A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

(2016) James S. McCarthy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy of OZ439 (artefenomel) against earlyPlasmodium falciparumblood-stage malaria infection in healthy volunteers

(2016) James S. McCarthy et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Piperaquine Monotherapy of Drug-SusceptiblePlasmodium falciparumInfection Results in Rapid Clearance of Parasitemia but Is Followed by the Appearance of Gametocytemia

(2016) Cielo J. Pasay et al.   JOURNAL OF INFECTIOUS DISEASES

Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial

(2016) Aung Pyae Phyo et al.   LANCET INFECTIOUS DISEASES

Using DTA and DTAARRAY Variables and Programming in WinNonlin ASCII Models to Streamline User-Defined Calculation and Data Analysis

(2015) Jun Shen et al.   AAPS Journal

How Robust Are Malaria Parasite Clearance Rates as Indicators of Drug Effectiveness and Resistance?

(2015) Ian M. Hastings et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluating the Pharmacodynamic Effect of Antimalarial Drugs in Clinical Trials by Quantitative PCR

(2015) Louise Marquart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Global malaria eradication and the importance of Plasmodium falciparum epidemiology in Africa

(2015) Robert W Snow   BMC Medicine

Supporting malaria elimination with 21st century antimalarial agent drug discovery

(2015) Thierry T. Diagana   DRUG DISCOVERY TODAY

Ferroquine and its derivatives: New generation of antimalarial agents

(2015) Waseem A. Wani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ferroquine: welcome to the next generation of antimalarials

(2015) Timothy NC Wells et al.   LANCET INFECTIOUS DISEASES

Ferroquine and artesunate in African adults and children with Plasmodium falciparum malaria: a phase 2, multicentre, randomised, double-blind, dose-ranging, non-inferiority study

(2015) Jana Held et al.   LANCET INFECTIOUS DISEASES

Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker

(2015) Kyaw M Tun et al.   LANCET INFECTIOUS DISEASES

Development of cultured Plasmodium falciparum blood-stage malaria cell banks for early phase in vivo clinical trial assessment of anti-malaria drugs and vaccines

(2015) Danielle I Stanisic et al.   MALARIA JOURNAL

Hit and lead criteria in drug discovery for infectious diseases of the developing world

(2015) Kei Katsuno et al.   NATURE REVIEWS DRUG DISCOVERY

Malaria medicines: a glass half full?

(2015) Timothy N. C. Wells et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacokinetic and Pharmacodynamic Considerations in Antimalarial Dose Optimization

(2013) Nicholas J. White   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Toxicity associated with repeated administration of artemether-lumefantrine in rats

(2013) Solomon E. Owumi et al.   ENVIRONMENTAL TOXICOLOGY

Designing the next generation of medicines for malaria control and eradication

(2013) Jeremy N Burrows et al.   MALARIA JOURNAL

The antimalarial ferroquine: from bench to clinic

(2013) C. Biot et al.   Parasite

Pharmacokinetics of Ferroquine, a Novel 4-Aminoquinoline, in Asymptomatic Carriers of Plasmodium falciparum Infections

(2012) Christian Supan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A real-time, quantitative PCR method using hydrolysis probes for the monitoring of Plasmodium falciparum load in experimentally infected human volunteers

(2011) Rebecca J Rockett et al.   MALARIA JOURNAL

Phase I randomized dose-ascending placebo-controlled trials of ferroquine - a candidate anti-malarial drug - in adults with asymptomatic Plasmodium falciparum infection

(2011) Ghyslain Mombo-Ngoma et al.   MALARIA JOURNAL

Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator

(2011) Jennifer A Flegg et al.   MALARIA JOURNAL

The parasite clearance curve

(2011) NJ White   MALARIA JOURNAL

A Pilot Randomised Trial of Induced Blood-Stage Plasmodium falciparum Infections in Healthy Volunteers for Testing Efficacy of New Antimalarial Drugs

(2011) James S. McCarthy et al.   PLoS One

The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study

(2010) R. C. Dart et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Countries race to contain resistance to key antimalarial

(2009) Udani Samarasekera   LANCET

Host immunity as a determinant of treatment outcome in Plasmodium falciparum malaria

(2009) Stephen J Rogerson et al.   LANCET INFECTIOUS DISEASES

Investigation of the Redox Behavior of Ferroquine, a New Antimalarial

(2008) Natascha Chavain et al.   MOLECULAR PHARMACEUTICS