DSM265 at 400 Milligrams Clears Asexual Stage Parasites but Not Mature Gametocytes from the Blood of Healthy Subjects Experimentally Infected with Plasmodium falciparum

A controlled human malaria infection model enabling evaluation of transmission-blocking interventions

(2018) Katharine A. Collins et al.   JOURNAL OF CLINICAL INVESTIGATION

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

(2018) Alejandro Llanos-Cuentas et al.   LANCET INFECTIOUS DISEASES

A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance

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A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation

(2017) Sean C Murphy et al.   JOURNAL OF INFECTIOUS DISEASES

Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study

(2017) James S McCarthy et al.   LANCET INFECTIOUS DISEASES

DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection

(2017) Mihály Sulyok et al.   LANCET INFECTIOUS DISEASES

New developments in anti-malarial target candidate and product profiles

(2017) Jeremy N. Burrows et al.   MALARIA JOURNAL

Malaria

(2017) Margaret A. Phillips et al.   Nature Reviews Disease Primers

A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study

(2016) James S. McCarthy et al.   MALARIA JOURNAL

Biology of Malaria Transmission

(2016) Elamaran Meibalan et al.   Cold Spring Harbor Perspectives in Medicine

Changes in Serological Immunology Measures in UK and Kenyan Adults Post-controlled Human Malaria Infection

(2016) Susanne H. Hodgson et al.   Frontiers in Microbiology

Evaluating the Pharmacodynamic Effect of Antimalarial Drugs in Clinical Trials by Quantitative PCR

(2015) Louise Marquart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Experimental study of the relationship between Plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of malaria transmission-reducing interventions

(2015) Dari F. Da et al.   EXPERIMENTAL PARASITOLOGY

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

(2015) Margaret A. Phillips et al.   Science Translational Medicine

Inferring Developmental Stage Composition from Gene Expression in Human Malaria

(2013) Regina Joice et al.   PLoS Computational Biology

Predicting mosquito infection from Plasmodium falciparum gametocyte density and estimating the reservoir of infection

(2013) Thomas S Churcher et al.   eLife

Primaquine to prevent transmission of falciparum malaria

(2012) Nicholas J White   LANCET INFECTIOUS DISEASES

Mosquito Feeding Assays to Determine the Infectiousness of Naturally Infected Plasmodium falciparum Gametocyte Carriers

(2012) Teun Bousema et al.   PLoS One

Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination

(2011) T. Bousema et al.   CLINICAL MICROBIOLOGY REVIEWS

A real-time, quantitative PCR method using hydrolysis probes for the monitoring of Plasmodium falciparum load in experimentally infected human volunteers

(2011) Rebecca J Rockett et al.   MALARIA JOURNAL

A Research Agenda to Underpin Malaria Eradication

(2011) Pedro L. Alonso et al.   PLOS MEDICINE

Malaria gametocytogenesis

(2010) David A. Baker   MOLECULAR AND BIOCHEMICAL PARASITOLOGY