Hydrophobic bile acid apoptosis is regulated by sphingosine-1-phosphate receptor 2 in rat hepatocytes and human hepatocellular carcinoma cells

Autophagy and apoptosis in liver injury

(2015) Kewei Wang   CELL CYCLE

Tauroursodeoxycholate Protects Rat Hepatocytes from Bile Acid-Induced Apoptosis via β1-Integrin- and Protein Kinase A-Dependent Mechanisms

(2015) Annika Sommerfeld et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice

(2015) Su-Yeon Lee et al.   HEPATOLOGY

Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression

(2015) Masayuki Nagahashi et al.   HEPATOLOGY

Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis

(2015) Benjamin L. Woolbright et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Protein kinase Cδ protects against bile acid apoptosis by suppressing proapoptotic JNK and BIM pathways in human and rat hepatocytes

(2014) Cynthia R. L. Webster et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2

(2014) Runping Liu et al.   HEPATOLOGY

Beyond intestinal soap—bile acids in metabolic control

(2014) Folkert Kuipers et al.   Nature Reviews Endocrinology

Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis

(2013) Golnar Karimian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Bile Acids Modulate Signaling by Functional Perturbation of Plasma Membrane Domains

(2013) Yong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological hypoxia prevents bile salt-induced apoptosis in human and rat hepatocytes

(2013) Simon Hohenester et al.   LIVER INTERNATIONAL

Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential

(2012) Gerald Ulrich Denk et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Sphingosine Kinase-2 Suppresses Inflammation and Attenuates Graft Injury after Liver Transplantation in Rats

(2012) Qinlong Liu et al.   PLoS One

Angiotensin II Protects Primary Rat Hepatocytes against Bile Salt-Induced Apoptosis

(2012) Golnar Karimian et al.   PLoS One

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase

(2011) A. Johnston et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice

(2011) Tsutomu Matsubara et al.   HEPATOLOGY

Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes

(2011) Elaine Studer et al.   HEPATOLOGY

Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia–reperfusion

(2011) Yanjun Shi et al.   JOURNAL OF HEPATOLOGY

Dexamethasone decreases cholestatic liver injury via inhibition of intrinsic pathway with simultaneous enhancement of mitochondrial biogenesis

(2011) Mao-Meng Tiao et al.   STEROIDS

Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells

(2010) Simon Hohenester et al.   JOURNAL OF HEPATOLOGY

Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via Gαi-protein-coupled receptors and the AKT pathway

(2010) Risheng Cao et al.   JOURNAL OF LIPID RESEARCH

cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 β/α in rat hepatocytes

(2009) Anna Gates et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Causal role of oxidative stress in liver preconditioning by thyroid hormone in rats

(2008) Virginia Fernández et al.   FREE RADICAL BIOLOGY AND MEDICINE

Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes

(2008) Dorothée Walter et al.   HEPATOLOGY

Bile Acid-induced Apoptosis in Hepatocytes Is Caspase-6-dependent

(2008) Christian Rust et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2

(2008) Hitoshi Ikeda et al.   JOURNAL OF LIPID RESEARCH

Thyroid hormone effect in human hepatocytes

(2008) Eliana A. Miler et al.   REDOX REPORT