Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment

Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model

(2018) Chad A Tagge et al.   BRAIN

Inhibition of histone deacetylase 6 (HDAC6) protects against vincristine-induced peripheral neuropathies and inhibits tumor growth

(2018) Lawrence Van Helleputte et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer’s Disease

(2017) Qian Cai et al.   JOURNAL OF ALZHEIMERS DISEASE

An acetylation–phosphorylation switch that regulates tau aggregation propensity and function

(2017) Yari Carlomagno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoregulation of Tau modulates inhibition of kinesin-1 motility

(2017) Jamie L. Stern et al.   MOLECULAR BIOLOGY OF THE CELL

HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy

(2017) Karen Krukowski et al.   PAIN

Tau association with synaptic vesicles causes presynaptic dysfunction

(2017) Lujia Zhou et al.   Nature Communications

The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology

(2017) Jui-Heng Tseng et al.   Cell Reports

Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy

(2017) Magdalena A. Maj et al.   Frontiers in Molecular Neuroscience

Invasive Cancer Incidence and Survival — United States, 2013

(2017) S. Jane Henley et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy

(2017) Hanna Trzeciakiewicz et al.   Scientific Reports

Pifithrin-μ Prevents Cisplatin-Induced Chemobrain by Preserving Neuronal Mitochondrial Function

(2016) Gabriel S. Chiu et al.   CANCER RESEARCH

Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling

(2016) Yaling Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective HDAC inhibition by ACY-241 enhances the activity of paclitaxel in solid tumor models

(2016) Pengyu Huang et al.   Oncotarget

Neurotoxic Effects of Anthracycline- vs Nonanthracycline-Based Chemotherapy on Cognition in Breast Cancer Survivors

(2016) Shelli R. Kesler et al.   JAMA Oncology

Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice

(2016) Wenjun Zhou et al.   PLoS One

Dual Targeting of Protein Degradation Pathways with the Selective HDAC6 Inhibitor ACY-1215 and Bortezomib Is Synergistic in Lymphoma

(2015) J. E. Amengual et al.   CLINICAL CANCER RESEARCH

Invited review: Neuropathology of tauopathies: principles and practice

(2015) G. G. Kovacs   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Mitochondrial trafficking and anchoring in neurons: New insight and implications

(2014) Zu-Hang Sheng   JOURNAL OF CELL BIOLOGY

The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model

(2014) Qi-Liang Mao-Ying et al.   PLoS One

Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition

(2014) Maj-Linda Selenica et al.   Alzheimers Research & Therapy

Cancer Survivors in the United States: Prevalence across the Survivorship Trajectory and Implications for Care

(2013) J. S. de Moor et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

(2013) Casey Cook et al.   HUMAN MOLECULAR GENETICS

A role for tau at the synapse in Alzheimer's disease pathogenesis

(2013) Amy M. Pooler et al.   NEUROPHARMACOLOGY

Klotho Sensitizes Human Lung Cancer Cell Line to Cisplatin via PI3k/Akt Pathway

(2013) Yan Wang et al.   PLoS One

HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila

(2013) Y. Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

αTAT1 is the major α-tubulin acetyltransferase in mice

(2013) Nereo Kalebic et al.   Nature Communications

Chemotherapy-Related Cognitive Dysfunction

(2012) Jeffrey S. Wefel et al.   Current Neurology and Neuroscience Reports

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

(2012) Nambirajan Govindarajan et al.   EMBO Molecular Medicine

Alterations in Brain Activation During Working Memory Processing Associated With Breast Cancer and Treatment: A Prospective Functional Magnetic Resonance Imaging Study

(2012) Brenna C. McDonald et al.   JOURNAL OF CLINICAL ONCOLOGY

Hyperdynamic Microtubules, Cognitive Deficits, and Pathology Are Improved in Tau Transgenic Mice with Low Doses of the Microtubule-Stabilizing Agent BMS-241027

(2012) D. M. Barten et al.   JOURNAL OF NEUROSCIENCE

A novel GRK2/HDAC6 interaction modulates cell spreading and motility

(2011) Vanesa Lafarga et al.   EMBO JOURNAL

Protein kinase CK2 regulates the formation and clearance of aggresomes in response to stress

(2011) M. Watabe et al.   JOURNAL OF CELL SCIENCE

Longitudinal Assessment of Chemotherapy-Induced Structural Changes in Cerebral White Matter and Its Correlation With Impaired Cognitive Functioning

(2011) Sabine Deprez et al.   JOURNAL OF CLINICAL ONCOLOGY

The puzzle box as a simple and efficient behavioral test for exploring impairments of general cognition and executive functions in mouse models of schizophrenia

(2010) Nada M.-B. Ben Abdallah et al.   EXPERIMENTAL NEUROLOGY

The Role of HDAC6 in Cancer

(2010) Grace I. Aldana-Masangkay et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Neural mechanisms of ageing and cognitive decline

(2010) Nicholas A. Bishop et al.   NATURE

HDAC6 Regulates Mitochondrial Transport in Hippocampal Neurons

(2010) Sigeng Chen et al.   PLoS One

Animal models reveal role for tau phosphorylation in human disease

(2009) Jürgen Götz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Balancing Structure and Function at Hippocampal Dendritic Spines

(2008) Jennifer N Bourne et al.   Annual Review of Neuroscience

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Clinical Patterns and Biological Correlates of Cognitive Dysfunction Associated with Cancer Therapy

(2008) J. Dietrich et al.   ONCOLOGIST