The role of chronic kidney disease-associated dysbiosis in cardiovascular disease

Deoxycholic Acid, a Metabolite of Circulating Bile Acids, and Coronary Artery Vascular Calcification in CKD

(2018) Anna Jovanovich et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Metabolic products of the intestinal microbiome and extremes of atherosclerosis

(2018) Chrysi Bogiatzi et al.   ATHEROSCLEROSIS

High fiber dietary and sodium butyrate attenuate experimental autoimmune hepatitis through regulation of immune regulatory cells and intestinal barrier

(2018) En-De Hu et al.   CELLULAR IMMUNOLOGY

Gut microbial diversity is associated with lower arterial stiffness in women

(2018) Cristina Menni et al.   EUROPEAN HEART JOURNAL

Effect of Bariatric Surgery on CKD Risk

(2018) Allon N. Friedman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease

(2018) Tao Yang et al.   Nature Reviews Nephrology

Intestinal barrier disruption and dysregulated mucosal immunity contribute to kidney fibrosis in chronic kidney disease

(2018) Jihyun Yang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Gut Microbiota, Hypertension and Chronic kidney Disease: recent advances

(2018) Antonio Sircana et al.   PHARMACOLOGICAL RESEARCH

Microbiota metabolites: Pivotal players of cardiovascular damage in chronic kidney disease

(2018) Carmela Cosola et al.   PHARMACOLOGICAL RESEARCH

The Relationship between Frequently Used Glucose-Lowering Agents and Gut Microbiota in Type 2 Diabetes Mellitus

(2018) You Lv et al.   Journal of Diabetes Research

Targeting FXR and FGF19 to Treat Metabolic Diseases—Lessons Learned From Bariatric Surgery

(2018) Nadejda Bozadjieva et al.   DIABETES

Microbiome–Metabolomics Analysis of the Impacts of Long-Term Dietary Advanced-Glycation-End-Product Consumption on C57BL/6 Mouse Fecal Microbiota and Metabolites

(2018) Wanting Qu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

T84 monolayers are superior to Caco-2 as a model system of colonocytes

(2017) Sarah Devriese et al.   HISTOCHEMISTRY AND CELL BIOLOGY

FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity

(2017) Xiaoxin X. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

p -cresol sulfate and indoxyl sulfate: some clouds are gathering in the uremic toxin sky

(2017) Pieter Evenepoel et al.   KIDNEY INTERNATIONAL

Results of the HEMO Study suggest that p -cresol sulfate and indoxyl sulfate are not associated with cardiovascular outcomes

(2017) Tariq Shafi et al.   KIDNEY INTERNATIONAL

Manipulating the gut microbiome to decrease uremic toxins

(2017) Rabi Yacoub et al.   KIDNEY INTERNATIONAL

Microbiome perturbation by oral vancomycin reduces plasma concentration of two gut-derived uremic solutes, indoxyl sulfate and p-cresyl sulfate, in end-stage renal disease

(2017) Lama Nazzal et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The gut microbiome in atherosclerotic cardiovascular disease

(2017) Zhuye Jie et al.   Nature Communications

p-Cresyl Sulfate

(2017) Tessa Gryp et al.   Toxins

Association Study of Gut Flora in Coronary Heart Disease through High-Throughput Sequencing

(2017) Li Cui et al.   Biomed Research International

Gastric Bypass Surgery Produces a Durable Reduction in Cardiovascular Disease Risk Factors and Reduces the Long‐Term Risks of Congestive Heart Failure

(2017) Peter N. Benotti et al.   Journal of the American Heart Association

Gut microbiota dysbiosis contributes to the development of hypertension

(2017) Jing Li et al.   Microbiome

CVD and Oxidative Stress

(2017) Karla Cervantes Gracia et al.   Journal of Clinical Medicine

Advanced glycation end products dietary restriction effects on bacterial gut microbiota in peritoneal dialysis patients; a randomized open label controlled trial

(2017) Rabi Yacoub et al.   PLoS One

Impaired renal function and dysbiosis of gut microbiota contribute to increased trimethylamine-N-oxide in chronic kidney disease patients

(2017) Kai-Yu Xu et al.   Scientific Reports

Coronary Plaque Characterization Assessed by Optical Coherence Tomography and Plasma Trimethylamine-N-oxide Levels in Patients With Coronary Artery Disease

(2016) Qiang Fu et al.   AMERICAN JOURNAL OF CARDIOLOGY

Trends in Prevalence of Chronic Kidney Disease in the United States

(2016) Daniel Murphy et al.   ANNALS OF INTERNAL MEDICINE

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Hypertension-Linked Pathophysiological Alterations in the GutNovelty and Significance

(2016) Monica M. Santisteban et al.   CIRCULATION RESEARCH

Inflammation and Progression of CKD: The CRIC Study

(2016) R. L. Amdur et al.   Clinical Journal of the American Society of Nephrology

Fatty Liver and Chronic Kidney Disease: Novel Mechanistic Insights and Therapeutic Opportunities

(2016) Giovanni Musso et al.   DIABETES CARE

Adult microbiota-deficient mice have distinct dendritic morphological changes: differential effects in the amygdala and hippocampus

(2016) Pauline Luczynski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease

(2016) Frank J. Gonzalez et al.   GASTROENTEROLOGY

Influence of Roux-en-Y gastric bypass on plasma bile acid profiles: a comparative study between rats, pigs and humans

(2016) V Spinelli et al.   INTERNATIONAL JOURNAL OF OBESITY

Microbiota-Derived Phenylacetylglutamine Associates with Overall Mortality and Cardiovascular Disease in Patients with CKD

(2016) R. Poesen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Gut microbiota in renal physiology: focus on short-chain fatty acids and their receptors

(2016) Jennifer L. Pluznick   KIDNEY INTERNATIONAL

Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a “pro-inflammatory” state associated with atherosclerosis and autoimmunity

(2016) S.C. Gominak   MEDICAL HYPOTHESES

Inflammatory processes in cardiovascular disease: a route to targeted therapies

(2016) Neil Ruparelia et al.   Nature Reviews Cardiology

The influence of renal transplantation on retained microbial–human co-metabolites

(2016) Ruben Poesen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Heat-treated high-fat diet modifies gut microbiota and metabolic markers in apoe−/− mice

(2016) Nittaya Marungruang et al.   Nutrition & Metabolism

Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41

(2016) Niranjana Natarajan et al.   PHYSIOLOGICAL GENOMICS

The Effect of Diet and Exercise on Intestinal Integrity and Microbial Diversity in Mice

(2016) Sara C. Campbell et al.   PLoS One

Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health

(2016) David Ríos-Covián et al.   Frontiers in Microbiology

Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction

(2016) Susanne H. Karbach et al.   Journal of the American Heart Association

GPR41 and GPR43 in Obesity and Inflammation – Protective or Causative?

(2016) Zhiwei Ang et al.   Frontiers in Immunology

Intestinal microbiota in pediatric patients with end stage renal disease: a Midwest Pediatric Nephrology Consortium study

(2016) Janice Crespo-Salgado et al.   Microbiome

Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis

(2016) Nathan R. Hill et al.   PLoS One

Elderly patients have an altered gut-brain axis regardless of the presence of cirrhosis

(2016) Jasmohan S. Bajaj et al.   Scientific Reports

Probiotics in obstetrics and gynaecology

(2015) Christopher Griffin   AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart FailureCLINICAL PERSPECTIVE

(2015) Chelsea L. Organ et al.   Circulation-Heart Failure

Gut Dysbiosis Is Linked to HypertensionNovelty and Significance

(2015) Tao Yang et al.   HYPERTENSION

Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells

(2015) Carolina Iraporda et al.   IMMUNOBIOLOGY

Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice

(2015) Zhibo Gai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advanced glycation end-products: modifiable environmental factors profoundly mediate insulin resistance

(2015) Mona S. Ottum et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Metabolomic study of carotid–femoral pulse-wave velocity in women

(2015) Cristina Menni et al.   JOURNAL OF HYPERTENSION

Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion

(2015) V. Andrade-Oliveira et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effect of diet-derived advanced glycation end products on inflammation

(2015) Nicole J. Kellow et al.   NUTRITION REVIEWS

Free Levels of Selected Organic Solutes and Cardiovascular Morbidity and Mortality in Hemodialysis Patients: Results from the Retained Organic Solutes and Clinical Outcomes (ROSCO) Investigators

(2015) Tariq Shafi et al.   PLoS One

Iron Modulates Butyrate Production by a Child Gut Microbiota In Vitro

(2015) A. Dostal et al.   mBio

Guest Editorial

(2015) Katherine E. Gregory   Advances in Neonatal Care

Meta-Analysis of the Associations of p-Cresyl Sulfate (PCS) and Indoxyl Sulfate (IS) with Cardiovascular Events and All-Cause Mortality in Patients with Chronic Renal Failure

(2015) Cheng-Jui Lin et al.   PLoS One

Expansion of Urease- and Uricase-Containing, Indole- and p-Cresol-Forming and Contraction of Short-Chain Fatty Acid-Producing Intestinal Microbiota in ESRD

(2014) Jakk Wong et al.   AMERICAN JOURNAL OF NEPHROLOGY

Inflammation and Cardiovascular Disease: From Pathogenesis to Therapeutic Target

(2014) Enrica Golia et al.   Current Atherosclerosis Reports

Probiotics and Pregnancy

(2014) Luisa F. Gomez Arango et al.   Current Diabetes Reports

The bile acid TGR5 membrane receptor: From basic research to clinical application

(2014) Henri Duboc et al.   DIGESTIVE AND LIVER DISEASE

Gut Bacterial Translocation May Aggravate Microinflammation in Hemodialysis Patients

(2014) Kehui Shi et al.   DIGESTIVE DISEASES AND SCIENCES

Microbiota and diabetes: an evolving relationship

(2014) Herbert Tilg et al.   GUT

Effect of Probiotics on Blood Pressure

(2014) Saman Khalesi et al.   HYPERTENSION

Randomized Placebo-Controlled EPPIC Trials of AST-120 in CKD

(2014) G. Schulman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

What Would You Like to Eat, Mr CKD Microbiota? A Mediterranean Diet, please!

(2014) Eustacchio Montemurno et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Dual Activation of the Bile Acid Nuclear Receptor FXR and G-Protein-Coupled Receptor TGR5 Protects Mice against Atherosclerosis

(2014) Shinobu Miyazaki-Anzai et al.   PLoS One

Gut microbiota and GLP-1

(2014) Amandine Everard et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Protein-Bound Molecules: A Large Family With a Bad Character

(2014) Tammy L. Sirich et al.   SEMINARS IN NEPHROLOGY

Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

(2014) Chiara Degirolamo et al.   Cell Reports

Exploration of novel predictive markers in rat plasma of the early stages of chronic renal failure

(2013) Toshihiro Kobayashi et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Angiotensin II–Induced Vascular Dysfunction Depends on Interferon-γ–Driven Immune Cell Recruitment and Mutual Activation of Monocytes and NK-Cells

(2013) Sabine Kossmann et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intestinal microbiota, diet and health

(2013) Susan E. Power et al.   BRITISH JOURNAL OF NUTRITION

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Estimating Deaths From Cardiovascular Disease: A Review of Global Methodologies of Mortality Measurement

(2013) Neha Jadeja Pagidipati et al.   CIRCULATION

Renal Clearance and Intestinal Generation of p-Cresyl Sulfate and Indoxyl Sulfate in CKD

(2013) R. Poesen et al.   Clinical Journal of the American Society of Nephrology

The Gut Microbiome, Kidney Disease, and Targeted Interventions

(2013) A. Ramezani et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cognitive decline, dietary factors and gut–brain interactions

(2013) Barbara Caracciolo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Uremia and chronic kidney disease: The role of the gut microflora and therapies with pro- and prebiotics

(2013) Luis Vitetta et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Long-Term Stability of the Human Gut Microbiota

(2013) J. J. Faith et al.   SCIENCE

Uremic Plasma Impairs Barrier Function and Depletes the Tight Junction Protein Constituents of Intestinal Epithelium

(2012) Nosratola D. Vaziri et al.   AMERICAN JOURNAL OF NEPHROLOGY

Role of Urea in Intestinal Barrier Dysfunction and Disruption of Epithelial Tight Junction in Chronic Kidney Disease

(2012) Nosratola D. Vaziri et al.   AMERICAN JOURNAL OF NEPHROLOGY

Advanced Glycation End Products and Diabetic Cardiovascular Disease

(2012) Anand Prasad et al.   Cardiology in Review

Association between Albuminuria, Kidney Function, and Inflammatory Biomarker Profile in CKD in CRIC

(2012) J. Gupta et al.   Clinical Journal of the American Society of Nephrology

CKD impairs barrier function and alters microbial flora of the intestine

(2012) Nosratola D. Vaziri   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

p-Cresyl Sulfate Promotes Insulin Resistance Associated with CKD

(2012) L. Koppe et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chronic kidney disease alters intestinal microbial flora

(2012) Nosratola D. Vaziri et al.   KIDNEY INTERNATIONAL

Oral Supplementation of Butyrate Reduces Mucositis and Intestinal Permeability Associated with 5-Fluorouracil Administration

(2012) Talita Mayra Ferreira et al.   LIPIDS

Urinary phenylacetylglutamine as dosing biomarker for patients with urea cycle disorders

(2012) M. Mokhtarani et al.   MOLECULAR GENETICS AND METABOLISM

A framework for human microbiome research

(2012)   NATURE

Gut bacterial translocation is associated with microinflammation in end-stage renal disease patients

(2012) FEIQIAN WANG et al.   NEPHROLOGY

p-Cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells

(2012) C.-Y. Sun et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Uremic Toxins Induce Kidney Fibrosis by Activating Intrarenal Renin–Angiotensin–Aldosterone System Associated Epithelial-to-Mesenchymal Transition

(2012) Chiao-Yin Sun et al.   PLoS One

Microbial Regulation of Glucose Metabolism and Cell-Cycle Progression in Mammalian Colonocytes

(2012) Dallas R. Donohoe et al.   PLoS One

Symptomatic atherosclerosis is associated with an altered gut metagenome

(2012) Fredrik H. Karlsson et al.   Nature Communications

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Fermentation in the Human Large Intestine

(2011) George T. Macfarlane et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Disintegration of colonic epithelial tight junction in uremia: a likely cause of CKD-associated inflammation

(2011) Nosratola D. Vaziri et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney

(2011) Y. Miyamoto et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Serum levels of total p-cresylsulphate are associated with angiographic coronary atherosclerosis severity in stable angina patients with early stage of renal failure

(2010) Chao-Ping Wang et al.   ATHEROSCLEROSIS

Farnesoid X Receptor Activation Prevents the Development of Vascular Calcification in ApoE −/− Mice With Chronic Kidney Disease

(2010) Shinobu Miyazaki-Anzai et al.   CIRCULATION RESEARCH

Circulating Endotoxemia: A Novel Factor in Systemic Inflammation and Cardiovascular Disease in Chronic Kidney Disease

(2010) C. W. McIntyre et al.   Clinical Journal of the American Society of Nephrology

p-Cresol and Cardiovascular Risk in Mild-to-Moderate Kidney Disease

(2010) B. K. I. Meijers et al.   Clinical Journal of the American Society of Nephrology

Indoxyl Sulfate-Induced Endothelial Dysfunction in Patients with Chronic Kidney Disease via an Induction of Oxidative Stress

(2010) M. Yu et al.   Clinical Journal of the American Society of Nephrology

Advanced glycation end-products and the kidney

(2010) Martin Busch et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Epidemiology of hypertensive kidney disease

(2010) Suneel Udani et al.   Nature Reviews Nephrology

p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease

(2010) I.-W. Wu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Human oral, gut, and plaque microbiota in patients with atherosclerosis

(2010) O. Koren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypertension in Early-Stage Kidney Disease: An Update From the Kidney Early Evaluation Program (KEEP)

(2009) Rigas Kalaitzidis et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

p-Cresyl Sulfate and Indoxyl Sulfate in Hemodialysis Patients

(2009) B. K. I. Meijers et al.   Clinical Journal of the American Society of Nephrology

Interleukin 17 Promotes Angiotensin II–Induced Hypertension and Vascular Dysfunction

(2009) Meena S. Madhur et al.   HYPERTENSION

Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR−/−and apoE−/−mice

(2009) Helen B. Hartman et al.   JOURNAL OF LIPID RESEARCH

Bile acids as regulatory molecules

(2009) Phillip B. Hylemon et al.   JOURNAL OF LIPID RESEARCH

A Review of Albumin Binding in CKD

(2008) Björn K.I. Meijers et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Antiatherosclerotic effect of farnesoid X receptor

(2008) Andrea Mencarelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endotoxemia is Related to Systemic Inflammation and Atherosclerosis in Peritoneal Dialysis Patients

(2008) C.-C. Szeto et al.   Clinical Journal of the American Society of Nephrology

Cardiorenal Syndrome

(2008) Claudio Ronco et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis

(2008) Harry J. Flint et al.   NATURE REVIEWS MICROBIOLOGY

AST-120 Treatment in Pre-Dialysis Period Affects the Prognosis in Patients on Hemodialysis

(2008) Haruhiko Ueda et al.   RENAL FAILURE