The “other” mTOR complex: New insights into mTORC 2 immunobiology and their implications

Rictor Deficiency Aggravates Hepatic Ischemia/Reperfusion Injury in Mice by Suppressing Autophagy and Regulating MAPK Signaling

(2018) Dongwei Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus by Impairing Caspase-1 Cleavage of Rab39a

(2018) Andrew J. Monteith et al.   JOURNAL OF IMMUNOLOGY

mTORC1 and mTORC2 differentially promote natural killer cell development

(2018) Chao Yang et al.   eLife

The Kinase Complex mTOR Complex 2 Promotes the Follicular Migration and Functional Maturation of Differentiated Follicular Helper CD4+ T Cells During Viral Infection

(2018) Yaxing Hao et al.   Frontiers in Immunology

Loss of Rictor in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice

(2018) Vladimir R. Babaev et al.   Frontiers in Immunology

Rictor deficiency in dendritic cells exacerbates acute kidney injury

(2018) Helong Dai et al.   KIDNEY INTERNATIONAL

Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function

(2018) Fangjie Wang et al.   Nature Communications

mTORC1 and mTORC2 as regulators of cell metabolism in immunity

(2017) Monika Linke et al.   FEBS LETTERS

Localization of mTORC2 activity inside cells

(2017) Michael Ebner et al.   JOURNAL OF CELL BIOLOGY

Rapamycin attenuates BAFF-extended proliferation and survival via disruption of mTORC1/2 signaling in normal and neoplastic B-lymphoid cells

(2017) Qingyu Zeng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Rictor/mammalian target of rapamycin complex 2 promotes macrophage activation and kidney fibrosis

(2017) Jiafa Ren et al.   JOURNAL OF PATHOLOGY

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

(2017) Yuchao Gu et al.   MOLECULAR CELL

mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity

(2017) Khalid W. Kalim et al.   PLoS One

Influence of the Novel ATP-Competitive Dual mTORC1/2 Inhibitor AZD2014 on Immune Cell Populations and Heart Allograft Rejection

(2017) Daniel Fantus et al.   TRANSPLANTATION

mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages

(2017) Min-Hee Oh et al.   Cell Reports

Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin

(2017) Lu Huang et al.   PLOS BIOLOGY

Effect of mTORC1/mTORC2 inhibition on T cell function: potential role in graft-versus-host disease control

(2016) Ma Carmen Herrero-Sánchez et al.   BRITISH JOURNAL OF HAEMATOLOGY

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

(2016) Hu Zeng et al.   IMMUNITY

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Proliferating Helper T Cells Require Rictor/mTORC2 Complex to Integrate Signals from Limiting Environmental Amino Acids

(2016) Lee-Ann Van de Velde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TORC2 Structure and Function

(2016) Christl Gaubitz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner

(2016) Lianjun Zhang et al.   Cell Reports

Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration

(2016) Alba Diz-Muñoz et al.   PLOS BIOLOGY

Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses

(2016) Jialong Yang et al.   eLife

Intratumoral delivery of mTORC2-deficient dendritic cells inhibits B16 melanoma growth by promoting CD8+ effector T cell responses

(2016) Dàlia Raïch-Regué et al.   OncoImmunology

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

(2015) Katherine H. Schreiber et al.   AGING CELL

mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

(2015) Kristen N. Pollizzi et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo

(2015) Dàlia Raïch-Regué et al.   JOURNAL OF IMMUNOLOGY

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

(2015) Sharad Shrestha et al.   NATURE IMMUNOLOGY

Amino acid auxotrophy as a system of immunological control nodes

(2015) Peter J Murray   NATURE IMMUNOLOGY

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

Adenosine Triphosphate-Competitive mTOR Inhibitors: A New Class of Immunosuppressive Agents That Inhibit Allograft Rejection

(2014) B. R. Rosborough et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Everolimus Inhibits Anti-HLA I Antibody-Mediated Endothelial Cell Signaling, Migration and Proliferation More Potently Than Sirolimus

(2014) Y.-P. Jin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Mammalian Target of Rapamycin Complex 2 Regulates Invariant NKT Cell Development and Function Independent of Promyelocytic Leukemia Zinc-Finger

(2014) Nicolas Prevot et al.   JOURNAL OF IMMUNOLOGY

Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury

(2014) Jianzhong Li et al.   KIDNEY INTERNATIONAL

Rictor Is Required for Early B Cell Development in Bone Marrow

(2014) Yingchi Zhang et al.   PLoS One

Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction

(2013) B. R. Rosborough et al.   BLOOD

Requirement for Rictor in homeostasis and function of mature B lymphoid cells

(2013) K. Lee et al.   BLOOD

Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function

(2012) B. Kellersch et al.   BLOOD

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis

(2012) Doris Berchtold et al.   NATURE CELL BIOLOGY

Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

(2011) Xiaoqing Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE