Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2

Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss

(2015) Deug-Nam Kwon et al.   Aging-US

SIRT3 deficiency impairs mitochondrial and contractile function in the heart

(2015) Christoph Koentges et al.   BASIC RESEARCH IN CARDIOLOGY

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

(2015) Stephan Winnik et al.   EUROPEAN HEART JOURNAL

Skeletal muscle Sirt3 expression and mitochondrial respiration are regulated by a prenatal low-protein diet

(2015) Kate J. Claycombe et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia

(2015) P. Rangarajan et al.   NEUROSCIENCE

Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function and Pulmonary Arterial Hypertension in Rodents and Humans

(2014) Roxane Paulin et al.   Cell Metabolism

Sirt3 Protects Cortical Neurons against Oxidative Stress via Regulating Mitochondrial Ca2+ and Mitochondrial Biogenesis

(2014) Shu-Hui Dai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DrosophilaSirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity

(2014) Motiur Rahman et al.   JOURNAL OF CELL BIOLOGY

Regulation of Skeletal Muscle Oxidative Capacity and Muscle Mass by SIRT3

(2014) Ligen Lin et al.   PLoS One

Sirtuins: guardians of mammalian healthspan

(2014) William Giblin et al.   TRENDS IN GENETICS

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

(2013) Stephan Winnik et al.   BASIC RESEARCH IN CARDIOLOGY

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity

(2013) Nicola Schäfer et al.   EUROPEAN HEART JOURNAL

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

(2013) Anne H.H. Tseng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Abnormal High-Density Lipoprotein Induces Endothelial Dysfunction via Activation of Toll-like Receptor-2

(2013) Thimoteus Speer et al.   IMMUNITY

Systemic VEGF inhibition accelerates experimental atherosclerosis and disrupts endothelial homeostasis – implications for cardiovascular safety

(2013) Stephan Winnik et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in a p300 and FOXO Regulated Pathway

(2013) Rokhsana Mortuza et al.   PLoS One

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Worldwide Environment of Cardiovascular Disease: Prevalence, Diagnosis, Therapy, and Policy Issues

(2012) Lawrence J. Laslett et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Lifetime Risks of Cardiovascular Disease

(2012) Jarett D. Berry et al.   NEW ENGLAND JOURNAL OF MEDICINE

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

(2012) Pablo J. Fernandez-Marcos et al.   Scientific Reports

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation

(2011) Stephan Winnik et al.   EUROPEAN HEART JOURNAL

The SirT3 Divining Rod Points to Oxidative Stress

(2011) Eric L. Bell et al.   MOLECULAR CELL

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome

(2010) John R. Mercer et al.   CIRCULATION RESEARCH

Sirt3 protects in vitro–fertilized mouse preimplantation embryos against oxidative stress–induced p53-mediated developmental arrest

(2010) Yumiko Kawamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

Genetic Variation in Healthy Oldest-Old

(2009) Julius Halaschek-Wiener et al.   PLoS One

c-Jun N-Terminal Kinase 2 Deficiency Protects Against Hypercholesterolemia-Induced Endothelial Dysfunction and Oxidative Stress

(2008) Elena Osto et al.   CIRCULATION

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA