Article
Oncology
Xiangjun Liu, Mengmiao Pei, Yongbo Yu, Xiaolin Wang, Jingang Gui
Summary: The tumor metastasis in high-risk neuroblastoma patients is a significant problem that affects patient survival. This study utilized comprehensive bioinformatics analysis to identify LPAR1 as a potential target for the treatment of neuroblastoma. The decreased expression of LPAR1 in neuroblastoma cells and the migration-inhibitory effects of LPA-LPAR1 axis suggest that LPAR1 may be a promising target for future neuroblastoma treatment.
Article
Biochemistry & Molecular Biology
Da-Yong Wang, Jing Zhang, Hai-Xia Li, Yan-Xia Zhang, Mi-Rong Jing, Chun-Bo Cai, Di Wang, Hui-Wen Qi, Yi-Zhen Wang, Hao-Jie Chen, Tao Li, Yuan-Kun Zhai, Xin-Ying Ji, Dong-Dong Wu
Summary: Inhibition of endogenous H2S generation can significantly suppress the growth of nasopharyngeal carcinoma (NPC), making it a potential novel therapeutic target for human NPC cells.
MOLECULAR CARCINOGENESIS
(2023)
Article
Gastroenterology & Hepatology
Haixiao Wang, Guangli Sun, Penghui Xu, Jialun Lv, Xing Zhang, Lu Zhang, Sen Wang, Jiacheng Cao, Yiwen Xia, Zhe Xuan, Bowen Li, Xiaoxu Huang, Tianlu Jiang, Lang Fang, Zekuan Xu
Summary: Our study revealed that circTMEM87A is upregulated in GC tissues and cell lines, and its high expression is associated with poor prognosis in GC patients. CircTMEM87A functions as an oncogene by sponging miR-142-5p to regulate ULK1 expression and promote GC progression, indicating its potential as a prognostic biomarker and therapeutic target in GC.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Pugui Li, Kun Zhang, Shijie Tang, Weizhu Tang
Summary: This study found that LncRNA HAGLROS is highly expressed in nephroblastoma cells and plays a promoting role in tumor progression. Silencing HAGLROS can inhibit cell proliferation, migration, and invasion, and promote cell apoptosis. In addition, inhibiting autophagy can reverse the effects caused by HAGLROS silencing in nephroblastoma cells.
Article
Plant Sciences
Ha-Na Oh, Ah-Won Kwak, Mee-Hyun Lee, Eunae Kim, Goo Yoon, Seung-Sik Cho, Kangdong Liu, Jung-Il Chae, Jung-Hyun Shim
Summary: The study investigated the mechanism of PPT-induced apoptosis in NSCLC cells, revealing that the inhibition of c-MET kinase activity played a crucial role in PPT-induced cell death.
Article
Multidisciplinary Sciences
Laura Bownes, Adele P. Williams, Raoud Marayati, Laura L. Stafman, Hooper Markert, Colin H. Quinn, Nikita Wadhwani, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Elizabeth Mroczek-Musulman, Elizabeth A. Beierle
Summary: The EZH2 inhibitor GSK343 has significant effects on the treatment of neuroblastoma, significantly reducing cell viability, migration, and stemness, while inhibiting tumor growth. This suggests that further research into the anti-tumor mechanisms of EZH2 inhibitors in neuroblastoma cells is warranted.
Article
Biochemistry & Molecular Biology
Chaima Cherif, Dang Tan Nguyen, Clement Paris, Thi Khanh Le, Thibaud Sefiane, Nadine Carbuccia, Pascal Finetti, Max Chaffanet, Abdessamad El Kaoutari, Julien Vernerey, Ladan Fazli, Martin Gleave, Mohamed Manai, Philippe Barthelemy, Daniel Birnbaum, Francois Bertucci, David Taieb, Palma Rocchi
Summary: Menin (MEN1) protein is highly regulated by HSP27, overexpressed in high-grade PC and CRPC, and high MEN1 mRNA expression is associated with decreased biochemical relapse-free and overall survival. Silencing Menin helps inhibit CRPC cell proliferation, tumor growth, and restore chemotherapeutic sensitivity.
Article
Cell Biology
Vinicius Toledo Ribas, Bjorn Friedhelm Vahsen, Lars Tatenhorst, Veronica Estrada, Vivian Dambeck, Raquel Alves Almeida, Mathias Baehr, Uwe Michel, Jan Christoph Koch, Hans Werner Mueller, Paul Lingor
Summary: Inhibition of ULK1 promotes axonal regeneration and neurite outgrowth, increases neuronal survival, and enhances axonal protection after optic nerve and spinal cord injuries. Additionally, it leads to increased sprouting of serotonergic and dopaminergic axons after spinal cord injury by activating ERK1 and reducing RhoA and ROCK2 expression. ULK1 is identified as a key regulator for axonal degeneration and regeneration, and a promising target for neuroprotection and regeneration in the CNS.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Yuyi Wang, Ombretta Salvucci, Hidetaka Ohnuki, Andy D. Tran, Taekyu Ha, Jing-Xin Feng, Michael DiPrima, Hyeongil Kwak, Dunrui Wang, Yanlin Yu, Michael Kruhlak, Giovanna Tosato
Summary: SHP2 is essential for promoting endothelial cell survival and growth in tumor vasculature remodeling. Inhibiting SHP2 activity leads to reduced tumor growth and degeneration of tumor vasculature. Combination of SHP2 inhibitors with Ang2/TIE2 inhibitors shows promise in effectively targeting the tumor endothelium.
EMBO MOLECULAR MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Caitlin B. Conboy, Jennifer A. Yonkus, Eee L. N. H. Buckarma, Dong-Gi Mun, Nathan W. Werneburg, Ryan D. Watkins, Roberto Alva-Ruiz, Jennifer L. Tomlinson, Yi Guo, Juan Wang, Daniel O'Brien, Chantal E. McCabe, Erik Jessen, Rondell P. Graham, Rogier C. Buijsman, Diep Vu, Jos de Man, Sumera I. Ilyas, Mark J. Truty, Mitesh Borad, Akhilesh Pandey, Gregory J. Gores, Rory L. Smoot
Summary: A novel LCK inhibitor, NTRC 0652-0, was found to inhibit YAP signaling in CCA cells. It decreased tyrosine phosphorylation, nuclear localization, and co-transcriptional activity of YAP, leading to apoptotic cell death in CCA cell lines. FGFR2 fusion-positive CCA was identified as a susceptible subset, and NTRC 0652-0 showed preclinical efficacy in patient-derived organoid and xenograft models.
JOURNAL OF HEPATOLOGY
(2023)
Article
Cell Biology
Chenglong Chen, Hongliang Zhang, Yiyang Yu, Qingshan Huang, Wei Wang, Jianfang Niu, Jingbing Lou, Tingting Ren, Yi Huang, Wei Guo
Summary: The study found that chloroquine induces apoptosis in osteosarcoma cells and inhibits their proliferation, migration, invasion, and lamellipodia formation in vitro. In vivo experiments demonstrated that chloroquine inhibits tumor growth and lung metastasis. Lung metastasis in osteosarcoma patients was associated with p-STAT3 expression.
Article
Biochemistry & Molecular Biology
Kai Chen, Yifu Hou, Rui Liao, Youzan Li, Hongji Yang, Jun Gong
Summary: Studies have shown that lncRNA SNHG6 is upregulated in HCC, promoting cell proliferation and inhibiting the targeting of E2F1 by competitively binding miR-204-5p.
Article
Cell Biology
Chi Chi, Wenjie Hou, Yi Zhang, Jie Chen, Zongji Shen, Youguo Chen, Min Li
Summary: In this study, it was found that the long non-coding RNA PDHB-AS is down-regulated in cervical cancer cells. Overexpression of PDHB-AS can suppress malignant behaviors of cervical cancer cells. PDHB-AS functions as a tumor suppressor by inhibiting the Wnt/β-catenin pathway, and it also interacts with other molecules such as miR-4536-5p, miR-582-5p, and DKK1 to regulate cisplatin resistance and tumor growth in cervical cancer. These findings suggest the therapeutic potential of PDHB-AS as a target for cervical cancer treatment.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Sanjeev Kumar Srivastava, Mohammad Aslam Khan, Shashi Anand, Haseeb Zubair, Sachin Kumar Deshmukh, Girijesh Kumar Patel, Seema Singh, Joel Andrews, Bin Wang, James Elliot Carter, Ajay Pratap Singh
Summary: The study revealed that MYB and AR interact in prostate cancer cells, and overexpression of MYB can lead to resistance to castration and rapid growth post-castration, resulting in shorter survival of mice.
BRITISH JOURNAL OF CANCER
(2022)
Article
Cell Biology
Rong Deng, Hai-Liang Zhang, Jun-Hao Huang, Rui-Zhao Cai, Yan Wang, Yu-Hong Chen, Bing-Xin Hu, Zhi-Peng Ye, Zhi-Ling Li, Jia Mai, Yun Huang, Xuan Li, Xiao-Dan Peng, Gong-Kan Feng, Jun-Dong Li, Jun Tang, Xiao-Feng Zhu
Summary: ULK1 deficiency impairs mitophagy in breast cancer cells under hypoxia, leading to accumulation of damaged mitochondria, NLRP3 inflammasome activation, and bone metastasis. Phosphorylation of ULK1 triggers its degradation, and a negative correlation between ULK1 expression levels and p-MAPK1/3 was observed. The use of MAP2K/MEK inhibitor trametinib can restore mitophagy function and inhibit NLRP3 inflammasome activation to reduce bone metastasis.
Article
Multidisciplinary Sciences
Yoshinori Takahashi, Haiyan He, Zhenyuan Tang, Tatsuya Hattori, Ying Liu, Megan M. Young, Jacob M. Serfass, Longgui Chen, Melat Gebru, Chong Chen, Carson A. Wills, Jennifer M. Atkinson, Han Chen, Thomas Abraham, Hong-Gang Wang
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Tatsuya Hattori, Yoshinori Takahashi, Longgui Chen, Zhenyuan Tang, Carson A. Wills, Xinwen Liang, Hong-Gang Wang
Summary: Inhibition of ESCRT-III-dependent autophagosome sealing process triggers noncanonical Caspase-8 activation and apoptosis, which may open new avenues for therapeutic targeting of autophagy in cancer.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Pediatrics
Carson Wills, Katherine Mercer, Jozef Malysz, Lidys Rivera Galvis, Chandrika Gowda
Summary: This article reports a rare case of lymphadenopathy in a child, emphasizing the importance of long-term follow-up and tailoring the diagnostic work-up and management based on new signs and symptoms.
Article
Oncology
Xiaoming Liu, Carson A. Wills, Longgui Chen, Jiawen Zhang, Yuanjun Zhao, Mi Zhou, Jeffrey M. Sundstrom, Todd Schell, Vladimir S. Spiegelman, Megan M. Young, Hong-Gang Wang
Summary: This study investigated the role of neuroblastoma-derived small extracellular vesicles (sEVs) in promoting resistance to anti-GD2 monoclonal antibody therapy and the potential of tipifarnib in sensitizing tumors to the antibody treatment. The results showed that sEVs attenuated the efficacy of the antibody and modulated the tumor microenvironment and immune cell infiltration. Additionally, tipifarnib enhanced the antibody's effectiveness against tumor growth and prevented the immunosuppressive effects of sEVs.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Carson A. Wills, Xiaoming Liu, Longgui Chen, Yuanjun Zhao, Christopher M. Dower, Jeffrey Sundstrom, Hong-Gang Wang
Summary: This research uncovers a novel mechanism of chemotherapy-mediated metastasis, in which chemotherapeutic drugs promote breast cancer metastasis by enhancing tumor-derived small extracellular vesicles secretion. Targeted inhibition of these tumor-derived vesicles may be a promising therapeutic strategy to improve the efficacy of chemotherapy treatment.
Letter
Multidisciplinary Sciences
Jennifer Sills