Article
Nutrition & Dietetics
Hui Liu, Wu Luo, Jiazheng Liu, Xincong Kang, Jianming Yan, Tingting Zhang, Lan Yang, Lu Shen, Dongbo Liu
Summary: This study found that honokiol can improve glucose metabolism disorders and oxidative stress in hepatocytes by activating AMPK. This provides new insights into the use of honokiol as a potential drug for the prevention and treatment of diabetes and its complications.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Tao Bao, Naymul Karim, Huihui Ke, Jitbanjong Tangpong, Wei Chen
Summary: In this study, wax apple polysaccharide (WAP) was isolated from wax apple and its protective effect against ethyl carbamate (EC)-induced oxidative damage was evaluated in human hepatocytes. The results showed that WAP exhibited significant protective effects on EC-treated cells by suppressing cytotoxicity and genotoxicity, reducing reactive oxygen species (ROS) and O-2(-) formation, as well as improving mitochondrial membrane potential (MMP) and glutathione (GSH). Therefore, WAP has the potential as an important therapeutic agent or supplement for hepatic oxidative damage.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Gastroenterology & Hepatology
Macarena Pozo-Morales, Ines Garteizgogeascoa, Camille Perazzolo, Juhoon So, Donghun Shin, Sumeet Pal Singh
Summary: This study successfully observed the changes in hepatocyte calcium dynamics by taking advantage of the transparency of zebrafish larvae. The presence of calcium oscillations, waves, and spikes in vivo were demonstrated, and it was found that calcium waves are related to nutrition intake and negatively regulate starvation-induced lipid droplet accumulation.
Article
Toxicology
M. Teresa Donato, Nuria Jimenez, Maria Pelecha, Laia Tolosa
Summary: Drug-induced liver injury (DILI) is a common and serious adverse drug reaction that often leads to drug development failure and withdrawal. Enhanced levels of reactive oxygen species (ROS) have been identified as a major mechanism of DILI. Human-derived cell models, such as Upcyte human hepatocytes and HepaRG cells, are suitable for long-term hepatotoxicity assessments and mechanistic studies. These cell models maintain the expression and functionality of phase I and phase II enzymes, as well as antioxidant enzymes, making them suitable for routine toxicological assessments during drug preclinical testing.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hui Zou, Huayi Qu, Yusheng Bian, Jian Sun, Tao Wang, Yonggang Ma, Yan Yuan, Jianhong Gu, Jianchun Bian, Zongping Liu
Summary: Microplastics have emerged as a new type of environmental pollutant that can accumulate in various tissues and organs of the body, leading to chronic damage. This study investigated the impact of polystyrene microplastics (PS-MPs) with different particle sizes (5 μm and 0.5 μm) on oxidative stress in the liver using mouse models. The results demonstrated that PS-MPs exposure resulted in decreased body weight and liver-to-body weight ratio. Histological and electron microscopy analysis revealed disorganized cellular structure, nuclear crinkling, and mitochondrial vacuolation in the liver tissue exposed to PS-MPs. Moreover, PS-MPs exposure exacerbated oxidative stress in hepatocytes, with the 5 μm PS-MPs group showing more severe damage compared to the 0.5 μm PS-MPs group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Youdong Li, Yong-Jiang Xu, Chin Ping Tan, Yuanfa Liu
Summary: This study found that sinapine can protect the liver by down-regulating the expression of MCJ protein to inhibit oxidative stress. The research also confirmed that sinapine can reduce MDA levels, increase SOD and GSH-Px levels, and decrease ROS levels and mitochondrial membrane potential, further supporting its protective effects on the liver.
Article
Biochemistry & Molecular Biology
Zhijun Ning, Juan Lan, Xuanxuan Jiang, Gaolong Zhong, Hui Zhang, Fang Wan, Shaofeng Wu, Zhaoxin Tang, Rana Muhammad Bilal, Lianmei Hu, Riming Huang
Summary: Arsenic (As) has received widespread attention for its high toxic effects, but the underlying mechanism is still unclear. This study found that arsenic trioxide (ATO) has damaging effects on chicken hepatocytes, and regulating autophagy can attenuate the hepatocyte damage induced by ATO exposure.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Food Science & Technology
Jiabin Shi, Yaling Wang, Wenlin Xu, Guodong Cai, Hui Zou, Yan Yuan, Jianhong Gu, Zongping Liu, Jianchun Bian
Summary: This study investigates the molecular mechanism of liver damage induced by BEA, revealing that Nrf2 nuclear translocation plays a crucial role in BEA-induced oxidative stress and hepatotoxicity. Furthermore, the study shows a correlation between Nrf2 activation and autophagy.
Article
Biotechnology & Applied Microbiology
Acharya Balkrishna, Vivek Gohel, Priya Kumari, Moumita Manik, Kunal Bhattacharya, Rishabh Dev, Anurag Varshney
Summary: The prevalence of nonalcoholic steatohepatitis (NASH) has increased in recent years, and Livogrit, a tri-herbal Ayurvedic prescription medicine, has shown potential as a hepatoprotective agent that can prevent the development of NASH by reducing lipid accumulation, oxidative injury, inflammation, and promoting liver function.
Article
Environmental Sciences
Nan Li, Bao-Jin Yi, Muhammad Asmat Ullah Saleem, Xue-Nan Li, Jin Long Li
Summary: This study investigates the role of autophagy in cadmium-induced cytotoxicity in bird hepatocytes. Low-dose cadmium activates autophagy, reducing oxidative stress and cell death, while high-dose cadmium inhibits autophagy and promotes apoptosis. The autophagy agonist Rapamycin reduces cadmium-induced oxidative stress and cytotoxicity, while the autophagy inhibitor 3-Methyladenine has the opposite effect.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Jinglong Chen, Danping Wang, Yibo Zong, Xiaojing Yang
Summary: The research demonstrates that DHA protects hepatocytes from oxidative damage by activating mitophagy. Both in vitro and in vivo experiments have shown that DHA inhibits oxidative stress and promotes mitophagy, enhancing antioxidant capacity in liver cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Verena von Buelow, Sarah Gindner, Anne Baier, Laura Hehr, Nicola Buss, Lena Russ, Sarah Wrobel, Victoria Wirth, Kuscha Tabatabai, Thomas Quack, Simone Haeberlein, Patrik Kadesch, Stefanie Gerbig, Katja R. Wiedemann, Bernhard Spengler, Annabel Mehl, Gertrud Morlock, Gabriele Schramm, Joern Pons-Kuehnemann, Franco H. Falcone, R. Alan Wilson, Katrin Bankov, Peter Wild, Christoph G. Grevelding, Elke Roeb, Martin Roderfeld
Summary: In this study, it was demonstrated that soluble egg products of the parasite S. mansoni completely reprogram lipid and carbohydrate metabolism, causing oxidative stress-induced cell damage in the host parenchyma. The eggs take advantage of the host environment through metabolic reprogramming of hepatocytes and enterocytes, and induce DNA damage, promoting hepatocellular damage. These findings have important implications for international health efforts.
Article
Food Science & Technology
Wu-Joo Lee, Seong-Ho Lee
Summary: Oxidative stress is a major cause of tissue damage and human chronic diseases. This study found that protocatechuic acid (PCA) effectively protects hepatic cells against H2O2-induced oxidative stress and cell death.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Haitao Li, Rui Sang, Xin Zhao, Chunting Li, Wei Wang, Meng Wang, Bingjie Ge, Xuemei Zhang
Summary: In this study, it is found that taraxasterol, an active component of Taraxacum, can protect against immune-mediated liver injuries in poultry by activating the Nrf2/Keap1 signaling pathway and regulating cell autophagy and apoptosis in AFB1-induced hepatocytes.
Article
Biochemistry & Molecular Biology
Estela Villanueva-Badenas, M. Teresa Donato, Laia Tolosa
Summary: Hepatotoxicity or drug-induced liver injury (DILI) is a significant problem in drug development, leading to drug failure and regulatory measures. The development of a co-culture system involving hepatocytes and other cell types has been shown to enhance the understanding and prediction of iDILI. In this study, a co-culture system using HepG2 cells and THP-1-derived macrophages was established and used to evaluate the effects of model iDILI compounds on viability and oxidative stress induction.
Article
Cell Biology
Emmanuel Lujan, Liliana N. Guerra, Alejandro Soba, Nicolas Visacovsky, Daniel Gandia, Juan C. Calvo, Cecilia Suarez
INTEGRATIVE BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Daniela Soto, Maria Gomez-Serrano, Azul Pieralisi, Juan C. Calvo, Belen Peral, Liliana N. Guerra
Article
Biochemistry & Molecular Biology
A. Pieralisi, C. Martini, D. Soto, M. C. Vila, J. C. Calvo, L. N. Guerra
Article
Cell Biology
Emmanuel Lujan, Daniela Soto, Maria S. Rosito, Alejandro Soba, Liliana N. Guerra, Juan C. Calvo, Guillermo Marshall, Cecilia Suarez
INTEGRATIVE BIOLOGY
(2018)
Article
Oncology
L. N. Guerra, C. Suarez, D. Soto, A. Schiappacasse, D. Sapochnik, P. Sacca, G. Piwien-Pilipuk, B. Peral, J. C. Calvo
CLINICAL & TRANSLATIONAL ONCOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Pablo Calzadilla, Daiana Sapochnik, Soledad Cosentino, Virginia Diz, Lelia Dicelio, Juan Carlos Calvo, Liliana N. Guerra
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2011)
Article
Biochemistry & Molecular Biology
P. Calzadilla, M. Gomez-Serrano, E. Garcia-Santos, A. Schiappacasse, Y. Abalde, J. C. Calvo, B. Peral, L. N. Guerra
Article
Pharmacology & Pharmacy
Evelyn Frontera, Martin F. Desimone, Mauricio C. De Marzi, Liliana N. Guerra
Summary: The study aimed to increase the cellular uptake of NAC by encapsulating it in silica nanoparticles, but the coated nanoparticles showed a reduced effect on Tg cellular accumulation.
THERAPEUTIC DELIVERY
(2021)
Article
Biology
Vanina L. Julianelli, Liliana N. Guerra, Juan C. Calvo
Article
Medical Laboratory Technology
L. N. Guerra, E. A. Miler, S. Moiguer, M. Karner, A. M. Orlandi, H. Fideleff, J. A. Burdman
CLINICA CHIMICA ACTA
(2006)
Article
Medical Laboratory Technology
LN Guerra, MDCR de Molina, EA Miler, S Moiguer, M Karner, JA Burdman
CLINICA CHIMICA ACTA
(2005)
Article
Clinical Neurology
JA Burdman, LN Guerra, MT Calabrese, A Basso
NEUROLOGICAL RESEARCH
(2001)
Article
Biochemistry & Molecular Biology
LN Guerra, S Moiguer, M Karner, MDR de Molina, CM Sreider, JA Burdman
Correction
Medical Laboratory Technology
L. N. Guerra, E. A. Miler, S. Moiguer, M. Karner, A. M. Orlandi, H. Fideleff, J. A. Burdman
CLINICA CHIMICA ACTA
(2007)