Article
Biochemistry & Molecular Biology
Li Wang, Jingqian Wang, Xinming Gao, Chen Du, Congcong Hou, Chundan Zhang, Junquan Zhu, Daojun Tang
Summary: This study characterized the expression patterns and potential functions of prohibitin (PHB) in spermatogenesis in Opsariichthys bidens. The results showed that Ob-PHB is mainly located in the mitochondria during spermatogenesis and may participate in the degradation of mitochondria and cell differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Tian-heng Gao, Ming-ming Han, Hui Zhou, Chen-xi Zhu, Ying Yang, Zakaria Zuraini, Yan-Xia Guo, Qi-chen Jiang
Summary: This study investigated the molecular response of the crab Charybdis japonica to berberine hydrochloride exposure using transcriptome sequencing. It was found that berberine hydrochloride activated the immune complement system, increased the survival rate of crabs, and promoted the activity of certain immune enzymes.
Article
Environmental Sciences
Bonian Shui, Yuju Wang, Fangrui Lou, Zhiqiang Han
Summary: In this study, we investigated the genetic regulatory mechanisms of intertidal crustaceans in response to salinity fluctuations using Charybdis japonica as the research species. The results revealed the differential gene expression of C. japonica under different salinity conditions and identified key genes related to adaptation to salinity fluctuations. These findings contribute to a better understanding of the adaptation mechanisms of crustaceans.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Cell Biology
Yan Yin, Liming Zhu, Qiufang Li, Pengbo Zhou, Liang Ma
Summary: Here we demonstrate the essential roles of Cul4a and Cul4b in murine spermatogenesis, with Cul4a promoting meiosis in primary spermatocytes and Cul4b participating in spermiogenesis in secondary spermatocytes. Deletion of both genes leads to severe germ cell defects, indicating functional redundancy between the two CUL4 proteins. Additionally, deleting Cul4b in germ and Sertoli cells affects spermatogenesis and BTB integrity, highlighting the involvement of CUL4B in maintaining germ cell development and BTB structure.
Article
Biochemical Research Methods
Yueshuai Guo, Haotian Zhang, Liping Yao, Yan Li, Chenghao Situ, Jiahao Sha, Daozhen Chen, Xuejiang Guo
Summary: Protein ubiquitination is an important modification during spermatogenesis, with a large-scale analysis of the mouse testis ubiquitome revealing 14,219 ubiquitination sites in 4217 proteins. The ubiquitinated proteins were found to be closely related to meiosis and spermiogenesis, with the identification of 512 ubiquitination regulatory enzymes in testis. Additionally, new ubiquitination sites on testicular histones and ubiquitinated epigenetic factors were discovered, indicating the significance of ubiquitination in epigenetic regulation.
Article
Environmental Sciences
Fangrui Lou, Yuju Wang, Zhiqiang Han, Bonian Shui
Summary: This study explores the molecular regulatory mechanisms of intertidal crustaceans to temperature stresses through transcriptome analysis of Charybdis japonica. Genes related to cell structure, metabolism, and protein folding and hormone synthesis may be involved in the regulation of temperature stress in C. japonica.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Genetics & Heredity
Wensheng Liu, Yinan Zhao, Xiaohua Liu, Xiaoya Zhang, Jiancheng Ding, Yang Li, Yingpu Tian, Haibin Wang, Wen Liu, Zhongxian Lu
Summary: This study identified a testis-specific lncRNA, Rbakdn, with a crucial role in meiosis. Knockdown of Rbakdn inhibits meiosis and disrupts testicular health in mice, highlighting its importance in spermatogenesis. Rbakdn maintains the stability of Ptbp2, an important RNA-binding protein in the regulation of alternative splicing in spermatogenesis.
FRONTIERS IN GENETICS
(2021)
Article
Environmental Sciences
Mingming Han, Yuxin Liu, Tongqing Zhang, Daming Li, Qichen Jiang, Zakaria Zuraini
Summary: Transcriptomic analysis revealed that berberine hydrochloride can activate glutathione metabolism, oxidative phosphorylation, fatty acid degradation, retinol metabolism, pyruvate metabolism, and the hypoxia-inducible factor 1 signaling pathway in acid berberine-infused C. japonicus to adapt to infection with A. hydrophila.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Multidisciplinary Sciences
Geetika Bassi, Suresh Mishra
Summary: Mitochondria play a crucial role in steroidogenesis, particularly in cholesterol transport and P450scc enzyme synthesis. A study on transgenic mice reveals that PHB1 has a regulatory role in Leydig cell steroidogenesis, involving cell signaling, cholesterol homeostasis, and mitochondrial biology.
Article
Microbiology
Kazunori Matsumura, Satoshi Takaki, Teruo Kirikae
Summary: PE_PGRS30 is a member of the PE_PGRS protein family, characterized by a conserved Pro-Glu (PE) domain and a typically polymorphic GC-rich sequence (PGRS) domain. It acts as a virulence factor of Mycobacterium tuberculosis and induces macrophage cell death. The host protein PHB2 was identified as a target molecule, and its overexpression reduced macrophage apoptosis in response to PE_PGRS30. The interaction between PE_PGRS30 and PHB2 occurs via the PGRS and mitochondrial targeting sequences, respectively, and results in mitochondrial dysfunction and cellular apoptosis.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Oncology
Sonia Nunez-Vazquez, Jose Saura-Esteller, Ismael Sanchez-Vera, Emma Guilbaud, Ana M. Cosialls, Gabriel Pons, Jean-Ehrland Ricci, Daniel Iglesias-Serret, Sandrine Marchetti, Joan Gil
Summary: Fluorizoline is a compound that binds prohibitin, triggering apoptosis and inhibiting mitophagy in various cell lines. It can act on both Parkin-dependent and Parkin-independent mitophagy processes.
Article
Biochemistry & Molecular Biology
Beibei Fu, Xiaoyuan Lin, Shun Tan, Rui Zhang, Weiwei Xue, Haiwei Zhang, Shanfu Zhang, Qingting Zhao, Yu Wang, Kelly Feldman, Lei Shi, Shaolin Zhang, Weiqi Nian, Krishna Chaitanya Pavani, Zhifeng Li, Xingsheng Wang, Haibo Wu
Summary: The research reveals that the miR-342-3p/SOCS6 axis plays a crucial role in regulating anti-Mtb immunity and the balance between cell apoptosis and necrosis during Mtb infection, providing new insights for developing host-directed therapies targeting these pathways.
Article
Medicine, Research & Experimental
Qihang Li, Zhiyu Zhang, HongChao Jiang, Jun Hou, Yuhang Chai, Hongxing Nan, Feng Li, Lianghai Wang
Summary: DLEU1 is highly expressed in ESCC tissues and its upregulation is associated with worse prognosis. DLEU1 promotes tumor growth by inhibiting cell apoptosis and stabilizes DYNLL1 by interfering with RNF114-mediated ubiquitination and proteasomal degradation. Additionally, DLEU1 upregulation may be facilitated by promoter hypomethylation. Targeting DLEU1 may enhance sensitivity of ESCC cells to cisplatin-induced death.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oceanography
Lin Chenwen, Gao Xinming, Ni Jie, Zhang Shengshuo, Liu Cheng, Luo Shengyu, Du Chen, Zheng Xuebin, Hou Congcong, Tang Daojun, Zhang Chundan, Zhu Junquan
Summary: This study investigated the cytological features of spermatogenesis in Larimichthys crocea and examined the structure and function of prohibitin (PHB) associated with mitochondrial structure and dynamic. The researchers found that PHB was expressed in the mitochondria during spermatogenesis and proposed a possible relationship between PHB, spermatogenesis, and male fertility.
JOURNAL OF OCEAN UNIVERSITY OF CHINA
(2022)
Article
Cell Biology
Weiqian Chen, Jingjing Song, Siyu Liu, Bufu Tang, Lin Shen, Jinyu Zhu, Shiji Fang, Fazong Wu, Liyun Zheng, Rongfang Qiu, Chunmiao Chen, Yang Gao, Jianfei Tu, Zhongwei Zhao, Jiansong Ji
Summary: The study found that USP9X alleviates the malignant potential of cholangiocarcinoma through upregulation of EGLN3. These findings provide a novel insight into the potential of USP9X as a biomarker or therapeutic/diagnostic target for cholangiocarcinoma.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Review
Genetics & Heredity
Ya-Lan Wei, Wan-Xi Yang
Article
Genetics & Heredity
Ya-Ru Xu, Gao-Yuan Wang, Yi-Chao Zhou, Wan-Xi Yang
Review
Genetics & Heredity
Li Sheng, Shuang-Li Hao, Wan-Xi Yang, Yi Sun
Review
Genetics & Heredity
Ya-Jing Liang, Wan-Xi Yang
Article
Cell Biology
Ya-Lan Wei, Wan-Xi Yang
CELL DEATH & DISEASE
(2019)
Review
Cell Biology
Fei-Da Ni, Shuang-Li Hao, Wan-Xi Yang
CELL DEATH & DISEASE
(2019)
Article
Genetics & Heredity
Ya-Lan Wei, Tong Yang, Tamas Kovacs, Wan-Xi Yang
Review
Genetics & Heredity
Fei-Da Ni, Shuang-Li Hao, Wan-Xi Yang
Review
Genetics & Heredity
Tong Yang, Wan-Xi Yang
Article
Genetics & Heredity
Tong Yang, Bang-Hong Wei, Shuang-Li Hao, Ya-Lan Wei, Wan-Xi Yang
Review
Genetics & Heredity
Yi Xie, Bang-Hong Wei, Fei-Da Ni, Wan-Xi Yang
Summary: This review categorizes the conversion from spermatogonia to spermatocyte into four development processes, focusing on extracellular cues and downstream transcription network. Potential coordination among Dmrt1, Sohlh1/2 and BMP families mediates Ngn3 upregulation, marking progenitor spermatogonia, and retinoic acid acts as a master regulator promoting A1 spermatogonia formation.
Article
Cell Biology
Zhen-Fang Li, Shuang-Li Hao, Lan-Min Wang, Hong-Yu Qi, Jia-Ming Wang, Fu-Qing Tan, Wan-Xi Yang
Summary: This study identified two core components of the mTOR signaling pathway, es-Raptor and es-Rictor, in spermatogenesis of the Chinese mitten crab. These proteins are crucial for maintaining the actin filament network and cell junctions, which are essential for successful sperm production.
CELL AND TISSUE RESEARCH
(2022)
Article
Cell Biology
Zhen-Fang Li, Hong-Yu Qi, Jia-Ming Wang, Zhan Zhao, Fu-Qing Tan, Wan-Xi Yang
Summary: This study cloned mTORC1/rpS6 and mTORC2/PKC proteins from the testis of Eriocheir sinensis for the first time and found that they regulate spermatogenesis in crustaceans through Arp3-mediated actin microfilament organization. These findings reveal the importance of the mTOR signaling pathway in spermatogenesis in arthropods.
CELL AND TISSUE RESEARCH
(2023)
Article
Environmental Sciences
Lan -Min Wang, Ke Jia, Zhen-Fang Li, Hong -Yu Qi, Ding -Xi Liu, Ya-Jing Liang, Shuang-Li Hao, Fu-Qing Tan, Wan-Xi Yang
Summary: Recent studies found that TiO2 nanoparticles (TiO2-NPs) have reproductive toxicity in males, but there are few reports on the toxicity of TiO2-NPs in crustaceans. In this study, freshwater crustacean Eriocheir sinensis was used to investigate the male toxicity of TiO2-NP exposure and its underlying mechanisms. TiO2-NPs of 3 nm and 25 nm at a dose of 30 mg/kg bw induced apoptosis and damage to the haemolymph-testis-barrier (HTB) and seminiferous tubule structure. The mTORC1-mTORC2 imbalance induced by TiO2-NPs was involved in the mechanism of AJ and HTB disruption, resulting in spermatogenesis in E. sinensis.
ENVIRONMENTAL POLLUTION
(2023)
Article
Genetics & Heredity
Anzana Parvin, Shuang-Li Hao, Fu-Qing Tan, Wan-Xi Yang
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
