Dissecting metabolism using zebrafish models of disease

Notch signaling regulates the expression of glycolysis-related genes in a context-dependent manner during embryonic development

(2018) Shuhei Kuwabara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolomics and Isotope Tracing

(2018) Cholsoon Jang et al.   CELL

New Developments in CRISPR/Cas-based Functional Genomics and their Implications for Research Using Zebrafish

(2018) Sergey V. Prykhozhij et al.   CURRENT GENE THERAPY

A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish

(2018) Roland S. Wu et al.   DEVELOPMENTAL CELL

Deep phenotyping in zebrafish reveals genetic and diet-induced adiposity changes that may inform disease risk

(2018) James E.N. Minchin et al.   JOURNAL OF LIPID RESEARCH

Animal models of obesity and diabetes mellitus

(2018) Maximilian Kleinert et al.   Nature Reviews Endocrinology

Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins

(2018) Maomao Zhang et al.   Cancer Discovery

Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model

(2018) Vadim Grigura et al.   Biology Open

Canonical Wnt signaling remodels lipid metabolism in zebrafish hepatocytes following Ras oncogenic insult

(2018) Yuxiao Yao et al.   CANCER RESEARCH

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth

(2018) Andrew G Cox et al.   EMBO JOURNAL

m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition

(2017) Boxuan Simen Zhao et al.   NATURE

m6A modulates haematopoietic stem and progenitor cell specification

(2017) Chunxia Zhang et al.   NATURE

Little Fish, Big Data: Zebrafish as a Model for Cardiovascular and Metabolic Disease

(2017) Philipp Gut et al.   PHYSIOLOGICAL REVIEWS

Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25(OH) 2 D 3

(2017) Xuyan Peng et al.   Cell Reports

MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect

(2017) Nataly Shtraizent et al.   eLife

A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)

(2017) Imelda T Sandoval et al.   eLife

The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis

(2017) Karen Mendelson et al.   eLife

Obesity

(2017) Pedro González-Muniesa et al.   Nature Reviews Disease Primers

ATF4 overexpression induces early onset of hyperlipidaemia and hepatic steatosis and enhances adipogenesis in zebrafish

(2017) Kun-Yun Yeh et al.   Scientific Reports

A Next Generation Multiscale View of Inborn Errors of Metabolism

(2016) Carmen A. Argmann et al.   Cell Metabolism

Cannabinoid receptor signaling regulates liver development and metabolism

(2016) Leah Y. Liu et al.   DEVELOPMENT

A genetic screen for zebrafish mutants with hepatic steatosis identifies a locus required for larval growth

(2016) Sarah E. Hugo et al.   JOURNAL OF ANATOMY

Lipid dynamics in zebrafish embryonic development observed by DESI-MS imaging and nanoelectrospray-MS

(2016) V. Pirro et al.   Molecular BioSystems

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

(2016) Justin L. Tan et al.   MOLECULAR CELL

Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

(2016) Andrew G. Cox et al.   NATURE CELL BIOLOGY

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis

(2016) Andrew G. Cox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

(2016) C. K. Kaufman et al.   SCIENCE

Hypoxia as a therapy for mitochondrial disease

(2016) I. H. Jain et al.   SCIENCE

Zebrafish Embryonic Lipidomic Analysis Reveals that the Yolk Cell Is Metabolically Active in Processing Lipid

(2016) Daniel Fraher et al.   Cell Reports

Prostaglandin signaling regulates nephron segment patterning of renal progenitors during zebrafish kidney development

(2016) Shahram Jevin Poureetezadi et al.   eLife

Metabolomic Characterizations of Liver Injury Caused by Acute Arsenic Toxicity in Zebrafish

(2016) Caixia Li et al.   PLoS One

The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration

(2015) Andrew G Cox et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish

(2015) Julien Ablain et al.   DEVELOPMENTAL CELL

Zebrafish: An Important Tool for Liver Disease Research

(2015) Wolfram Goessling et al.   GASTROENTEROLOGY

Zebrafish lacking functional DNA polymerase gamma survive to juvenile stage, despite rapid and sustained mitochondrial DNA depletion, altered energetics and growth

(2015) Jennifer J. Rahn et al.   NUCLEIC ACIDS RESEARCH

Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes

(2015) Zhen Li et al.   PLoS One

Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue

(2015) James E. N. Minchin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Post-Developmental Genetic Screen for Zebrafish Models of Inherited Liver Disease

(2015) Seok-Hyung Kim et al.   PLoS One

S1P-Yap1 Signaling Regulates Endoderm Formation Required for Cardiac Precursor Cell Migration in Zebrafish

(2014) Hajime Fukui et al.   DEVELOPMENTAL CELL

Prostaglandin E2 Regulates Liver versus Pancreas Cell-Fate Decisions and Endodermal Outgrowth

(2014) Sahar Nissim et al.   DEVELOPMENTAL CELL

carbamoyl-phosphate synthetase 2,aspartate transcarbamylase, anddihydroorotase(cad) regulates Notch signaling and vascular development in zebrafish

(2014) Baptiste Coxam et al.   DEVELOPMENTAL DYNAMICS

Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish

(2014) A. M. Vacaru et al.   Disease Models & Mechanisms

Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition

(2014) Valerie Sapp et al.   HEPATOLOGY

GLUT2-Mediated Glucose Uptake and Availability Are Required for Embryonic Brain Development in Zebrafish

(2014) Rubén Marín-Juez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Modelling inborn errors of metabolism in zebrafish

(2014) Kim Wager et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish

(2014) Deanna L. Howarth et al.   PLoS Genetics

Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo

(2013) J. M. Harris et al.   BLOOD

Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis

(2013) Vera Mugoni et al.   CELL

Long-Chain Acyl-CoA Synthetase 4A Regulates Smad Activity and Dorsoventral Patterning in the Zebrafish Embryo

(2013) Rosa Linda Miyares et al.   DEVELOPMENTAL CELL

Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease

(2013) O. Tsedensodnom et al.   Disease Models & Mechanisms

The emerging use of zebrafish to model metabolic disease

(2013) A. Seth et al.   Disease Models & Mechanisms

Dwarfism and Increased Adiposity in thegh1Mutant Zebrafishvizzini

(2013) Sarah K. McMenamin et al.   ENDOCRINOLOGY

Homeostatic generation of reactive oxygen species protects the zebrafish liver from steatosis

(2013) Justin M. Nussbaum et al.   HEPATOLOGY

The Development of Highly Potent Inhibitors for Porcupine

(2013) Xiaolei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system

(2013) Li-En Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cannabinoid receptor 1 promotes hepatic lipid accumulation and lipotoxicity through the induction of SREBP-1c expression in zebrafish

(2013) Wan-Yu Pai et al.   TRANSGENIC RESEARCH

Zebrafish as a model system for mitochondrial biology and diseases

(2013) Shelby L. Steele et al.   Translational Research

The zebrafish as a model for complex tissue regeneration

(2013) Matthew Gemberling et al.   TRENDS IN GENETICS

transparent, a gene affecting stripe formation in Zebrafish, encodes the mitochondrial protein Mpv17 that is required for iridophore survival

(2013) J. Krauss et al.   Biology Open

Studying non-alcoholic fatty liver disease with zebrafish: a confluence of optics, genetics, and physiology

(2012) Amnon Schlegel   CELLULAR AND MOLECULAR LIFE SCIENCES

S1P1 inhibits sprouting angiogenesis during vascular development

(2012) A. B. Shoham et al.   DEVELOPMENT

The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2

(2012) Konstantin Gaengel et al.   DEVELOPMENTAL CELL

A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting

(2012) S. E. Hugo et al.   GENES & DEVELOPMENT

Hooked! Modeling human disease in zebrafish

(2012) Cristina Santoriello et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting protein lipidation in disease

(2012) Marilyn D. Resh   TRENDS IN MOLECULAR MEDICINE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish

(2011) Prakash C. Thakur et al.   HEPATOLOGY

Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish

(2011) Ayca Cinaroglu et al.   HEPATOLOGY

DHODH modulates transcriptional elongation in the neural crest and melanoma

(2011) Richard Mark White et al.   NATURE

Zebrafish: gaining popularity in lipid research

(2010) Maarit Hölttä-Vuori et al.   BIOCHEMICAL JOURNAL

White adipose tissue development in zebrafish is regulated by both developmental time and fish size

(2010) Dru Imrie et al.   DEVELOPMENTAL DYNAMICS

Akt2 Modulates Glucose Availability and Downstream Apoptotic Pathways during Development

(2010) Penny J. Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-adenosylhomocysteine hydrolase deficiency: two siblings with fetal hydrops and fatal outcomes

(2010) Randall Grubbs et al.   JOURNAL OF INHERITED METABOLIC DISEASE

On the diabetic menu: Zebrafish as a model for pancreas development and function

(2009) Mary D. Kinkel et al.   BIOESSAYS

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL

A new model system swims into focus: using the zebrafish to visualize intestinal lipid metabolismin vivo

(2009) Juliana D Carten et al.   Clinical Lipidology

Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development

(2009) A. Ng et al.   DEVELOPMENT

TNF -dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase

(2009) R. P. Matthews et al.   DEVELOPMENT

Ontogeny and nutritional control of adipogenesis in zebrafish (Danio rerio)

(2009) Edward J. Flynn et al.   JOURNAL OF LIPID RESEARCH

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation

(2008) Michael J. Passeri et al.   HEPATOLOGY

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE