Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

(2011) D. Meynard et al.   BLOOD

 -thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism

(2011) Y. Ginzburg et al.   BLOOD

Hepcidin and iron regulation, 10 years later

(2011) T. Ganz   BLOOD

Reduced Expression of Ferroportin-1 Mediates Hyporesponsiveness of Suckling Rats to Stimuli That Reduce Iron Absorption

(2011) Deepak Darshan et al.   GASTROENTEROLOGY

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

(2011) Elena Corradini et al.   HEPATOLOGY

Hepcidin in β-thalassemia

(2010) Elizabeta Nemeth   Annals of the New York Academy of Sciences

Iron-Sensing Proteins that Regulate Hepcidin and Enteric Iron Absorption

(2010) Mitchell D. Knutson   Annual Review of Nutrition

Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-  and Tfr2-  isoforms in different tissues

(2010) A. Roetto et al.   BLOOD

Severe iron deficiency blunts the response of the iron regulatory gene Hamp and pro-inflammatory cytokines to lipopolysaccharide

(2010) D. Darshan et al.   HAEMATOLOGICA

Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation

(2010) M. Poli et al.   HAEMATOLOGICA

Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli

(2009) H. Huang et al.   BLOOD

BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression

(2009) L. Kautz et al.   BLOOD

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

(2009) T. Tanno et al.   BLOOD

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

(2009) K. Mleczko-Sanecka et al.   BLOOD

Bone Morphogenetic Protein Signaling Is Impaired in an Hfe Knockout Mouse Model of Hemochromatosis

(2009) Elena Corradini et al.   GASTROENTEROLOGY

Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes

(2009) G. Ramey et al.   HAEMATOLOGICA

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload

(2009) Daniel F. Wallace et al.   HEPATOLOGY

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo

(2009) S. Soe-Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

(2008) Y. Xia et al.   BLOOD

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

(2007) L. Silvestri et al.   BLOOD