Synergistic MicroRNA Therapy in Liver Fibrotic Rat Using MRI-Visible Nanocarrier Targeting Hepatic Stellate Cells

Facile synthesis of semi-library of low charge density cationic polyesters from poly(alkylene maleate)s for efficient local gene delivery

(2018) Huijie Yan et al.   BIOMATERIALS

Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development

(2018) Yun-Chieh Sung et al.   Theranostics

pH-Sensitive Nanocarrier-Mediated Codelivery of Simvastatin and Noggin siRNA for Synergistic Enhancement of Osteogenesis

(2018) Jinsheng Huang et al.   ACS Applied Materials & Interfaces

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

HOTAIR Epigenetically Modulates PTEN Expression via MicroRNA-29b: A Novel Mechanism in Regulation of Liver Fibrosis

(2017) Fujun Yu et al.   MOLECULAR THERAPY

Rationally Designed 2-in-1 Nanoparticles Can Overcome Adaptive Resistance in Cancer

(2016) Aaron Goldman et al.   ACS Nano

Suppressive effect of microRNA-29b on hepatic stellate cell activation and its crosstalk with TGF-β1/Smad3

(2016) Chunli Liang et al.   CELL BIOCHEMISTRY AND FUNCTION

Non-viral nucleic acid containing nanoparticles as cancer therapeutics

(2016) Kristen L. Kozielski et al.   Expert Opinion on Drug Delivery

Theranostical nanosystem-mediated identification of an oncogene and highly effective therapy in hepatocellular carcinoma

(2016) Yu Guo et al.   HEPATOLOGY

MicroRNAs in hepatic pathophysiology

(2016) Yoshiki Murakami et al.   HEPATOLOGY RESEARCH

A combined microRNA-based targeted therapeutic approach to eradicate glioblastoma stem-like cells

(2016) Carla L. Esposito et al.   JOURNAL OF CONTROLLED RELEASE

Tumor-penetrating peptide modified and pH-sensitive polyplexes for tumor targeted siRNA delivery

(2016) Guoyong Zhou et al.   Polymer Chemistry

Inhibition of hIAPP Amyloid Aggregation and Pancreatic β-Cell Toxicity by OH-Terminated PAMAM Dendrimer

(2016) Esteban N. Gurzov et al.   Small

MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression

(2016) Jeongeun Hyun et al.   Nature Communications

MiR-125b is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis

(2015) Varun Nagpal et al.   CIRCULATION

Hepatic inflammation and fibrosis: Functional links and key pathways

(2015) Ekihiro Seki et al.   HEPATOLOGY

Hepatic fibrosis: Concept to treatment

(2015) Christian Trautwein et al.   JOURNAL OF HEPATOLOGY

MicroRNA regulatory networks in human adipose tissue and obesity

(2015) Peter Arner et al.   Nature Reviews Endocrinology

Antifibrotic Therapies in the Liver

(2015) D. Schuppan et al.   SEMINARS IN LIVER DISEASE

The Use of Nanoparticles to Deliver Nitric Oxide to Hepatic Stellate Cells for Treating Liver Fibrosis and Portal Hypertension

(2015) Hien T. T. Duong et al.   Small

Effective siRNA therapy of hepatoma mediated by a nonviral vector with MRI-visibility and biodegradability

(2015) Jin Wang et al.   RSC Advances

Drug and gene co-delivery systems for cancer treatment

(2015) Zhe Yang et al.   Biomaterials Science

A Reduction and pH Dual-Sensitive Polymeric Vector for Long-Circulating and Tumor-Targeted siRNA Delivery

(2014) Jingguo Li et al.   ADVANCED MATERIALS

Early to Phase II drugs currently under investigation for the treatment of liver fibrosis

(2014) Peter Hauff et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Novel role of nuclear receptor rev-erbα in hepatic stellate cell activation: Potential therapeutic target for liver injury

(2014) Ting Li et al.   HEPATOLOGY

miR-29b as a Therapeutic Agent for Angiotensin II-induced Cardiac Fibrosis by Targeting TGF-β/Smad3 signaling

(2014) Yang Zhang et al.   MOLECULAR THERAPY

Epigenetic Regulation ofmiR-17∼92Contributes to the Pathogenesis of Pulmonary Fibrosis

(2013) Duaa Dakhlallah et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MicroRNA-29 family, a crucial therapeutic target for fibrosis diseases

(2013) Yong He et al.   BIOCHIMIE

The Autoregulatory Feedback Loop of MicroRNA-21/Programmed Cell Death Protein 4/Activation Protein-1 (MiR-21/PDCD4/AP-1) as a Driving Force for Hepatic Fibrosis Development

(2013) Zhengping Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolving therapies for liver fibrosis

(2013) Detlef Schuppan et al.   JOURNAL OF CLINICAL INVESTIGATION

Copolymer of poly(ethylene glycol) and poly(l-lysine) grafting polyethylenimine through a reducible disulfide linkage for siRNA delivery

(2013) Jingguo Li et al.   Nanoscale

MicroRNAs in liver disease

(2013) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Dissection of Protein Interactomics Highlights MicroRNA Synergy

(2013) Wenliang Zhu et al.   PLoS One

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis

(2012) Tomohiro Ogawa et al.   GUT

miR-133a mediates TGF-β-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis

(2012) Christoph Roderburg et al.   JOURNAL OF HEPATOLOGY

miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression

(2012) Jiang Li et al.   JOURNAL OF HEPATOLOGY

Simultaneous Delivery of siRNA and Paclitaxel via a “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression

(2011) Tian-Meng Sun et al.   ACS Nano

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat

(2011) Du Cheng et al.   BIOMATERIALS

The specificities of small molecule inhibitors of the TGFß and BMP pathways

(2011) Janis Vogt et al.   CELLULAR SIGNALLING

The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice

(2011) Yong-Han Paik et al.   HEPATOLOGY

Effects of interferon-gamma liposomes targeted to platelet-derived growth factor receptor–beta on hepatic fibrosis in rats

(2011) Feng Li et al.   JOURNAL OF CONTROLLED RELEASE

Suppression of microRNA-29 Expression by TGF- 1 Promotes Collagen Expression and Renal Fibrosis

(2011) B. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

(2010) Christoph Roderburg et al.   HEPATOLOGY

Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats

(2010) Cheng Liu et al.   LABORATORY INVESTIGATION

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

The current state of serum biomarkers of hepatotoxicity

(2007) Josef Ozer et al.   TOXICOLOGY