Therapeutic potential of Galectin-9 in human disease

TIMgenes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity

(2015) Gordon J. Freeman et al.   IMMUNOLOGICAL REVIEWS

Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions

(2014) K. Nagahara et al.   JOURNAL OF IMMUNOLOGY

The inhibition of the T-cell immunoglobulin and mucin domain 3 (Tim3) pathway enhances the efficacy of tumor vaccine

(2010) Mi Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interleukin-6 as a Therapeutic Target in Candidate Inflammatory Diseases

(2010) N Nishimoto   CLINICAL PHARMACOLOGY & THERAPEUTICS

Myeloid-derived suppressor cell heterogeneity and subset definition

(2010) Elisa Peranzoni et al.   CURRENT OPINION IN IMMUNOLOGY

Galectin-9 ameliorates acute GVH disease through the induction of T-cell apoptosis

(2010) Kazuki Sakai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Galectin multimerization and lattice formation are regulated by linker region structure

(2010) L. A. Earl et al.   GLYCOBIOLOGY

Involvement of Galectin-9 in Lung Eosinophilia in Patients with Eosinophilic Pneumonia

(2010) Shigeki Katoh et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

N-domain of human adhesion/growth-regulatory galectin-9: Preference for distinct conformers and non-sialylated N-glycans and detection of ligand-induced structural changes in crystal and solution

(2010) Dolores Solís et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

X-ray Structures of Human Galectin-9 C-terminal Domain in Complexes with a Biantennary Oligosaccharide and Sialyllactose

(2010) Hiromi Yoshida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion

(2010) Xiaoyuan Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tim3 binding to galectin-9 stimulates antimicrobial immunity

(2010) Pushpa Jayaraman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells

(2010) V. Dardalhon et al.   JOURNAL OF IMMUNOLOGY

TIM-3: A Novel Regulatory Molecule of Alloimmune Activation

(2010) O. Boenisch et al.   JOURNAL OF IMMUNOLOGY

Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways

(2010) T Kobayashi et al.   LEUKEMIA

Inhibition of dextran sulfate sodium (DSS)-induced intestinal inflammation via enhanced IL-10 and TGF-β production by galectin-9 homologues isolated from intestinal parasites

(2010) Joo-Young Kim et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Targeting Activating Transcription Factor 3 by Galectin-9 Induces Apoptosis and Overcomes Various Types of Treatment Resistance in Chronic Myelogenous Leukemia

(2010) J. Kuroda et al.   MOLECULAR CANCER RESEARCH

The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity

(2010) Yurong Li et al.   MOLECULAR IMMUNOLOGY

A Crucial Role for Kupffer Cell-Derived Galectin-9 in Regulation of T Cell Immunity in Hepatitis C Infection

(2010) John A. Mengshol et al.   PLoS One

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-9 trafficking regulates apical-basal polarity in Madin–Darby canine kidney epithelial cells

(2010) Rashmi Mishra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selectins promote tumor metastasis

(2010) Heinz Läubli et al.   SEMINARS IN CANCER BIOLOGY

Galectin-9/TIM-3 Interaction Regulates Virus-Specific Primary and Memory CD8+ T Cell Response

(2010) Sharvan Sehrawat et al.   PLoS Pathogens

Galectin-9 ameliorates immune complex-induced arthritis by regulating FcγR expression on macrophages

(2009) Tomohiro Arikawa et al.   CLINICAL IMMUNOLOGY

Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions: A potent therapeutic tool for Th1- and/or Th17-mediated skin inflammation

(2009) Haruna Niwa et al.   CLINICAL IMMUNOLOGY

Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice

(2009) Feng-Cheng Chou et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Galectin-9 expands immunosuppressive macrophages to ameliorate T-cell-mediated lung inflammation

(2009) Tomohiro Arikawa et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intracellular galectin-9 activates inflammatory cytokines in monocytes

(2009) Ai Matsuura et al.   GENES TO CELLS

Th17 cytokines and their emerging roles in inflammation and autoimmunity

(2009) Lynette A. Fouser et al.   IMMUNOLOGICAL REVIEWS

Galectin-9 in Allergic Airway Inflammation and Hyper-Responsiveness in Mice

(2009) Erna Sziksz et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Galectin-9 Is a High Affinity IgE-binding Lectin with Anti-allergic Effect by Blocking IgE-Antigen Complex Formation

(2009) Toshiro Niki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Galectins in Protein Trafficking

(2009) Delphine Delacour et al.   TRAFFIC

Galectin-9 Significantly Prolongs the Survival of Fully Mismatched Cardiac Allografts in Mice

(2009) Wentao He et al.   TRANSPLANTATION

Anti-Inflammatory Actions of Intravenous Immunoglobulin

(2008) Falk Nimmerjahn et al.   Annual Review of Immunology

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

(2008) J. Klibi et al.   BLOOD

Retracted: A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells

(2008) Shoko Makishi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Co-localization of galectin-1 with GM1 ganglioside in the course of its clathrin- and raft-dependent endocytosis

(2008) R. Fajka-Boja et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

(2008) Masako Seki et al.   CLINICAL IMMUNOLOGY

Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice

(2008) Atsuya Nobumoto et al.   CLINICAL IMMUNOLOGY

Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices

(2008) A. Nobumoto et al.   GLYCOBIOLOGY

Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes

(2008) Bettina Brandt et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Tim-3-Galectin-9 pathway involves the suppression induced by CD4+CD25+ regulatory T cells

(2008) Feng Wang et al.   IMMUNOBIOLOGY

Detection of the Tim-3 ligand, galectin-9, inside the allograft during a rejection episode

(2008) Erika Lamkowski Naka et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of Th1 and Th17 cells in organ-specific autoimmunity

(2008) Valérie Dardalhon et al.   JOURNAL OF AUTOIMMUNITY

Structural Features of Galectin-9 and Galectin-1 That Determine Distinct T Cell Death Pathways

(2008) Shuguang Bi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-9 expression links to malignant potential of cervical squamous cell carcinoma

(2008) Meiyan Liang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Endogenous Galectin-3 Is Localized in Membrane Lipid Rafts and Regulates Migration of Dendritic Cells

(2008) Daniel K. Hsu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Different roles of galectin-9 isoforms in modulating E-selectin expression and adhesion function in LoVo colon carcinoma cells

(2008) Feng Zhang et al.   MOLECULAR BIOLOGY REPORTS

Activation of Tim-3–Galectin-9 pathway improves survival of fully allogeneic skin grafts

(2008) Feng Wang et al.   TRANSPLANT IMMUNOLOGY

Structural Analysis of the Human Galectin-9 N-terminal Carbohydrate Recognition Domain Reveals Unexpected Properties that Differ from the Mouse Orthologue

(2007) Masamichi Nagae et al.   JOURNAL OF MOLECULAR BIOLOGY