Antibody specificity and promiscuity

Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries

(2018) Ryan L. Kelly et al.   JOURNAL OF MOLECULAR BIOLOGY

Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity

(2018) Julie Prigent et al.   Cell Reports

The HIV-1 envelope glycoprotein structure: nailing down a moving target

(2017) Andrew B Ward et al.   IMMUNOLOGICAL REVIEWS

NMR Detection of Semi-Specific Antibody Interactions in Serum Environments

(2017) Saeko Yanaka et al.   MOLECULES

Natural polyreactive IgA antibodies coat the intestinal microbiota

(2017) Jeffrey J. Bunker et al.   SCIENCE

Shape complementarity and hydrogen bond preferences in protein–protein interfaces: implications for antibody modeling and protein–protein docking

(2016) Daisuke Kuroda et al.   BIOINFORMATICS

Structural basis of potent Zika–dengue virus antibody cross-neutralization

(2016) Giovanna Barba-Spaeth et al.   NATURE

Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces

(2016) Cristiano De Michele et al.   PLoS Computational Biology

Antibodies Can Exploit Molecular Crowding to Bind New Antigens at Noncanonical Paratope Positions

(2016) Sharad Vashisht et al.   ChemistrySelect

Novel GM1 ganglioside-like peptide mimics prevent the association of cholera toxin to human intestinal epithelial cells in vitro

(2015) Robert K Yu et al.   GLYCOBIOLOGY

Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody

(2015) Irena Horwacik et al.   MOLECULAR & CELLULAR PROTEOMICS

Reproducibility crisis: Blame it on the antibodies

(2015) Monya Baker   NATURE

Recognition determinants of broadly neutralizing human antibodies against dengue viruses

(2015) Alexander Rouvinski et al.   NATURE

Adjustable Locks and Flexible Keys: Plasticity of Epitope-Paratope Interactions in Germline Antibodies

(2014) T. Khan et al.   JOURNAL OF IMMUNOLOGY

Specificity, polyspecificity, and heterospecificity of antibody-antigen recognition

(2014) Marc H. V. Van Regenmortel   JOURNAL OF MOLECULAR RECOGNITION

Origins of specificity and affinity in antibody–protein interactions

(2014) Hung-Pin Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamic stability contributes to immunoglobulin specificity

(2014) Jordan D. Dimitrov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Receptor mimicry by antibody F045–092 facilitates universal binding to the H3 subtype of influenza virus

(2014) Peter S. Lee et al.   Nature Communications

Carbohydrate-Mimetic Peptides for Pan Anti-Tumor Responses

(2014) Thomas Kieber-Emmons et al.   Frontiers in Immunology

Pathogens Use Structural Mimicry of Native Host Ligands as a Mechanism for Host Receptor Engagement

(2013) Nir Drayman et al.   Cell Host & Microbe

Antibody Polyreactivity in Health and Disease: Statu Variabilis

(2013) J. D. Dimitrov et al.   JOURNAL OF IMMUNOLOGY

Antibody Therapeutics in Cancer

(2013) M. X. Sliwkowski et al.   SCIENCE

Antigen–antibody interface properties: Composition, residue interactions, and features of 53 non-redundant structures

(2012) Thiruvarangan Ramaraj et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Human poly- and cross-reactive anti-viral antibodies and their impact on protection and pathology

(2012) Lucile Warter et al.   IMMUNOLOGIC RESEARCH

Limited conformational flexibility in the paratope may be responsible for degenerate specificity of HIV epitope recognition

(2012) Arijit Bhowmick et al.   INTERNATIONAL IMMUNOLOGY

Natural IgM in Immune Equilibrium and Harnessing Their Therapeutic Potential

(2012) S. V. Kaveri et al.   JOURNAL OF IMMUNOLOGY

Antigen-Driven Induction of Polyreactive IgM during Intracellular Bacterial Infection

(2012) D. D. Jones et al.   JOURNAL OF IMMUNOLOGY

Differential Reactivity of Germ Line Allelic Variants of a Broadly Neutralizing HIV-1 Antibody to a gp41 Fusion Intermediate Conformation

(2011) S. M. Alam et al.   JOURNAL OF VIROLOGY

Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood

(2011) Martin Lundberg et al.   NUCLEIC ACIDS RESEARCH

“Rational Vaccine Design” for HIV Should Take into Account the Adaptive Potential of Polyreactive Antibodies

(2011) Jordan D. Dimitrov et al.   PLoS Pathogens

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Autoimmune response and target autoantigens in Sjogren’s syndrome

(2010) John G. Routsias et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Pentapeptide commonality betweenCorynebacterium diphtheriaetoxin and theHomo sapiensproteome

(2010) Simona Lucia Bavaro et al.   Immunotherapy

Hub Promiscuity in Protein-Protein Interaction Networks

(2010) Ashwini Patil et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Guillain-Barré Syndrome Animal Model: The First Proof of Molecular Mimicry in Human Autoimmune Disorder

(2010) Nortina Shahrizaila et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

(2010) Hugo Mouquet et al.   NATURE

Glycan gimmickry by parasitic helminths: A strategy for modulating the host immune response?

(2009) I. van Die et al.   GLYCOBIOLOGY

Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site

(2009) J. Bostrom et al.   SCIENCE

The Intrinsic Contributions of Tyrosine, Serine, Glycine and Arginine to the Affinity and Specificity of Antibodies

(2008) Sara Birtalan et al.   JOURNAL OF MOLECULAR BIOLOGY

Massive peptide sharing between viral and human proteomes

(2008) Darja Kanduc et al.   PEPTIDES

Vaccination and antigenic drift in influenza

(2008) Maciej F. Boni   VACCINE

The specificity of cross-reactivity: Promiscuous antibody binding involves specific hydrogen bonds rather than nonspecific hydrophobic stickiness

(2003) Leo C. James et al.   PROTEIN SCIENCE