Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay

A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment

(2018) Gamze Ates et al.   ARCHIVES OF TOXICOLOGY

Assessment of the predictive capacity of the optimized in vitro comet assay using HepG2 cells

(2018) Yoon-hee Hong et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells

(2018) Xiaoqing Guo et al.   TOXICOLOGICAL SCIENCES

Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury

(2018) Jieyu Xu et al.   TOXICOLOGY IN VITRO

Next generation high throughput DNA damage detection platform for genotoxic compound screening

(2018) Peter Sykora et al.   Scientific Reports

Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells

(2018) Volodymyr Tryndyak et al.   FOOD AND CHEMICAL TOXICOLOGY

Quantitative differentiation of whole smoke solution-induced mutagenicity in the mouse lymphoma assay

(2017) Xiaoqing Guo et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

(2016) Steven M. Bryce et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data

(2016) Salomon Sand et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cell sources for in vitro human liver cell culture models

(2016) Katrin Zeilinger et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Empirical analysis of BMD metrics in genetic toxicology part II:in vivopotency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment

(2016) John W. Wills et al.   MUTAGENESIS

Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests

(2016) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Cadmium Chloride Induces DNA Damage and Apoptosis of Human Liver Carcinoma Cells via Oxidative Stress

(2016) Anthony Skipper et al.   International Journal of Environmental Research and Public Health

Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay

(2015) Xiaoqing Guo et al.   MUTAGENESIS

IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure–response relationships and points of departure (PoDs)

(2015) James T. MacGregor et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1and Benzo[a]pyrene in Human HepaRG Cells

(2015) April K. Marrone et al.   TOXICOLOGICAL SCIENCES

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

(2015) Rowena L. C. Sison-Young et al.   TOXICOLOGICAL SCIENCES

Micropatterned comet assay enables high throughput and sensitive DNA damage quantification

(2014) J. Ge et al.   MUTAGENESIS

Performance of Comet and Micronucleus Assays in Metabolic Competent HepaRG Cells to Predict In Vivo Genotoxicity

(2014) Ludovic Le Hégarat et al.   TOXICOLOGICAL SCIENCES

Validation of high-throughput genotoxicity assay screening using γH2AX in-cell western assay on HepG2 cells

(2013) Laure Khoury et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Quantitative approaches for assessing dose-response relationships in genetic toxicology studies

(2012) B.B. Gollapudi et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

An adaptation of the human HepaRG cells to the in vitro micronucleus assay

(2011) R. Josse et al.   MUTAGENESIS

Mechanisms in cadmium-induced carcinogenicity: recent insights

(2010) Andrea Hartwig   BIOMETALS

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays

(2010) L. Le Hegarat et al.   MUTAGENESIS

Single cell trapping and DNA damage analysis using microwell arrays

(2010) D. K. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification

(2010) Danyel G. J. Jennen et al.   TOXICOLOGICAL SCIENCES

Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells

(2009) S. Antherieu et al.   DRUG METABOLISM AND DISPOSITION

Increase the cisplatin cytotoxicity and cisplatin-induced DNA damage in HepG2 cells by XRCC1 abrogation related mechanisms

(2009) Rong Zhang et al.   TOXICOLOGY LETTERS

Metabolites in safety testing

(2009) Timothy W Robison et al.   Bioanalysis

Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: A follow-up to an ECVAM workshop

(2008) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS