Axonal degeneration in multiple sclerosis: can we predict and prevent permanent disability?

Imidazol-1-ylethylindazole Voltage-Gated Sodium Channel Ligands Are Neuroprotective during Optic Neuritis in a Mouse Model of Multiple Sclerosis

(2014) Lorcan Browne et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

(2014) Manuel A. Friese et al.   Nature Reviews Neurology

Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions

(2014) A. Klistorner et al.   NEUROLOGY

Neurofilament light and heavy subunits compared as therapeutic biomarkers in multiple sclerosis

(2013) J. Kuhle et al.   ACTA NEUROLOGICA SCANDINAVICA

Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors

(2013) Ranjan Dutta et al.   ANNALS OF NEUROLOGY

Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis

(2013) Sarah Al-Izki et al.   BRAIN

Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride

(2013) Tarunya Arun et al.   BRAIN

Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats

(2013) Christopher Gardner et al.   BRAIN

Risk of multiple sclerosis after optic neuritis in patients with normal baseline brain MRI

(2013) Inês Brás Marques et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Sodium Channels Contribute to Degeneration of Dorsal Root Ganglion Neurites Induced by Mitochondrial Dysfunction in an In Vitro Model of Axonal Injury

(2013) A.-K. Persson et al.   JOURNAL OF NEUROSCIENCE

Immunosuppressive therapy reduces axonal damage in progressive multiple sclerosis

(2013) Markus Axelsson et al.   Multiple Sclerosis Journal

A comparative study of CSF neurofilament light and heavy chain protein in MS

(2013) Jens Kuhle et al.   Multiple Sclerosis Journal

Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain

(2013) Victoria A. Rafalski et al.   NATURE CELL BIOLOGY

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Biomarker Report from the Phase II Lamotrigine Trial in Secondary Progressive MS – Neurofilament as a Surrogate of Disease Progression

(2013) Sharmilee Gnanapavan et al.   PLoS One

Optic Nerve Diffusion Tensor Imaging after Acute Optic Neuritis Predicts Axonal and Visual Outcomes

(2013) Anneke van der Walt et al.   PLoS One

Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis

(2013) Maarten E. Witte et al.   TRENDS IN MOLECULAR MEDICINE

Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation

(2012) Steven Petratos et al.   BRAIN

Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis

(2012) Sung R. Choi et al.   BRAIN

Diffusion abnormality maps in demyelinating disease: Correlations with clinical scores

(2012) Mihaela Onu et al.   EUROPEAN JOURNAL OF RADIOLOGY

Investigating Axonal Damage in Multiple Sclerosis by Diffusion Tensor Spectroscopy

(2012) E. T. Wood et al.   JOURNAL OF NEUROSCIENCE

Accumulation of cortical hyperphosphorylated neurofilaments as a marker of neurodegeneration in multiple sclerosis

(2012) E. Gray et al.   Multiple Sclerosis Journal

The role of mitochondria in axonal degeneration and tissue repair in MS

(2012) J van Horssen et al.   Multiple Sclerosis Journal

CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome

(2012) M Khalil et al.   Multiple Sclerosis Journal

Neurofilaments as biomarkers in multiple sclerosis

(2012) Charlotte E Teunissen et al.   Multiple Sclerosis Journal

Cytoskeletal proteins in the cerebrospinal fluid as biomarker of multiple sclerosis

(2012) Roberto Madeddu et al.   NEUROLOGICAL SCIENCES

Vitamin D in MS: A vitamin for 4 seasons

(2012) A. Ascherio et al.   NEUROLOGY

Motor Protein KIF1A Is Essential for Hippocampal Synaptogenesis and Learning Enhancement in an Enriched Environment

(2012) Makoto Kondo et al.   NEURON

The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment

(2012) Prejaas Tewarie et al.   PLoS One

Multiple sclerosis normal-appearing white matter: Pathology-imaging correlations

(2011) Natalia M. Moll et al.   ANNALS OF NEUROLOGY

Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

(2011) Chris H. Polman et al.   ANNALS OF NEUROLOGY

Redox regulation of cellular stress response in multiple sclerosis

(2011) G. Pennisi et al.   BIOCHEMICAL PHARMACOLOGY

Cortical injury in multiple sclerosis; the role of the immune system

(2011) Caroline A Walker et al.   BMC Neurology

Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis

(2011) Laura Lovato et al.   BRAIN

Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model

(2011) Sandra Vergo et al.   BRAIN

Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis

(2011) Jessica L. Zambonin et al.   BRAIN

Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis

(2011) Owain W. Howell et al.   BRAIN

Whole brain white matter changes revealed by multiple diffusion metrics in multiple sclerosis: A TBSS study

(2011) Yaou Liu et al.   EUROPEAN JOURNAL OF RADIOLOGY

Phosphorylation and Cleavage of the Family of Collapsin Response Mediator Proteins May Play a Central Role in Neurodegeneration after CNS Trauma

(2011) Kasra Taghian et al.   JOURNAL OF NEUROTRAUMA

Neurofilament heavy chain in CSF correlates with relapses and disability in multiple sclerosis

(2011) J. Kuhle et al.   NEUROLOGY

Intrinsic Damage to the Major White Matter Tracts in Patients with Different Clinical Phenotypes of Multiple Sclerosis: A Voxelwise Diffusion-Tensor MR Study

(2011) Paolo Preziosa et al.   RADIOLOGY

Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab

(2010) Martin Gunnarsson et al.   ANNALS OF NEUROLOGY

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

(2010) Graham R. Campbell et al.   ANNALS OF NEUROLOGY

A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis

(2010) Roberta Magliozzi et al.   ANNALS OF NEUROLOGY

Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients

(2010) Ranjan Dutta et al.   ANNALS OF NEUROLOGY

Oral Resveratrol Reduces Neuronal Damage in a Model of Multiple Sclerosis

(2010) Kenneth S Shindler et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Comparison of Diffusion Tensor-Based Tractography and Quantified Brain Atrophy for Analyzing Demyelination and Axonal Loss in MS

(2010) Frauke Fink et al.   JOURNAL OF NEUROIMAGING

Demyelination Increases Axonal Stationary Mitochondrial Size and the Speed of Axonal Mitochondrial Transport

(2010) S. Kiryu-Seo et al.   JOURNAL OF NEUROSCIENCE

Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE

(2010) Marina O Ziehn et al.   LABORATORY INVESTIGATION

Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial

(2010) Raju Kapoor et al.   LANCET NEUROLOGY

Unfolding the long-term pathophysiological processes following an acute inflammatory demyelinating lesion of multiple sclerosis

(2010) Wafaa Zaaraoui et al.   MAGNETIC RESONANCE IMAGING

Focal and diffuse cortical degenerative changes in a marmoset model of multiple sclerosis

(2010) IM Pomeroy et al.   Multiple Sclerosis Journal

Cognition in multiple sclerosis: relevance of lesions, brain atrophy and proton MR spectroscopy

(2010) Antonio Giorgio et al.   NEUROLOGICAL SCIENCES

Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis

(2010) Ranjan Dutta et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial changes within axons in multiple sclerosis

(2009) D. J. Mahad et al.   BRAIN

Long-Term Study of Brain1H-MRS Study in Multiple Sclerosis: Effect of Glatiramer Acetate Therapy on Axonal Metabolic Function and Feasibility of Long-Term1H-MRS Monitoring in Multiple Sclerosis

(2009) Omar Khan et al.   JOURNAL OF NEUROIMAGING

A diffusion tensor MRI study of cervical cord damage in benign and secondary progressive multiple sclerosis patients

(2009) B Benedetti et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage

(2009) Jin Young Kim et al.   NATURE NEUROSCIENCE

Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals

(2009) T. Derfuss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axonal loss and myelin in early ON loss in postacute optic neuritis

(2008) Alexander Klistorner et al.   ANNALS OF NEUROLOGY

Substantial Archaeocortical Atrophy and Neuronal Loss in Multiple Sclerosis

(2008) Dimitrios Papadopoulos et al.   BRAIN PATHOLOGY

Prevention of axonal injury using calpain inhibitor in chronic progressive experimental autoimmune encephalomyelitis

(2008) Getaw Worku Hassen et al.   BRAIN RESEARCH

Activation of Calpain and Caspase Pathways in Demyelination and Neurodegeneration in Animal Model of Multiple Sclerosis

(2008) Arabinda Das et al.   CNS & Neurological Disorders-Drug Targets

Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration

(2008) P. S. Vosler et al.   MOLECULAR NEUROBIOLOGY

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

(2008) Siming Shen et al.   NATURE NEUROSCIENCE

Axonal loss and gray matter pathology as a direct result of autoimmunity to neurofilaments

(2008) Ruth Huizinga et al.   NEUROBIOLOGY OF DISEASE

Mechanisms of Disease: sodium channels and neuroprotection in multiple sclerosis—current status

(2008) Stephen G Waxman   Nature clinical practice. Neurology

Epileptic seizures and hippocampal damage after cuprizone-induced demyelination in C57BL/6 mice

(2007) Katrin Hoffmann et al.   EXPERIMENTAL NEUROLOGY