Identification of Molecular Determinants for a Potent Mammalian TRPA1 Antagonist by Utilizing Species Differences

Analysis of Transient Receptor Potential Ankyrin 1 (TRPA1) in Frogs and Lizards Illuminates Both Nociceptive Heat and Chemical Sensitivities and Coexpression with TRP Vanilloid 1 (TRPV1) in Ancestral Vertebrates

(2012) Shigeru Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Capsaicin Receptor TRPV1 Is a Crucial Mediator of the Noxious Effects of Mustard Oil

(2011) Wouter Everaerts et al.   CURRENT BIOLOGY

Molecular Cloning and Functional Characterization ofXenopus tropicalisFrog Transient Receptor Potential Vanilloid 1 Reveal Its Functional Evolution for Heat, Acid, and Capsaicin Sensitivities in Terrestrial Vertebrates

(2011) Masashi Ohkita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

(2011) Jun Chen et al.   PAIN

TRPA1 antagonists as potential analgesic drugs

(2011) E.L. Andrade et al.   PHARMACOLOGY & THERAPEUTICS

Evolution of Vertebrate Transient Receptor Potential Vanilloid 3 Channels: Opposite Temperature Sensitivity between Mammals and Western Clawed Frogs

(2011) Shigeru Saito et al.   PLoS Genetics

The Met268Pro Mutation of Mouse TRPA1 Changes the Effect of Caffeine from Activation to Suppression

(2010) Katsuhiro Nagatomo et al.   BIOPHYSICAL JOURNAL

Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1

(2010) Qihai Gu et al.   JOURNAL OF APPLIED PHYSIOLOGY

TRPA1 Modulation of Spontaneous and Mechanically Evoked Firing of Spinal Neurons in Uninjured, Osteoarthritic, and Inflamed Rats

(2010) Steve McGaraughty et al.   Molecular Pain

Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat

(2010) Hong Wei et al.   NEUROSCIENCE LETTERS

TRPA1 and Cold Transduction: An Unresolved Issue?

(2009) Ombretta Caspani et al.   JOURNAL OF GENERAL PHYSIOLOGY

Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat

(2009) Hong Wei et al.   NEUROPHARMACOLOGY

Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia

(2009) Jin Y. Ro et al.   PAIN

The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation

(2009) Diogo Santos M. da Costa et al.   PAIN

Transient receptor potential A1 mediates an osmotically activated ion channel

(2008) Xu-Feng Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Novel Gating and Sensitizing Mechanism of Capsaicin Receptor (TRPV1)

(2008) Toshio Ohta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels

(2008) B. Xiao et al.   JOURNAL OF NEUROSCIENCE

Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels

(2008) J. Chen et al.   JOURNAL OF NEUROSCIENCE

HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity

(2008) Samer R Eid et al.   Molecular Pain

Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels

(2008) K. Nagatomo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA