4.7 Article

Facile fabrication of novel konjac glucomannan films with antibacterial properties via microfluidic spinning strategy

Journal

CARBOHYDRATE POLYMERS
Volume 208, Issue -, Pages 469-476

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.12.102

Keywords

Microfluidic spinning technology; Konjac glucomannan; Films; Antibacterial properties; Wound healing

Funding

  1. National Natural Science Foundation of China [31772045, 31471704, 21736006, 21474052]
  2. Scientific Research Foundation of Graduate School of Fujian Agriculture and Forestry University [324-1122yb034]

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The exploration of methods to produce biomaterials with antibacterial properties in ultra-small scales is of great scientific and technological interest. Here, we reported a microfluidic spinning approach to prepare a novel film combined with konjac glucomannan (KGM), polyvinylpyrrolidone (PVP), and epigallocatechin gallate (EGCG). The film was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis. This film was transparent, orderly, thermally stable, and uniform in size, with an average width less than 1 mu m. Also, the film exhibited excellent antibacterial efficiency (97.1% against E. coli, 99.7% against S. aureus, 97.3% against S. enterica and 99.9% against B. subtilis) in our antibacterial test. In addition, the film promoted wound healing with the advanced development of neovascularization and hair follicles. This strategy provides a facile and green pathway for the construction of biomaterial films for medical applications.

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