinases to inhibit cell proliferation and overcome chemoresistance in ovarian cancer cells
- (2015) NAM-YI KIM et al. INTERNATIONAL JOURNAL OF ONCOLOGY
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- (2015) YAN DUAN et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Significant blockade of multiple receptor tyrosine kinases by MGCD516 (Sitravatinib), a novel small molecule inhibitor, shows potent anti-tumor activity in preclinical models of sarcoma
- (2015) Parag P. Patwardhan et al. Oncotarget
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- (2015) CHUHEE LEE Molecular Medicine Reports
- MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme
- (2015) Kristina H. Knubel et al. Oncotarget
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- (2015) Yusuke Shiozawa et al. NEOPLASIA
- Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer
- (2014) SOICHIRO HONJO et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer
- (2014) Vijayalekshmi Nair et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation
- (2014) Wen-I Tsou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics
- (2014) Sharad Sharma et al. Molecular Oncology
- The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
- (2014) Magdalena Paolino et al. NATURE
- Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma
- (2013) Pu-xiang Chen et al. Annals of Diagnostic Pathology
- Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients
- (2013) Ju Han et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Gas6 induces cancer cell migration and epithelial–mesenchymal transition through upregulation of MAPK and Slug
- (2013) Yunhee Lee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Evaluation of Tyro3 Expression, Gas6-Mediated Akt Phosphorylation, and the Impact of Anti-Tyro3 Antibodies in Melanoma Cell Lines
- (2013) Stephen J. Demarest et al. BIOCHEMISTRY
- Identification of potent Yes1 kinase inhibitors using a library screening approach
- (2013) Paresma R. Patel et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Higher bone marrow LGALS3 expression is an independent unfavorable prognostic factor for overall survival in patients with acute myeloid leukemia
- (2013) C.-L. Cheng et al. BLOOD
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- (2013) Floor A.M. Duijkers et al. GENE
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- (2013) Jennifer Schlegel et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2013) Weihe Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2013) S P Whitman et al. LEUKEMIA
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- (2013) Keith M. Giles et al. MOLECULAR CANCER THERAPEUTICS
- Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia
- (2013) A B Lee-Sherick et al. ONCOGENE
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- (2013) Kathryn A. Tworkoski et al. Pigment Cell & Melanoma Research
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- (2013) Russell S. Taichman et al. PLoS One
- Biology of the TAM Receptors
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- (2013) L N Brandao et al. Blood Cancer Journal
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- Cancer and Innate Immune System Interactions
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- (2012) R M A Linger et al. ONCOGENE
- Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme
- (2012) Y Wang et al. ONCOGENE
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- (2012) J D Paccez et al. ONCOGENE
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- (2012) A N Rettew et al. Oncogenesis
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- (2011) Chien-Hsing Lee et al. ANNALS OF SURGICAL ONCOLOGY
- Novel and selective spiroindoline-based inhibitors of sky kinase
- (2011) Noel A. Powell et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Imatinib is receptive to a collaboration
- (2011) N. J. Donato BLOOD
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- (2011) I. Ben Sahra et al. CANCER RESEARCH
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- (2011) Flip H. Jansen et al. JOURNAL OF PROTEOME RESEARCH
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- (2011) Huang Guo et al. Molecular Neurodegeneration
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- (2011) A E Sayan et al. ONCOGENE
- Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors
- (2011) L. V. Sequist et al. Science Translational Medicine
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- (2011) Alexis Mollard et al. ACS Medicinal Chemistry Letters
- The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy
- (2010) A. K. Ghosh et al. BLOOD
- Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma
- (2010) R. Liu et al. BLOOD
- Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma
- (2010) Xianzhou Song et al. CANCER
- AXL Is an Essential Factor and Therapeutic Target for Metastatic Ovarian Cancer
- (2010) E. B. Rankin et al. CANCER RESEARCH
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- (2010) Stuart Thomson et al. CLINICAL & EXPERIMENTAL METASTASIS
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- (2010) Nora B Caberoy et al. EMBO JOURNAL
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- (2010) Z. Zhong et al. JOURNAL OF NEUROSCIENCE
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- (2010) G. Mudduluru et al. MOLECULAR CANCER RESEARCH
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- (2009) S. Loges et al. BLOOD
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- (2009) A. Gustafsson et al. CLINICAL CANCER RESEARCH
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- (2009) Yusuke Shiozawa et al. EXPERIMENTAL HEMATOLOGY
- Unconventional secretion of tubby and tubby-like protein 1
- (2009) Nora B. Caberoy et al. FEBS LETTERS
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- (2009) Gretchen M. Schroeder et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2009) Y Li et al. ONCOGENE
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- (2009) Anna Gustafsson et al. PLoS One
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- (2009) S. Zhu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2009) Ewa Sierko et al. THROMBOSIS RESEARCH
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- (2008) Walter Nickel et al. Annual Review of Cell and Developmental Biology
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- (2008) Sirwan M. Hadad et al. BREAST CANCER RESEARCH AND TREATMENT
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- (2008) O Mc Cormack et al. BRITISH JOURNAL OF CANCER
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- (2008) Vitor M. Faça et al. PLoS One
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