Effect of mTORC1/mTORC2 inhibition on T cell function: potential role in graft-versus-host disease control

Post-transplant Lymphoproliferative Disorder: A Single-Center Experience

(2015) H. Ferreira et al.   TRANSPLANTATION PROCEEDINGS

Translation initiation complex eIF4F is a therapeutic target for dual mTOR kinase inhibitors in non-Hodgkin lymphoma

(2015) Christos Demosthenous et al.   Oncotarget

Combinatorial action of transcription factors orchestrates cell cycle-dependent expression of the ribosomal protein genes and ribosome biogenesis

(2014) Nagisa Nosrati et al.   FEBS Journal

Genetic and Pharmacologic Evidence That mTOR Targeting Outweighs mTORC1 Inhibition as an Antimyeloma Strategy

(2014) X. Chen et al.   MOLECULAR CANCER THERAPEUTICS

Effect of Inhibiting the Signal of Mammalian Target of Rapamycin on Memory T Cells

(2014) S. Chen et al.   TRANSPLANTATION PROCEEDINGS

Strategies for the management of adverse events associated with mTOR inhibitors

(2014) Bruce Kaplan et al.   Transplantation Reviews

PI3Kδ Inhibition Augments the Efficacy of Rapamycin in Suppressing Proliferation of Epstein−Barr Virus (EBV)+ B Cell Lymphomas

(2013) S. Furukawa et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase

(2013) Deborah S. Mortensen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas

(2013) B. Gini et al.   CLINICAL CANCER RESEARCH

Activation of AR Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation

(2013) Y. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Defining the Role of Sirolimus in the Management of Graft-versus-Host Disease: From Prophylaxis to Treatment

(2012) Ahmed Abouelnasr et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The combination of sirolimus plus tacrolimus improves outcome after reduced-intensity conditioning, unrelated donor hematopoietic stem cell transplantation compared with cyclosporine plus mycofenolate

(2012) J. A. Perez-Simon et al.   HAEMATOLOGICA

Mammalian Target of Rapamycin Integrates Diverse Inputs To Guide the Outcome of Antigen Recognition in T Cells

(2012) A. T. Waickman et al.   JOURNAL OF IMMUNOLOGY

Sirolimus Enhances the Magnitude and Quality of Viral-Specific CD8+ T-Cell Responses to Vaccinia Virus Vaccination in Rhesus Macaques

(2011) A. P. Turner et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells

(2011) K. W. Juchem et al.   BLOOD

Rapamycin-sensitive signals control TCR/CD28-drivenIfng,Il4andFoxp3transcription and promoter region methylation

(2011) Romana Tomasoni et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

(2011) Xiaoqing Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling

(2011) V. S. Rodrik-Outmezguine et al.   Cancer Discovery

Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD

(2010) Shoba Amarnath et al.   Autophagy

Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival

(2010) Bryan C. Barnhart et al.   CANCER BIOLOGY & THERAPY

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

Early events governing memory CD8+ T-cell differentiation

(2010) J. J. Obar et al.   INTERNATIONAL IMMUNOLOGY

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

(2010) C A Sparks et al.   ONCOGENE

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

(2009) L.-A. Julien et al.   MOLECULAR AND CELLULAR BIOLOGY

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

(2008) A. Y. Choo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA