A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

Haemolytic uraemic syndrome

(2017) Fadi Fakhouri et al.   LANCET

The renaissance of complement therapeutics

(2017) Daniel Ricklin et al.   Nature Reviews Nephrology

The mystery behind membrane insertion: a review of the complement membrane attack complex

(2017) Charles Bayly-Jones et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Protection of host cells by complement regulators

(2016) Christoph Q. Schmidt et al.   IMMUNOLOGICAL REVIEWS

Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway

(2016) Janus Asbjørn Schatz-Jakobsen et al.   JOURNAL OF IMMUNOLOGY

Complement in disease: a defence system turning offensive

(2016) Daniel Ricklin et al.   Nature Reviews Nephrology

Structural basis of complement membrane attack complex formation

(2016) Marina Serna et al.   Nature Communications

Eculizumab in the management of paroxysmal nocturnal hemoglobinuria: patient selection and special considerations

(2016) Alejandro Lazo-Langner et al.   Therapeutics and Clinical Risk Management

A Familial C3GN Secondary to Defective C3 Regulation by Complement Receptor 1 and Complement Factor H

(2015) S. Chauvet et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2-year extensions of phase 2 studies

(2015) Christoph Licht et al.   KIDNEY INTERNATIONAL

Anticomplement C5 therapy with eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

(2015) Edwin K.S. Wong et al.   Translational Research

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement Factor B Mutations in Atypical Hemolytic Uremic Syndrome--Disease-Relevant or Benign?

(2014) M. C. Marinozzi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

(2013) M. Frimat et al.   BLOOD

Full functional activity of SSL7 requires binding of both complement C5 and IgA

(2013) Natalie Lorenz et al.   IMMUNOLOGY AND CELL BIOLOGY

The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment

(2012) A. M. Risitano et al.   BLOOD

Crystal Structure of C5b-6 Suggests Structural Basis for Priming Assembly of the Membrane Attack Complex

(2012) Alexander E. Aleshin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5b6 and sC5b9

(2012) Michael A. Hadders et al.   Cell Reports

Complement in health and disease

(2011) Maria V. Carroll et al.   ADVANCED DRUG DELIVERY REVIEWS

Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex

(2011) Nick S Laursen et al.   EMBO JOURNAL

Functional Complement C1q Abnormality Leads to Impaired Immune Complexes and Apoptotic Cell Clearance

(2011) Lubka T. Roumenina et al.   JOURNAL OF IMMUNOLOGY

Targeting Complement C5 in Atypical Hemolytic Uremic Syndrome

(2010) D. J. Salant   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Development of Atypical Hemolytic Uremic Syndrome Depends on Complement C5

(2010) E. G. de Jorge et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus

(2010) Nick S. Laursen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement evasion strategies of pathogens—Acquisition of inhibitors and beyond

(2009) Anna M. Blom et al.   MOLECULAR IMMUNOLOGY

The role of the anaphylatoxins in health and disease

(2009) Andreas Klos et al.   MOLECULAR IMMUNOLOGY