Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications

The Psychomotor Vigilance Task: Role in the Diagnosis of Hepatic Encephalopathy and Relationship with Driving Ability

(2019) Chiara Formentin et al.   JOURNAL OF HEPATOLOGY

Systemic inflammation without gliosis mediates cognitive deficits through impaired BDNF expression in bile duct ligation model of hepatic encephalopathy

(2018) Saurabh Dhanda et al.   BRAIN BEHAVIOR AND IMMUNITY

Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats

(2018) Andrea Cabrera-Pastor et al.   BRAIN BEHAVIOR AND IMMUNITY

Direct comparison of the thioacetamide and azoxymethane models of Type A hepatic encephalopathy in mice

(2018) Stephanie Grant et al.   GENE EXPRESSION

Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms

(2018) Lucas Taoro-Gonzalez et al.   Journal of Neuroinflammation

Histological Features of Cerebellar Neuropathology in Patients With Alcoholic and Nonalcoholic Steatohepatitis

(2018) Tiziano Balzano et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons

(2018) Tiziano Balzano et al.   Scientific Reports

Health-Related Quality of Life in Chronic Liver Diseases: A Strong Impact of Hand Grip Strength

(2018) Hiroki Nishikawa et al.   Journal of Clinical Medicine

Protective role of chrysin on thioacetamide-induced hepatic encephalopathy in rats

(2018) Salma A. El-Marasy et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Minimal hepatic encephalopathy is associated with expansion and activation of CD4+CD28−, Th22 and Tfh and B lymphocytes

(2017) Alba Mangas-Losada et al.   Scientific Reports

The PHES battery does not detect all cirrhotic patients with early neurological deficits, which are different in different patients

(2017) Carla Giménez-Garzó et al.   PLoS One

In vivo administration of extracellular cGMP normalizes TNF-α and membrane expression of AMPA receptors in hippocampus and spatial reference memory but not IL-1β, NMDA receptors in membrane and working memory in hyperammonemic rats

(2016) Andrea Cabrera-Pastor et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia

(2016) Vicente Hernandez-Rabaza et al.   Journal of Neuroinflammation

Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain

(2016) Raffaella Moretti et al.   Journal of Neuroinflammation

Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy

(2016) Sherry Dadsetan et al.   Journal of Neuroinflammation

Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane

(2016) Vicente Hernández-Rabaza et al.   Journal of Neuroinflammation

18F-DPA-714 PET Imaging for Detecting Neuroinflammation in Rats with Chronic Hepatic Encephalopathy

(2016) Xiang Kong et al.   Theranostics

Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy

(2016) Sherry Dadsetan et al.   Frontiers in Molecular Neuroscience

Extracellular cGMP Modulates Learning Biphasically by Modulating Glycine Receptors, CaMKII and Glutamate-Nitric Oxide-cGMP Pathway

(2016) Andrea Cabrera-Pastor et al.   Scientific Reports

Role of dopaminergic and serotonergic neurotransmitters in behavioral alterations observed in rodent model of hepatic encephalopathy

(2015) Saurabh Dhanda et al.   BEHAVIOURAL BRAIN RESEARCH

Involvement of AMPK, IKβα-NFκB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model

(2015) Ana Karolina Santana Nunes et al.   BRAIN RESEARCH

IL-15 Amplifies the Pathogenic Properties of CD4+CD28−T Cells in Multiple Sclerosis

(2015) Bieke Broux et al.   JOURNAL OF IMMUNOLOGY

Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

(2015) Vicente Hernandez-Rabaza et al.   Journal of Neuroinflammation

Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition

(2015) Christina Alves Peixoto et al.   MEDIATORS OF INFLAMMATION

Decreased levels of guanosine 3′, 5′-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease

(2015) Ana Ugarte et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Pregnenolone Sulfate Restores the Glutamate-Nitric-Oxide-cGMP Pathway and Extracellular GABA in Cerebellum and Learning and Motor Coordination in Hyperammonemic Rats

(2013) Alba Gonzalez-Usano et al.   ACS Chemical Neuroscience

Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice

(2013) Junfang Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Activation of the canonical nuclear factor-κB pathway is involved in isoflurane-induced hippocampal interleukin-1β elevation and the resultant cognitive deficits in aged rats

(2013) Zheng-Qian Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions

(2013) Paula Pifarré et al.   EXPERIMENTAL NEUROLOGY

Microglial proliferation in the brain of chronic alcoholics with hepatic encephalopathy

(2013) Claude V. Dennis et al.   METABOLIC BRAIN DISEASE

Hepatic encephalopathy: effects of liver failure on brain function

(2013) Vicente Felipo   NATURE REVIEWS NEUROSCIENCE

Preventive effect of N-acetyl-L-cysteine on oxidative stress and cognitive impairment in hepatic encephalopathy following bile ductligation

(2012) Saurabh Dhanda et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of CCL20 expression in astrocytes by IL-6 and IL-17

(2012) Gordon P. Meares et al.   GLIA

Behavioral and biochemical characterization of rats treated chronically with thioacetamide: proposal of an animal model for hepatic encephalopathy associated with cirrhosis

(2012) Hiroshi Kawai et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

CSF Concentrations of cAMP and cGMP Are Lower in Patients with Creutzfeldt-Jakob Disease but Not Parkinson's Disease and Amyotrophic Lateral Sclerosis

(2012) Patrick Oeckl et al.   PLoS One

Pathogenic features of CD4+CD28– T cells in immune disorders

(2012) Bieke Broux et al.   TRENDS IN MOLECULAR MEDICINE

Sildenafil (Viagra) ameliorates clinical symptoms and neuropathology in a mouse model of multiple sclerosis

(2011) Paula Pifarre et al.   ACTA NEUROPATHOLOGICA

Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease

(2011) M Cuadrado-Tejedor et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microglia activation in hepatic encephalopathy in rats and humans

(2011) Irina Zemtsova et al.   HEPATOLOGY

Patients with minimal hepatic encephalopathy show impaired mismatch negativity correlating with reduced performance in attention tests

(2011) Vicente Felipo et al.   HEPATOLOGY

CX3CR1 drives cytotoxic CD4+CD28− T cells into the brain of multiple sclerosis patients

(2011) Bieke Broux et al.   JOURNAL OF AUTOIMMUNITY

The Supplementation of Acetyl-l-Carnitine Decreases Fatigue and Increases Quality of Life in Patients with Hepatitis C Treated with Pegylated Interferon-α 2b Plus Ribavirin

(2011) Michele Malaguarnera et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy

(2011) Vicente Felipo et al.   METABOLIC BRAIN DISEASE

Decreased hepatic peroxisome proliferator-activated receptor-γ contributes to increased sensitivity to endotoxin in obstructive jaundice

(2011) Xin Lv   WORLD JOURNAL OF GASTROENTEROLOGY

Minimal Hepatic Encephalopathy Is Associated With Falls

(2010) Eva Román et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

AMPA receptor trafficking and learning

(2010) J. Keifer et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Hyperammonemia Induces Neuroinflammation That Contributes to Cognitive Impairment in Rats With Hepatic Encephalopathy

(2010) Regina Rodrigo et al.   GASTROENTEROLOGY

A Role for Calcium-Permeable AMPA Receptors in Synaptic Plasticity and Learning

(2010) Brian J. Wiltgen et al.   PLoS One

Hyperammonemia Increases GABAergic Tone in the Cerebellum but Decreases It in the Rat Cortex

(2009) Omar Cauli et al.   GASTROENTEROLOGY

Minimal hepatic encephalopathy is associated with motor vehicle crashes: The reality beyond the driving test

(2009) Jasmohan S. Bajaj et al.   HEPATOLOGY

IL-6 and IL-18 in Blood May Discriminate Cirrhotic Patients With and Without Minimal Hepatic Encephalopathy

(2009) Carmina Montoliu et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Cell Death after Spinal Cord Injury Is Exacerbated by Rapid TNF -Induced Trafficking of GluR2-Lacking AMPARs to the Plasma Membrane

(2008) A. R. Ferguson et al.   JOURNAL OF NEUROSCIENCE