Article
Biochemistry & Molecular Biology
Ellis Nelissen, Elentina K. Argyrousi, Nick P. Van Goethem, Fuqiang Zhao, Catherine D. G. Hines, Gayathri Swaminath, Michael Gerisch, Joerg Hueser, Peter Sandner, Jos Prickaerts
Summary: The study found that the sGC stimulator vericiguat can enhance long-term memory by increasing hippocampal plasticity and promoting the translocation of oc-AMPA receptors to the cell membrane, while having no effect on blood pressure and cerebral blood volume. Stimulation of sGC may provide a new therapeutic strategy for treating VCI.
Article
Cell Biology
Luca Franchini, Jennifer Stanic, Marta Barzasi, Elisa Zianni, Daniela Mauceri, Monica Diluca, Fabrizio Gardoni
Summary: This study demonstrates a key role for Rph3A in the modulation of structural synaptic plasticity at hippocampal synapses, which correlates with its interactions with both NMDARs and AMPARs.
Article
Biochemistry & Molecular Biology
Denis P. Laryushkin, Sergei A. Maiorov, Valery P. Zinchenko, Valentina N. Mal'tseva, Sergei G. Gaidin, Artem M. Kosenkov
Summary: This study investigates the role of ionotropic glutamate receptors (iGluRs) in the generation of paroxysmal depolarization shift (PDS) and the dependence of PDS pattern on neuronal membrane potential. The results show that external stimuli play a crucial role in PDS induction. AMPA receptors are necessary for PDS generation, while NMDA and kainate receptors modulate paroxysmal activity. Agonists of G(i)-coupled receptors suppress PDS generation, suggesting a potential approach for epilepsy pharmacotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Italia, Elena Ferrari, Monica Diluca, Fabrizio Gardoni
Summary: A prominent feature of neurodegenerative diseases is synaptic dysfunction and spine loss. Misfolded proteins, such as tau and alpha-synuclein, play a critical role in driving synaptic toxicity at excitatory glutamatergic synapses. Understanding the role of these proteins in impairing the function of glutamate receptors can provide insights into the pathology of neurodegenerative diseases.
Article
Engineering, Biomedical
Siddhant Kumarapuram, Ansley J. Kunnath, Anton Omelchenko, Nada N. Boustany, Bonnie L. Firestein
Summary: The stiffness of substrates affects mitochondrial characteristics and dendritic morphology of neurons, with glutamate receptors playing a crucial role in mediating these effects. Neurons grown on softer substrates have smaller and simpler dendritic mitochondria, while neurons grown on stiffer substrates exhibit larger, more complex dendritic mitochondria. The manipulation of NMDA and AMPA receptors on neurons grown on stiffer substrates leads to mitochondrial characteristics resembling those of neurons grown on softer substrates, indicating the important regulatory roles of glutamate receptors in response to substrate stiffness.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Joanna M. Wieronska, Paulina Cieslik, Grzegorz Burnat, Leszek Kalinowski
Summary: The Morris water maze (MWM) is a popular test for spatial memory in rodents. Activators for muscarinic and metabotropic glutamate receptors can prevent cognitive disorders induced by MK-801 in the MWM. MWM learning increases cGMP synthesis in the cortex and hippocampi, which can be reversed by high doses of the investigated compounds.
Article
Immunology
Sandeep K. Mishra, Mahendra Hidau, Shivika Rai
Summary: The study revealed that STZ induced neuroinflammation and astroglial activation by altering the expression of NMDA receptor subunits and downstream calcium signaling molecules. Both Memantine and Ibuprofen exerted anti-inflammatory effects against STZ-induced inflammation by modulating the NMDA receptor-associated downstream calcium signaling cascade, but only Memantine was able to reverse the changes in NMDA receptor subunit expression.
INFLAMMOPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Douglas F. Covey, Alex S. Evers, Yukitoshi Izumi, Jamie L. Maguire, Steven J. Mennerick, Charles F. Zorumski
Summary: Endogenous neurosteroids and synthetic neuroactive steroids are significant targets for therapeutic development in neuropsychiatric disorders. Studies on unnatural enantiomers of key neurosteroids have provided insights into the interactions of synthetic steroids with receptors, ion channels, and intracellular sites of action. The effects of these enantiomers suggest that they may have therapeutic potential that complements or exceeds their natural counterparts.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Rostislav A. Sokolov, Irina V. Mukhina
Summary: Calcium is a crucial intracellular messenger in the brain that regulates various cell processes. In this study, the researchers used a fluorescent probe to investigate spontaneous Ca2+ events (SCEs) in neurons during culture maturation. They found that SCEs exhibited three different amplitude distributions and were dependent on extracellular Ca2+, neuronal network activity, and specific receptors and channels.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Biochemistry & Molecular Biology
Yan Zhang, John-Man-Tak Chu, Gordon-Tin-Chun Wong
Summary: This article reviews how glutamate handling and glutamatergic function are affected by neuroinflammation and their contribution to cognitive impairment. The authors summarize the current data regarding glutamate in neurotransmission, including its receptors and regulation. They also examine the impact of inflammation on glutamate handling and neurotransmission, focusing on changes in glial cells and the effect of cytokines. Finally, they discuss the implications of these changes for perioperative neuroinflammation and perioperative neurocognitive disorders.
Article
Neurosciences
Sebastiano A. Torrisi, Silvia Rizzo, Samuele Laudani, Alessandro Ieraci, Filippo Drago, Gian Marco Leggio
Summary: Several studies have shown that chronic stress has a negative effect on recognition memory, but the effects of acute stress on this cognitive ability have not been well studied. This study aimed to investigate the impact of acute stress on recognition memory consolidation in a sex-dependent manner. The results showed that acute stress did not affect memory performance in male and female mice immediately after training, but it altered memory performance after a 24-hour delay, with sex-dependent effects.
NEUROBIOLOGY OF STRESS
(2023)
Article
Pharmacology & Pharmacy
Parvin Babaei
Summary: Alzheimer's disease is characterized by cognitive dysfunction and synaptic failure, with neurodegeneration negatively correlated with synaptic plasticity. Glutamatergic neurotransmission via NMDA and AMPA receptors is critical for synaptic plasticity, but excessive glutamate concentration can lead to excitotoxicity and neurodegeneration. Imbalances in NMDA and AMPA receptors can cause synaptopathy in AD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biology
Niklas Lonnemann, Shirin Hosseini, Melanie Ohm, Robert Geffers, Karsten Hiller, Charles A. Dinarello, Martin Korte
Summary: IL-37 has immunomodulatory effects in the central nervous system, protecting neuronal structure and function, inhibiting microglial activation, enhancing long-term potentiation, and exerting anti-inflammatory effects in chronic neuroinflammatory conditions like Alzheimer's disease.
Article
Cell Biology
Torquil Jackson, Mohsen Seifi, Dariusz C. Gorecki, Jerome D. Swinny
Summary: Patients with Duchenne muscular dystrophy (DMD) present with neuropsychiatric disorders in addition to muscle pathology, with inflammation involving DMD and dampening of the local immune system in the brain. The neurobiological basis, including the role of different dystrophins, remains poorly understood.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Giulia Fani, Chiara Ester La Torre, Roberta Cascella, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti
Summary: Alzheimer's disease is characterized by the accumulation of amyloid beta (A beta) peptide in the brain, which leads to the formation of senile plaques. The aggregation process of A beta also generates smaller misfolded oligomers that contribute to disease progression. These oligomers interact with cell membranes, increasing intracellular Ca2+ levels and producing reactive oxygen species (ROS). Our study found that the increase in intracellular Ca2+ occurs faster than the increase in ROS levels after exposure to misfolded protein oligomers. Removing Ca2+ from the cell medium prevents the increase in intracellular Ca2+ and abolishes ROS production. Treating cells with antioxidant agents prevents ROS formation, but does not prevent the initial increase in Ca2+, allowing the cells to restore normal calcium levels. These findings suggest that Ca2+ influx triggers ROS production in cells challenged by aberrant protein oligomers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Clinical Neurology
Yaiza M. Arenas, Tiziano Balzano, Gergana Ivaylova, Marta Llansola, Vicente Felipo
Summary: Chronic hyperammonaemia induces neuroinflammation and motor incoordination in hepatic encephalopathy, and this study identifies the involvement of the S1PR2-CCL2-BDNF-TrkB pathway. Blocking S1PR2 can alleviate neuroinflammation and restore motor coordination.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Tiziano Balzano, Noelia Esteban-Garcia, Javier Blesa
Summary: A key event in Parkinson's disease is the spreading of alpha-synuclein between neurons. Other characteristics of the disease include neurodegeneration, glial activation, and immune cell infiltration in vulnerable brain regions. Preclinical models can mimic most aspects of Parkinson's disease, but understanding individual differences between models is crucial for proper interpretation of results and influencing experimental outcomes.
EXPERT OPINION ON DRUG DISCOVERY
(2023)
Article
Immunology
Paula Izquierdo-Altarejos, Andrea Cabrera-Pastor, Mar Martinez-Garcia, Carlos Sanchez-Huertas, Alberto Hernandez, Victoria Moreno-Manzano, Vicente Felipo
Summary: Chronic hyperammonemia leads to neuroinflammation, causing cognitive impairment. Extracellular vesicles from mesenchymal stem cells can reduce neuroinflammation. In this study, it was found that treatment with these vesicles restores cognitive function in hyperammonemic rats and the underlying mechanism involves TGF beta signaling.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Paula Izquierdo-Altarejos, Mar Martinez-Garcia, Vicente Felipo
Summary: Patients with liver cirrhosis may experience cognitive impairment due to hyperammonemia and peripheral inflammation, which can also be replicated in rats with chronic hyperammonemia. Neuroinflammation in the hippocampus, caused by peripheral inflammation, alters neurotransmission and leads to cognitive impairment. Extracellular vesicles (EVs) from peripheral blood are believed to play a role in transmitting these peripheral alterations to the brain.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Clinical Neurology
Paola Leone, Yaiza M. Arenas, Tiziano Balzano, Gergana Mincheva, Mar Martinez-Garcia, Carmina Montoliu, Marta Llansola, Vicente Felipo
Summary: This study investigated the presence of neuroinflammation, apoptosis, and neuronal loss in the hippocampus of patients with liver cirrhosis and steatohepatitis. The results showed that patients with steatohepatitis exhibited glial activation, immune cell infiltration, apoptosis, and neuronal loss, while cirrhotic patients only showed glial activation and neuronal loss. These findings may explain the irreversible cognitive impairments observed in hepatic encephalopathy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alessandra Fiorillo, Juan-Jose Gallego, Franc Casanova-Ferrer, Carla Gimenez-Garzo, Amparo Urios, Maria-Pilar Ballester, Lucia Durban, Maria-Pilar Rios, Javier Megias, Teresa San Miguel, Elena Kosenko, Desamparados Escudero-Garcia, Salvador Benlloch, Vicente Felipo, Carmina Montoliu
Summary: Patients with NAFLD may experience mild cognitive impairment (MCI), and this study identified specific alterations in the immune system that are associated with neurological changes in MCI patients with NAFLD, which may help improve and restore cognitive functions and quality of life in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Yaiza M. Arenas, Vicente Felipo
Summary: Chronic hyperammonemia is a major cause of cognitive and motor impairment in hepatic encephalopathy patients. This study aimed to investigate the mechanism involving BDNF, TrkB, NF-kappa B, and various proteins in hyperammonemic rats. The results showed that increased BDNF levels enhanced TrkB activation, leading to PI3K-AKT-NF-kappa B pathway activation and increased content of glutaminase I, HMGB1, and TNF alpha. Blocking TrkB, PI3K, or components of the TNFR1-S1PR2-CCR2-BDNF-TrkB pathway reversed these changes. This TrkB-PI3K-AKT-NF-kappa B pathway activation may contribute to Purkinje neuron dysfunction and motor impairment in hyperammonemic rats and cirrhotic patients with hepatic encephalopathy.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tiziano Balzano
Summary: Hepatic encephalopathy (HE) is a reversible neurocognitive syndrome in patients with liver disease. Current therapies focus on reducing ammonia production or increasing its elimination. Only lactulose and rifaximin have been approved for HE treatment, while other potential treatments are limited. This review summarizes ongoing clinical trials for HE treatment, with most agents in phase II or III. These include familiar drugs like lactulose and rifaximin, as well as new entries like fecal microbiota transplantation and equine anti-thymocyte globulin. If successful, these drugs could provide alternative options for ineffective therapies and improve the quality of life for HE patients.
NEUROCHEMICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Javier Blesa, Jose A. Pineda-Pardo, Ken-ichi Inoue, Carmen Gasca-Salas, Tiziano Balzano, Natalia Lopez-Gonzalez Del Rey, Alejandro Reinares-Sebastian, Noelia Esteban-Garcia, Rafael Rodriguez-Rojas, Raquel Marquez, Maria Ciorraga, Marta del Alamo, Lina Garcia-Canamaque, Santiago Ruiz de Aguiar, Itay Rachmilevitch, Ines Trigo-Damas, Masahiko Takada, Jose A. Obeso
Summary: Successful blood-brain barrier opening and targeted delivery of adeno-associated virus serotype 9 vectors into brain regions involved in Parkinson's disease were achieved using low-intensity focused ultrasound. Neuronal green fluorescent protein expression was observed specifically in regions with confirmed blood-brain barrier opening. This less-invasive methodology could potentially revolutionize gene therapy for neurodegenerative disorders.
Review
Pharmacology & Pharmacy
Tiziano Balzano, Marta Llansola, Yaiza M. Arenas, Paula Izquierdo-Altarejos, Vicente Felipo
Summary: Hepatic encephalopathy is a neuropsychiatric syndrome associated with liver disease. Current treatments primarily focus on modulating gut microbiota or reducing ammonia levels, but their effectiveness is limited. Pre-clinical research suggests that targeting peripheral inflammation, neuroinflammation, or neurotransmission may provide new therapeutic options for HE. However, there is a lack of translation of research advances into clinical trials.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Gastroenterology & Hepatology
Yaiza M. Arenas, Paula Izquierdo-Altarejos, Mar Martinez-Garcia, Carla Gimenez-Garzo, Gergana Mincheva, Magnus Doverskog, David E. J. Jones, Tiziano Balzano, Marta Llansola, Vicente Felipo
Summary: Golexanolone treatment may have beneficial effects in improving fatigue, motor, and cognitive impairment in patients with the chronic cholestatic liver disease PBC.
LIVER INTERNATIONAL
(2023)
Meeting Abstract
Clinical Neurology
M. Moreno-Gomez, D. Humanes-Valera, J. Pardo-Valencia, N. Mercado-Garcia, B. Pro-Sanchez, A. Revuelto-Gonzalez, T. Balzano, J. Blesa, A. Bortolozzi, J. A. Obeso, G. Foffani
MOVEMENT DISORDERS
(2022)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)