Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development

(2016) Hong-Xia Wang et al.   JOURNAL OF IMMUNOLOGY

Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity

(2016) Shaojun Xing et al.   NATURE IMMUNOLOGY

mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination

(2016) Hong-Xia Wang et al.   PLOS BIOLOGY

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

(2015) John P. Ray et al.   IMMUNITY

T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses

(2015) Dan Suan et al.   IMMUNITY

ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation

(2015) Erica L. Stone et al.   IMMUNITY

PU.1 Expression in T Follicular Helper Cells Limits CD40L-Dependent Germinal Center B Cell Development

(2015) Olufolakemi Awe et al.   JOURNAL OF IMMUNOLOGY

mTOR and its tight regulation for iNKT cell development and effector function

(2015) Wei Yang et al.   MOLECULAR IMMUNOLOGY

The transcription factor TCF-1 initiates the differentiation of TFH cells during acute viral infection

(2015) Lifan Xu et al.   NATURE IMMUNOLOGY

LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6

(2015) Youn Soo Choi et al.   NATURE IMMUNOLOGY

TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation

(2015) Xinxin Ci et al.   PLoS One

T follicular regulatory cells in the regulation of B cell responses

(2015) Peter T. Sage et al.   TRENDS IN IMMUNOLOGY

MicroRNA-146a regulates ICOS–ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres

(2015) Alvin Pratama et al.   Nature Communications

TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection

(2015) Tuoqi Wu et al.   Cell Reports

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

(2015) Roybel R Ramiscal et al.   eLife

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions

(2014) Jinhong Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Discrete Functions of mTOR Signaling in Invariant NKT Cell Development and NKT17 Fate Decision

(2014) Jun Wei et al.   JOURNAL OF IMMUNOLOGY

Mammalian Target of Rapamycin Complex 1 Orchestrates Invariant NKT Cell Differentiation and Effector Function

(2014) Lianjun Zhang et al.   JOURNAL OF IMMUNOLOGY

Mammalian Target of Rapamycin Complex 2 Regulates Invariant NKT Cell Development and Function Independent of Promyelocytic Leukemia Zinc-Finger

(2014) Nicolas Prevot et al.   JOURNAL OF IMMUNOLOGY

Tuberous Sclerosis 1 Promotes Invariant NKT Cell Anergy and Inhibits Invariant NKT Cell-Mediated Antitumor Immunity

(2014) J. Wu et al.   JOURNAL OF IMMUNOLOGY

T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

(2014) Dan Liu et al.   NATURE

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

(2014) Xindong Liu et al.   NATURE

The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells

(2014) Haikun Wang et al.   NATURE IMMUNOLOGY

Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function

(2014) J. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Receptor-Dependent Activation of mTOR Signaling in T Cells Is Mediated by Carma1 and MALT1, But Not Bcl10

(2014) K. S. Hamilton et al.   Science Signaling

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

(2013) Kai Yang et al.   IMMUNITY

Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype

(2013) Dirk Baumjohann et al.   IMMUNITY

TSC1 regulates the balance between effector and regulatory T cells

(2013) Yoon Park et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression

(2013) Dirk Baumjohann et al.   NATURE IMMUNOLOGY

MicroRNAs of the miR-17∼92 family are critical regulators of TFH differentiation

(2013) Seung Goo Kang et al.   NATURE IMMUNOLOGY

The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus

(2013) Rachael Keating et al.   NATURE IMMUNOLOGY

Regulation of mature T cell responses by the Wnt signaling pathway

(2012) Hai-Hui Xue et al.   Annals of the New York Academy of Sciences

The Role and Regulation of mTOR in T-Lymphocyte Function

(2012) Thomas F. O’Brien et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Regulation of mast cell survival and function by tuberous sclerosis complex 1

(2012) J. Shin et al.   BLOOD

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Temporal Changes in PTEN and mTORC2 Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Suppression

(2012) Jeffrey A. Magee et al.   Cell Stem Cell

STAT5 is a potent negative regulator of TFHcell differentiation

(2012) Robert J. Johnston et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Follicular helper T cells in immunity and systemic autoimmunity

(2012) Joseph E. Craft   Nature Reviews Rheumatology

TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8+ T Cell Survival and Homeostasis in Mice

(2012) Lianjun Zhang et al.   PLoS One

Tumor suppressor TSC1 is critical for T-cell anergy

(2012) D.-L. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative regulation of mTOR activation by diacylglycerol kinases

(2011) B. K. Gorentla et al.   BLOOD

Regulation of T-cell survival and mitochondrial homeostasis by TSC1

(2011) Thomas F. O'Brien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

(2011) Steven M. Kerfoot et al.   IMMUNITY

Functional and Epigenetic Studies Reveal Multistep Differentiation and Plasticity of In Vitro-Generated and In Vivo-Derived Follicular T Helper Cells

(2011) Kristina T. Lu et al.   IMMUNITY

The Tuberous Sclerosis Complex-Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells

(2011) Q. Wu et al.   JOURNAL OF IMMUNOLOGY

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

(2011) Kai Yang et al.   NATURE IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Noncanonical NF- B regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development

(2011) H. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

Follicular Helper T Cell Differentiation Requires Continuous Antigen Presentation that Is Independent of Unique B Cell Signaling

(2010) Elissa K. Deenick et al.   IMMUNITY

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

Phosphoinositide 3-Kinase Activity in T Cells Regulates the Magnitude of the Germinal Center Reaction

(2010) J. Rolf et al.   JOURNAL OF IMMUNOLOGY

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

GSK3 signalling in neural development

(2010) Eun-Mi Hur et al.   NATURE REVIEWS NEUROSCIENCE

Human Dendritic Cells Induce the Differentiation of Interleukin-21-Producing T Follicular Helper-like Cells through Interleukin-12

(2009) Nathalie Schmitt et al.   IMMUNITY

Follicular Helper T Cells: Lineage and Location

(2009) Nicolas Fazilleau et al.   IMMUNITY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

(2009) Nicolas Fazilleau et al.   NATURE IMMUNOLOGY

Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase

(2009) M. Gigoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

(2008) Alexis Vogelzang et al.   IMMUNITY

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY