Journal
CANCER CELL
Volume 17, Issue 1, Pages 5-6Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2009.12.032
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Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.
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