AFM Imaging Reveals Multiple Conformational States of ADAMTS13

An open conformation of ADAMTS-13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura

(2018) E. Roose et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A model for the conformational activation of the structurally quiescent metalloprotease ADAMTS13 by von Willebrand factor

(2017) Kieron South et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAMTS-13 and von Willebrand factor: a dynamic duo

(2017) K. South et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics

(2017) M. Saha et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Reduced ADAMTS-13 level negatively correlates with inflammation factors in plasma of acute myeloid leukemia patients

(2017) Chen Liu et al.   LEUKEMIA RESEARCH

The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy

(2017) Felice Gragnano et al.   MEDIATORS OF INFLAMMATION

Accurate nanoscale flexibility measurement of DNA and DNA–protein complexes by atomic force microscopy in liquid

(2017) Divakaran Murugesapillai et al.   Nanoscale

Von Willebrand factor, ADAMTS13, and coronary microvascular obstruction: beautiful hypotheses, ugly facts

(2016) Raffaele De Caterina et al.   CARDIOVASCULAR RESEARCH

ADAMTS13: more than a regulator of thrombosis

(2016) Yun Feng et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Conformational quiescence of ADAMTS-13 prevents proteolytic promiscuity

(2016) K. South et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Preclinical assessment of a new recombinant ADAMTS-13 drug product (BAX930) for the treatment of thrombotic thrombocytopenic purpura

(2016) A. Kopić et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA–DNA pairing

(2016) Jiangguo Lin et al.   NUCLEIC ACIDS RESEARCH

Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic

(2016) Jorine M. Eeftens et al.   Cell Reports

Enhanced electrostatic force microscopy reveals higher-order DNA looping mediated by the telomeric protein TRF2

(2016) Parminder Kaur et al.   Scientific Reports

Shear-Dependent Interactions of von Willebrand Factor with Factor VIII and Protease ADAMTS 13 Demonstrated at a Single Molecule Level by Atomic Force Microscopy

(2015) Klaus Bonazza et al.   ANALYTICAL CHEMISTRY

ADAMTS13, lucky to have a hydrophobic pocket

(2015) X. L. Zheng   BLOOD

Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models

(2015) B. Pickens et al.   BLOOD

Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13

(2015) L. Deforche et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Allosteric activation of ADAMTS13 by von Willebrand factor

(2014) Joshua Muia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational activation of ADAMTS13

(2014) Kieron South et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An optimized fluorogenic ADAMTS13 assay with increased sensitivity for the investigation of patients with thrombotic thrombocytopenic purpura

(2013) J. Muia et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structure-function and regulation of ADAMTS-13 protease

(2013) X. L. Zheng   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres

(2013) Jiangguo Lin et al.   NUCLEIC ACIDS RESEARCH

Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

(2012) C. Jian et al.   BLOOD

Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13

(2009) T. Wu et al.   BLOOD

Mechanistic Studies on ADAMTS13 Catalysis

(2008) Enrico Di Stasio et al.   BIOPHYSICAL JOURNAL

In-Situ Atomic Force Microscopy (AFM) Imaging: Influence of AFM Probe Geometry on Diffusion to Microscopic Surfaces

(2008) David P. Burt et al.   LANGMUIR