Aptamer Chimeras for Therapeutic Delivery: The Challenging Perspectives

Aptamers: Uptake mechanisms and intracellular applications

(2018) Sorah Yoon et al.   ADVANCED DRUG DELIVERY REVIEWS

A DNA Nanotube-Peptide Biocomplex for mRNA Detection and Its Application in Cancer Diagnosis and Targeted Therapy

(2018) Xiaoting Ji et al.   CHEMISTRY-A EUROPEAN JOURNAL

Targeted delivery of melittin to cancer cells by AS1411 anti-nucleolin aptamer

(2018) Seyed Hossein Rajabnejad et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Aptamer-guided siRNA-loaded nanomedicines for systemic gene silencing in CD-44 expressing murine triple-negative breast cancer model

(2018) Walhan Alshaer et al.   JOURNAL OF CONTROLLED RELEASE

TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models

(2018) Gerónimo Fernández et al.   MOLECULAR THERAPY

MUC1 aptamer-targeted DNA micelles for dual tumor therapy using doxorubicin and KLA peptide

(2018) Fahimeh Charbgoo et al.   Nanomedicine-Nanotechnology Biology and Medicine

An anti-PDGFRβ aptamer for selective delivery of small therapeutic peptide to cardiac cells

(2018) Alessandra Romanelli et al.   PLoS One

Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines

(2018) David Porciani et al.   Nature Communications

Receptor-targeted aptamer-siRNA conjugate-directed transcriptional regulation of HIV-1

(2018) Jiehua Zhou et al.   Theranostics

STAT3 Gene Silencing by Aptamer-siRNA Chimera as Selective Therapeutic for Glioblastoma

(2018) Carla Lucia Esposito et al.   Molecular Therapy-Nucleic Acids

Targeting EGFR/HER2/HER3 with a Three-in-One Aptamer-siRNA Chimera Confers Superior Activity against HER2 + Breast Cancer

(2018) Xiaolin Yu et al.   Molecular Therapy-Nucleic Acids

Current Advances in Aptamers for Cancer Diagnosis and Therapy

(2018) Shin-ichiro Hori et al.   Cancers

In Vivo Use of a Multi-DNA Aptamer-Based Payload/Targeting System To Study Dopamine Dysregulation in the Central Nervous System

(2018) Erin M. McConnell et al.   ACS Chemical Neuroscience

Synergistic targeting HER2 and EGFR with a bivalent aptamer-siRNA chimera efficiently inhibits HER2-positive tumor growth

(2018) LU XUE et al.   MOLECULAR PHARMACEUTICS

Aptamer-miR-34c conjugate affects cell proliferation of non-small cell lung cancer cells

(2018) Valentina Russo et al.   Molecular Therapy-Nucleic Acids

Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

(2017) Shuaijian Ni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell-penetrating peptides (CPPs): From delivery of nucleic acids and antigens to transduction of engineered nucleases for application in transgenesis

(2017) Gandhi Rádis-Baptista et al.   JOURNAL OF BIOTECHNOLOGY

Precise glioblastoma targeting by AS1411 aptamer-functionalized poly ( l -γ-glutamylglutamine)–paclitaxel nanoconjugates

(2017) Zimiao Luo et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

A novel chemotherapy drug-free delivery system composed of three therapeutic aptamers for the treatment of prostate and breast cancers in vitro and in vivo

(2017) Khalil Abnous et al.   Nanomedicine-Nanotechnology Biology and Medicine

Incorporation of aptamers in the terminal loop of shRNAs yields an effective and novel combinatorial targeting strategy

(2017) Ka Ming Pang et al.   NUCLEIC ACIDS RESEARCH

Assembly of CRISPR ribonucleoproteins with biotinylated oligonucleotides via an RNA aptamer for precise gene editing

(2017) Jared Carlson-Stevermer et al.   Nature Communications

Simultaneous targeting of CD44 and EpCAM with a bispecific aptamer effectively inhibits intraperitoneal ovarian cancer growth

(2017) Jingying Zheng et al.   Theranostics

siRNA Delivery Strategies: A Comprehensive Review of Recent Developments

(2017) Katyayani Tatiparti et al.   Nanomaterials

Method for Dual Viral Vector Mediated CRISPR-Cas9 Gene Disruption in Primary Human Endothelial Cells

(2017) Haixia Gong et al.   Scientific Reports

Peptidomimetic Targeting of Cavβ2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac FunctionClinical Perspective

(2016) Francesca Rusconi et al.   CIRCULATION

Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer

(2016) Nancy J. Ganson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Delivery methods for site-specific nucleases: Achieving the full potential of therapeutic gene editing

(2016) Jia Liu et al.   JOURNAL OF CONTROLLED RELEASE

A combined microRNA-based targeted therapeutic approach to eradicate glioblastoma stem-like cells

(2016) Carla L. Esposito et al.   JOURNAL OF CONTROLLED RELEASE

An aptamer-antibody complex (oligobody) as a novel delivery platform for targeted cancer therapies

(2016) Kyun Heo et al.   JOURNAL OF CONTROLLED RELEASE

Multivalent Aptamer-RNA Conjugates for Simple and Efficient Delivery of Doxorubicin/siRNA into Multidrug-Resistant Cells

(2016) Hyosook Jeong et al.   MACROMOLECULAR BIOSCIENCE

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

(2016) Keiichiro Suzuki et al.   NATURE

CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

(2016) Daniel P. Dever et al.   NATURE

A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

(2016) Yang Yang et al.   NATURE BIOTECHNOLOGY

Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells

(2016) M. A. DeWitt et al.   Science Translational Medicine

Viral Vectors: The Road to Reducing Genotoxicity

(2016) Rhiannon M. David et al.   TOXICOLOGICAL SCIENCES

Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system

(2016) Taek-Chin Cheong et al.   Nature Communications

Targeted delivery of CRISPR/Cas9 to prostate cancer by modified gRNA using a flexible aptamer-cationic liposome

(2016) Shuai Zhen et al.   Oncotarget

Co-targeting EGFR and survivin with a bivalent aptamer-dual siRNA chimera effectively suppresses prostate cancer

(2016) Hong Yan Liu et al.   Scientific Reports

A New Transferrin Receptor Aptamer Inhibits New World Hemorrhagic Fever Mammarenavirus Entry

(2016) Keith E Maier et al.   Molecular Therapy-Nucleic Acids

Aptamer-miRNA-212 Conjugate Sensitizes NSCLC Cells to TRAIL

(2016) Margherita Iaboni et al.   Molecular Therapy-Nucleic Acids

Adenoviral vectors encoding CRISPR/Cas9 multiplexes rescue dystrophin synthesis in unselected populations of DMD muscle cells

(2016) Ignazio Maggio et al.   Scientific Reports

CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

(2015) Yubao Wang et al.   CELL

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

(2015) O. van Tellingen et al.   DRUG RESISTANCE UPDATES

SOD2 targeted gene editing by CRISPR/Cas9 yields Human cells devoid of MnSOD

(2015) Kimberly Cramer-Morales et al.   FREE RADICAL BIOLOGY AND MEDICINE

Challenges in CRISPR/CAS9 Delivery: Potential Roles of Nonviral Vectors

(2015) Ling Li et al.   HUMAN GENE THERAPY

Cancer immunotherapy via nucleic acid aptamers

(2015) Mostafa Khedri et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

High-throughput functional genomics using CRISPR–Cas9

(2015) Ophir Shalem et al.   NATURE REVIEWS GENETICS

Improved methods of AAV-mediated gene targeting for human cell lines using ribosome-skipping 2A peptide

(2015) Sivasundaram Karnan et al.   NUCLEIC ACIDS RESEARCH

The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation

(2015) Liang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superior Performance of Aptamer in Tumor Penetration over Antibody: Implication of Aptamer-Based Theranostics in Solid Tumors

(2015) Dongxi Xiang et al.   Theranostics

Pharmacokinetics of a Cholesterol-conjugated Aptamer Against the Hepatitis C Virus (HCV) NS5B Protein

(2015) Chang Ho Lee et al.   Molecular Therapy-Nucleic Acids

Modular Assembly of Cell-targeting Devices Based on an Uncommon G-quadruplex Aptamer

(2015) Felipe Opazo et al.   Molecular Therapy-Nucleic Acids

In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by CRISPR/Cas9

(2014) Shuai Zhen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CRISPR/Cas9-mediated genome engineering: An adeno-associated viral (AAV) vector toolbox

(2014) Elena Senís et al.   Biotechnology Journal

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Targeting Cdk11 in osteosarcoma cells using the CRISPR-cas9 system

(2014) Yong Feng et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Broccoli: Rapid Selection of an RNA Mimic of Green Fluorescent Protein by Fluorescence-Based Selection and Directed Evolution

(2014) Grigory S. Filonov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Adenoviral vector delivery of RNA-guided CRISPR/Cas9 nuclease complexes induces targeted mutagenesis in a diverse array of human cells

(2014) Ignazio Maggio et al.   Scientific Reports

Use of Oligonucleotide Aptamer Ligands to Modulate the Function of Immune Receptors

(2013) E. Gilboa et al.   CLINICAL CANCER RESEARCH

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

(2013) Hiroko Koike-Yusa et al.   NATURE BIOTECHNOLOGY

In vivo SELEX for Identification of Brain-penetrating Aptamers

(2013) Congsheng Cheng et al.   Molecular Therapy-Nucleic Acids

Direct Observation of Nanoparticle–Cancer Cell Nucleus Interactions

(2012) Duncan Hieu M. Dam et al.   ACS Nano

The Use of Therapeutic Peptides to Target and to Kill Cancer Cells

(2012) R. J. Boohaker et al.   CURRENT MEDICINAL CHEMISTRY

Functional In Vivo Delivery of Multiplexed Anti-HIV-1 siRNAs via a Chemically Synthesized Aptamer With a Sticky Bridge

(2012) Jiehua Zhou et al.   MOLECULAR THERAPY

Current Progress of RNA Aptamer-Based Therapeutics

(2012) Jiehua Zhou et al.   Frontiers in Genetics

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

Intra-Accumbens Injection of a Dopamine Aptamer Abates MK-801-Induced Cognitive Dysfunction in a Model of Schizophrenia

(2011) Matthew R. Holahan et al.   PLoS One

RNA Mimics of Green Fluorescent Protein

(2011) J. S. Paige et al.   SCIENCE

An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice

(2011) C. P. Neff et al.   Science Translational Medicine

Lipophilicity in drug discovery

(2010) Michael J Waring   Expert Opinion on Drug Discovery

Cardiomyocyte PDGFR-β signaling is an essential component of the mouse cardiac response to load-induced stress

(2010) Vishnu Chintalgattu et al.   JOURNAL OF CLINICAL INVESTIGATION

Expanding the Chemistry of DNA for in Vitro Selection

(2010) Jonathan D. Vaught et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting cancer cells with nucleic acid aptamers

(2010) Laura Cerchia et al.   TRENDS IN BIOTECHNOLOGY

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

(2009) Paula J. Bates et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

A Hybrid DNA Aptamer-Dendrimer Nanomaterial for Targeted Cell Labeling

(2009) Jing Zhou et al.   MACROMOLECULAR BIOSCIENCE

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

(2009) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH

Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy

(2008) Jiehua Zhou et al.   MOLECULAR THERAPY

Progress in Drug Delivery to the Central Nervous System by the Prodrug Approach

(2008) Barbara Pavan et al.   MOLECULES

Toll-Like Receptor 4 Is Involved in Subacute Stress–Induced Neuroinflammation and in the Worsening of Experimental Stroke

(2008) Javier R. Caso et al.   STROKE