Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease

Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate

(2017) Weronika Rzepnikowska et al.   HUMAN MOLECULAR GENETICS

Endoplasmic reticulum–mitochondria junction is required for iron homeostasis

(2017) Yong Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Vps13p–Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion

(2017) Mithu De et al.   JOURNAL OF CELL BIOLOGY

Quantitative high-content imaging identifies novel regulators of Neo1 trafficking at endosomes

(2017) Lauren E. Dalton et al.   MOLECULAR BIOLOGY OF THE CELL

Drosophila Vps13 Is Required for Protein Homeostasis in the Brain

(2017) Jan J. Vonk et al.   PLoS One

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

(2016) Suzanne Lesage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model

(2016) Ana Mesquita et al.   Autophagy

Exploring the power of yeast to model aging and age-related neurodegenerative disorders

(2016) Ana V. Oliveira et al.   BIOGERONTOLOGY

Yeast Vps13 promotes mitochondrial function and is localized at membrane contact sites

(2016) Jae-Sook Park et al.   MOLECULAR BIOLOGY OF THE CELL

Using HHsearch to tackle proteins of unknown function: A pilot study with PH domains

(2016) David R. Fidler et al.   TRAFFIC

Identification of VPS13C as a Galectin-12-Binding Protein That Regulates Galectin-12 Protein Stability and Adipogenesis

(2016) Ri-Yao Yang et al.   PLoS One

TipC and the chorea-acanthocytosis protein VPS13A regulate autophagy inDictyosteliumand human HeLa cells

(2015) Sandra Muñoz-Braceras et al.   Autophagy

Chorein Sensitive Arrangement of Cytoskeletal Architecture

(2015) Sabina Honisch et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies

(2015) J.-P. Lasserre et al.   Disease Models & Mechanisms

Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity

(2015) Sandra Tenreiro et al.   HUMAN MOLECULAR GENETICS

The vacuolar protein sorting genes in insects: A comparative genome view

(2015) Zhaofei Li et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

ER–mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13

(2015) Alexander B. Lang et al.   JOURNAL OF CELL BIOLOGY

VPS13D Gene Variant Is Associated with Altered IL-6 Production and Mortality in Septic Shock

(2015) Taka-aki Nakada et al.   Journal of Innate Immunity

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Chorein Sensitive Dopamine Release from Pheochromocytoma (PC12) Cells

(2015) Sabina Honisch et al.   NEUROSIGNALS

A Conserved Function in Phosphatidylinositol Metabolism for Mammalian Vps13 Family Proteins

(2015) Jae-Sook Park et al.   PLoS One

De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability

(2014) S E McCarthy et al.   MOLECULAR PSYCHIATRY

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

Comparative Proteomics Analysis of Gastric Cancer Stem Cells

(2014) Tamami Morisaki et al.   PLoS One

Chorein, the protein responsible for chorea-acanthocytosis, interacts with β-adducin and β-actin

(2013) Nari Shiokawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chorein Sensitivity of Actin Polymerization, Cell Shape and Mechanical Stiffness of Vascular Endothelial Cells

(2013) Ioana Alesutan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Contemporary, yeast-based approaches to understanding human genetic variation

(2013) Maitreya J Dunham et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Identification of SHRUBBY, a SHORT-ROOT and SCARECROW interacting protein that controls root growth and radial patterning

(2013) K. Koizumi et al.   DEVELOPMENT

Chorein sensitivity of cytoskeletal organization and degranulation of platelets

(2013) Eva-Maria Schmidt et al.   FASEB JOURNAL

Cohen syndrome is associated with major glycosylation defects

(2013) Laurence Duplomb et al.   HUMAN MOLECULAR GENETICS

The Benefits of Humanized Yeast Models to Study Parkinson’s Disease

(2013) V. Franssens et al.   Oxidative Medicine and Cellular Longevity

Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates  -Synuclein Toxicity in Neurons

(2013) D. F. Tardiff et al.   SCIENCE

Retromer-mediated endosomal protein sorting: all WASHed up!

(2013) Matthew N.J. Seaman et al.   TRENDS IN CELL BIOLOGY

Inheritance of the fittest mitochondria in yeast

(2013) Jason D. Vevea et al.   TRENDS IN CELL BIOLOGY

Chorein-sensitive polymerization of cortical actin and suicidal cell death in chorea-acanthocytosis

(2012) Michael Föller et al.   FASEB JOURNAL

A Loss-of-Function Variant in the Human Histidyl-tRNA Synthetase (HARS) Gene is Neurotoxic In Vivo

(2012) Aimée Vester et al.   HUMAN MUTATION

VPS13 regulates membrane morphogenesis during sporulation in Saccharomyces cerevisiae

(2012) Jae-Sook Park et al.   JOURNAL OF CELL SCIENCE

Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity

(2011) L. De Franceschi et al.   BLOOD

Clinical variability of genetic isolates of Cohen syndrome

(2011) S Douzgou et al.   CLINICAL GENETICS

Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

(2011) R. J. Strawbridge et al.   DIABETES

The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals

(2011) N. Grarup et al.   DIABETOLOGIA

Vacuolar Protein Sorting Protein 13A, TtVPS13A, Localizes to the Tetrahymena thermophila Phagosome Membrane and Is Required for Efficient Phagocytosis

(2011) Haresha S. Samaranayake et al.   EUKARYOTIC CELL

Sporulation in the Budding YeastSaccharomyces cerevisiae

(2011) Aaron M. Neiman   GENETICS

Frameshift mutations of vacuolar protein sorting genes in gastric and colorectal cancers with microsatellite instability

(2011) Chang Hyeok An et al.   HUMAN PATHOLOGY

Cohen Syndrome-associated Protein, COH1, Is a Novel, Giant Golgi Matrix Protein Required for Golgi Integrity

(2011) Wenke Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Genetic Variants in ADCY5, GIPR, GCKR and VPS13C on Early Impairment of Glucose and Insulin Metabolism in Children

(2011) Jan Windholz et al.   PLoS One

A yeast-based assay identifies drugs active against human mitochondrial disorders

(2011) E. Couplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas

(2011) Toru Furukawa et al.   Scientific Reports

Reconstitution and Protein Composition Analysis of Endocytic Actin Patches

(2010) Alphée Michelot et al.   CURRENT BIOLOGY

A Saccharomyces cerevisiae strain unable to store neutral lipids is tolerant to oxidative stress induced by α-synuclein

(2010) Yves Y. Sere et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

Pathway-Based Identification of Biomarkers for Targeted Therapeutics: Personalized Oncology with PI3K Pathway Inhibitors

(2010) J. N. Andersen et al.   Science Translational Medicine

Differential requirements for actin during yeast and mammalian endocytosis

(2009) Soheil Aghamohammadzadeh et al.   NATURE CELL BIOLOGY