Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish

Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease

(2013) O. Tsedensodnom et al.   Disease Models & Mechanisms

Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development

(2013) L. Y. Liu et al.   Disease Models & Mechanisms

Defining Hepatic Dysfunction Parameters in Two Models of Fatty Liver Disease in Zebrafish Larvae

(2013) Deanna L. Howarth et al.   Zebrafish

The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: Analysis of stellate cell entry into the developing liver

(2012) Chunyue Yin et al.   HEPATOLOGY

Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice

(2012) Cheng Zhang et al.   TOXICOLOGY LETTERS

Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model

(2012) Jin-Sook Lee et al.   TOXICOLOGY LETTERS

Alcohol Disrupts Endoplasmic Reticulum Function and Protein Secretion in Hepatocytes

(2011) Deanna L. Howarth et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans

(2011) Changting Xiao et al.   DIABETES

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

(2011) Kezhong Zhang et al.   EMBO JOURNAL

Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis

(2011) Mary E. Rinella et al.   HEPATOLOGY

Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish

(2011) Ayca Cinaroglu et al.   HEPATOLOGY

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress

(2011) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism

(2011) Sri Devi Narasimhan et al.   PLoS Genetics

CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophaghy in HepG2 E47 cells

(2010) Defeng Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes

(2010) Laurent Magne et al.   JOURNAL OF HEPATOLOGY

Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress

(2010) Keisuke Yamamoto et al.   MOLECULAR BIOLOGY OF THE CELL

PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury

(2010) T. E. North et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia–reperfusion

(2010) I Ben Mosbah et al.   Cell Death & Disease

Alcoholic Liver Disease

(2009) Robert S O’Shea et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance

(2009) R. Ye et al.   DIABETES

Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats

(2009) Masao Shinohara et al.   HEPATOLOGY

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation

(2008) Michael J. Passeri et al.   HEPATOLOGY

Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease

(2008) Nobito Higuchi et al.   HEPATOLOGY RESEARCH

Glyceroneogenesis Is the Dominant Pathway for Triglyceride Glycerol Synthesisin Vivoin the Rat

(2008) Colleen K. Nye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination of Growth and Endoplasmic Reticulum Stress Signaling by Regulator of Calcineurin 1 (RCAN1), a Novel ATF6-inducible Gene

(2008) Peter J. Belmont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY