How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy

Structure of potassium channels

(2015) Qie Kuang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The molecular and cellular basis of thermosensation in mammals

(2015) Radhika Palkar et al.   CURRENT OPINION IN NEUROBIOLOGY

Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

TRPA1 as a drug target—promise and challenges

(2015) Jun Chen et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

L596–W733 bond between the start of the S4–S5 linker and the TRP box stabilizes the closed state of TRPV4 channel

(2015) Jinfeng Teng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction between the Linker, Pre-S1, and TRP Domains Determines Folding, Assembly, and Trafficking of TRPV Channels

(2015) Anna Garcia-Elias et al.   STRUCTURE

Molecular Basis Determining Inhibition/Activation of Nociceptive Receptor TRPA1 Protein

(2014) Nagako Banzawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Significant Amino Acids in Multiple Transmembrane Domains of Human Transient Receptor Potential Ankyrin 1 (TRPA1) for Activation by Eudesmol, an Oxygenized Sesquiterpene in Hop Essential Oil

(2014) Kazuaki Ohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery, Optimization, and Biological Evaluation of 5-(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists

(2014) Lisa Rooney et al.   JOURNAL OF MEDICINAL CHEMISTRY

Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six

(2014) Sairam Jabba et al.   NEURON

Structural basis of diverse membrane target recognitions by ankyrins

(2014) Chao Wang et al.   eLife

Characterization of a Ligand Binding Site in the Human Transient Receptor Potential Ankyrin 1 Pore

(2013) Göran Klement et al.   BIOPHYSICAL JOURNAL

Novel Therapeutic Strategy to Prevent Chemotherapy-Induced Persistent Sensory Neuropathy By TRPA1 Blockade

(2013) G. Trevisan et al.   CANCER RESEARCH

A NOMPC-Dependent Membrane-Microtubule Connector Is a Candidate for the Gating Spring in Fly Mechanoreceptors

(2013) Xin Liang et al.   CURRENT BIOLOGY

Identification of Molecular Determinants for a Potent Mammalian TRPA1 Antagonist by Utilizing Species Differences

(2013) Kazumasa Nakatsuka et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity

(2013) Masayuki Takaishi et al.   Journal of Physiological Sciences

Ion channel seen by electron microscopy

(2013) Richard Henderson   NATURE

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

TRPA1: A Gatekeeper for Inflammation

(2012) Diana M. Bautista et al.   Annual Review of Physiology

Differential Expression and Functionality of TRPA1 Protein Genetic Variants in Conditions of Thermal Stimulation

(2012) Denisa May et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-terminal Acidic Cluster Is Involved in Ca2+-induced Regulation of Human Transient Receptor Potential Ankyrin 1 Channel

(2012) Lucie Sura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct properties of Ca2+–calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel

(2012) Sze-Yi Lau et al.   JOURNAL OF GENERAL PHYSIOLOGY

TRPA1 Is Functionally Expressed Primarily by IB4-Binding, Non-Peptidergic Mouse and Rat Sensory Neurons

(2012) Marie E. Barabas et al.   PLoS One

Thermosensory and Nonthermosensory Isoforms of Drosophila melanogaster TRPA1 Reveal Heat-Sensor Domains of a ThermoTRP Channel

(2012) Lixian Zhong et al.   Cell Reports

The Dynamic TRPA1 Channel: A Suitable Pharmacological Pain Target?

(2011) Sheldon R. Garrison et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Molecular Architecture and Subunit Organization of TRPA1 Ion Channel Revealed by Electron Microscopy

(2011) Teresa L. Cvetkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification ofin VivoDisulfide Conformation of TRPA1 Ion Channel

(2011) Liwen Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila

(2011) Kyeongjin Kang et al.   NATURE

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

(2011) Jun Chen et al.   PAIN

Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli

(2011) J. F. Cordero-Morales et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation

(2010) T. G. Banke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

TRPA1 Contributes to Cold Hypersensitivity

(2010) D. del Camino et al.   JOURNAL OF NEUROSCIENCE

Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception

(2010) Kyeongjin Kang et al.   NATURE

Molecular basis of infrared detection by snakes

(2010) Elena O. Gracheva et al.   NATURE

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

(2010) Barbara Kremeyer et al.   NEURON

Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons

(2010) S. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of Mechanical Hypersensitivity by an Antagonist of the TRPA1 Ion Channel in Diabetic Animals

(2009) Hong Wei et al.   ANESTHESIOLOGY

Pore Dilation Occurs in TRPA1 but Not in TRPM8 Channels

(2009) Jun Chen et al.   Molecular Pain

The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions

(2008) Yuanyuan Y. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels

(2008) B. Xiao et al.   JOURNAL OF NEUROSCIENCE

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

(2008) D. A. Andersson et al.   JOURNAL OF NEUROSCIENCE

A primer on ankyrin repeat function in TRP channels and beyond

(2008) Rachelle Gaudet   Molecular BioSystems

HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity

(2008) Samer R Eid et al.   Molecular Pain

An internal thermal sensor controlling temperature preference in Drosophila

(2008) Fumika N. Hamada et al.   NATURE

General anesthetics activate a nociceptive ion channel to enhance pain and inflammation

(2008) J. A. Matta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA