B Cell Siglecs–News on Signaling and Its Interplay With Ligand Binding

Proximity labeling of cis-ligands of CD22/Siglec-2 reveals stepwise α2,6 sialic acid-dependent and -independent interactions

(2018) Amin Alborzian Deh Sheikh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Patient-reported outcomes from a phase 3 randomized controlled trial of inotuzumab ozogamicin versus standard therapy for relapsed/refractory acute lymphoblastic leukemia

(2018) Hagop M. Kantarjian et al.   CANCER

Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia

(2018) Robert J. Kreitman et al.   LEUKEMIA

Efficacy of Epratuzumab, an Anti-CD22 Monoclonal IgG Antibody, in Systemic Lupus Erythematosus Patients With Associated Sjögren's Syndrome

(2018) Jacques-Eric Gottenberg et al.   Arthritis & Rheumatology

Sialic Acid Ligand Binding of CD22 and Siglec-G Determines Distinct B Cell Functions but Is Dispensable for B Cell Tolerance Induction

(2018) Lamia Özgör et al.   JOURNAL OF IMMUNOLOGY

Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans

(2018) N. Giovannone et al.   Nature Communications

Galectin-9 binds IgM-BCR to regulate B cell signaling

(2018) Anh Cao et al.   Nature Communications

CAR-T Cell Therapy for Acute Lymphoblastic Leukemia: Transforming the Treatment of Relapsed and Refractory Disease

(2018) Katherine C. Pehlivan et al.   Current Hematologic Malignancy Reports

Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model

(2017) Kyle J. Bednar et al.   JOURNAL OF IMMUNOLOGY

Murine Red Blood Cells Lack Ligands for B Cell Siglecs, Allowing Strong Activation by Erythrocyte Surface Antigens

(2017) Fernando Spiller et al.   JOURNAL OF IMMUNOLOGY

CD22 Ligands on a Natural N-Glycan Scaffold Efficiently Deliver Toxins to B-Lymphoma Cells

(2017) Wenjie Peng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

(2017) Terry J Fry et al.   NATURE MEDICINE

Molecular basis of human CD22 function and therapeutic targeting

(2017) June Ereño-Orbea et al.   Nature Communications

Efficacy and Safety of Epratuzumab in Moderately to Severely Active Systemic Lupus Erythematosus: Results From Two Phase III Randomized, Double-Blind, Placebo-Controlled Trials

(2017) Megan E. B. Clowse et al.   Arthritis & Rheumatology

CD22 is required for formation of memory B cell precursors within germinal centers

(2017) Craig P. Chappell et al.   PLoS One

Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy

(2016) R. Gardner et al.   BLOOD

Epratuzumab modulates B-cell signaling without affecting B-cell numbers or B-cell functions in a mouse model with humanized CD22

(2016) Lamia Özgör et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Besides an ITIM/SHP-1-dependent pathway, CD22 collaborates with Grb2 and plasma membrane calcium-ATPase in an ITIM/SHP-1-independent pathway of attenuation of Ca2+i signal in B cells

(2016) Jie Chen et al.   Oncotarget

Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells

(2016) Sabrina Gruber et al.   Cell Reports

The nanoscale organization of the B lymphocyte membrane

(2015) Palash Chandra Maity et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Phase I Study of a Bispecific Ligand-Directed Toxin Targeting CD22 and CD19 (DT2219) for Refractory B-cell Malignancies

(2015) V. Bachanova et al.   CLINICAL CANCER RESEARCH

Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling

(2015) F. Gasparrini et al.   EMBO JOURNAL

Antibody recognition of carbohydrate epitopes

(2015) Omid Haji-Ghassemi et al.   GLYCOBIOLOGY

Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man

(2015) Matthew S. Macauley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice

(2015) Jennifer Müller et al.   JOURNAL OF IMMUNOLOGY

An extracatalytic function of CD45 in B cells is mediated by CD22

(2015) Sarah Coughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches

(2015) Takashi Angata et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

(2015) E. Sotillo et al.   Cancer Discovery

Siglecs Induce Tolerance to Cell Surface Antigens by BIM-Dependent Deletion of the Antigen-Reactive B Cells

(2014) Matthew S. Macauley et al.   JOURNAL OF IMMUNOLOGY

The Ligand-Binding Domain of Siglec-G Is Crucial for Its Selective Inhibitory Function on B1 Cells

(2014) S. Hutzler et al.   JOURNAL OF IMMUNOLOGY

Siglec-G Deficiency Leads to More Severe Collagen-Induced Arthritis and Earlier Onset of Lupus-like Symptoms in MRL/lpr Mice

(2014) S. Bokers et al.   JOURNAL OF IMMUNOLOGY

Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing

(2014) Mike Lee et al.   NATURE IMMUNOLOGY

The role of CD22 and Siglec-G in B-cell tolerance and autoimmune disease

(2014) Jennifer Müller et al.   Nature Reviews Rheumatology

Galectin-9 in tumor biology: A jack of multiple trades

(2013) Roy Heusschen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The Actin and Tetraspanin Networks Organize Receptor Nanoclusters to Regulate B Cell Receptor-Mediated Signaling

(2013) Pieta K. Mattila et al.   IMMUNITY

Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis

(2013) Matthew S. Macauley et al.   JOURNAL OF CLINICAL INVESTIGATION

Copresentation of Antigen and Ligands of Siglec-G Induces B Cell Tolerance Independent of CD22

(2013) F. Pfrengle et al.   JOURNAL OF IMMUNOLOGY

Galectin-9 Ameliorates Clinical Severity of MRL/lpr Lupus-Prone Mice by Inducing Plasma Cell Apoptosis Independently of Tim-3

(2013) Masahiro Moritoki et al.   PLoS One

CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling

(2013) J. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-9 Is a Suppressor of T and B Cells and Predicts the Immune Modulatory Potential of Mesenchymal Stromal Cell Preparations

(2013) Christopher Ungerer et al.   STEM CELLS AND DEVELOPMENT

Multifarious roles of sialic acids in immunity

(2012) Ajit Varki et al.   Annals of the New York Academy of Sciences

CD22 ligation inhibits downstream B cell receptor signaling and Ca2+flux upon activation

(2012) N. Sieger et al.   ARTHRITIS AND RHEUMATISM

Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia

(2012) W. Haso et al.   BLOOD

Targeting of CD22-positive B-cell lymphoma cells by synthetic divalent sialic acid analogues

(2012) Astrid Schweizer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human CD22 cannot fully substitute murine CD22 functions in vivo, as shown in a new knockin mouse model

(2012) Miriam Wöhner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins

(2012) S. L. Orr et al.   GLYCOBIOLOGY

Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+signalling

(2011) Jochen A Ackermann et al.   EMBO JOURNAL

Therapeutic potential of Galectin-9 in human disease

(2011) Valerie R. Wiersma et al.   MEDICINAL RESEARCH REVIEWS

T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses

(2011) S. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction

(2011) I. K. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo targeting of B-cell lymphoma with glycan ligands of CD22

(2010) W. C. Chen et al.   BLOOD

The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell Receptor

(2010) Bebhinn Treanor et al.   IMMUNITY

CD22 x Siglec-G Double-Deficient Mice Have Massively Increased B1 Cell Numbers and Develop Systemic Autoimmunity

(2010) J. Jellusova et al.   JOURNAL OF IMMUNOLOGY

Siglec-G Regulates B1 Cell Survival and Selection

(2010) J. Jellusova et al.   JOURNAL OF IMMUNOLOGY

CD22 Is a Recycling Receptor That Can Shuttle Cargo between the Cell Surface and Endosomal Compartments of B Cells

(2010) M. K. O'Reilly et al.   JOURNAL OF IMMUNOLOGY

In Situ transLigands of CD22 Identified by Glycan-Protein Photocross-linking-enabled Proteomics

(2010) T. N. C. Ramya et al.   MOLECULAR & CELLULAR PROTEOMICS

CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

(2009) Michelle L. Hermiston et al.   IMMUNOLOGICAL REVIEWS

Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane

(2009) Patrick Lajoie et al.   JOURNAL OF CELL BIOLOGY

Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo

(2009) Bao Hoa Duong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Augmented TLR9-induced Btk activation in PIR-B–deficient B-1 cells provokes excessive autoantibody production and autoimmunity

(2009) Tomohiro Kubo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sialylated multivalent antigens engage CD22in transand inhibit B cell activation

(2009) Adam H. Courtney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B cells in autoimmunity

(2009) Thomas Dörner et al.   ARTHRITIS RESEARCH & THERAPY

Subdiffraction-Resolution Fluorescence Imaging with Conventional Fluorescent Probes

(2008) Mike Heilemann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modulation of peripheral B cell tolerance by CD72 in a murine model

(2008) Daniel Hsieh-Hsin Li et al.   ARTHRITIS AND RHEUMATISM

Galectin–glycan lattices regulate cell-surface glycoprotein organization and signalling: Table 1

(2008) Omai B. Garner et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Characterizing the glycome of the mammalian immune system

(2008) Stuart M Haslam et al.   IMMUNOLOGY AND CELL BIOLOGY

Whole-cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution

(2008) Bo Huang et al.   NATURE METHODS