Systems Pharmacology Dissection of Multi-Scale Mechanisms of Action of Huo-Xiang-Zheng-Qi Formula for the Treatment of Gastrointestinal Diseases

The phosphoinositide 3-kinase (PI3K) pathway and glycogen synthase kinase-3 (GSK-3) positively regulate the activity of metal-responsive transcription factor-1 (MTF-1) in response to zinc ions.

(2018) Yannick Andéol et al.   Biochemistry and Cell Biology

Betweenness centrality of intracranial electroencephalography networks and surgical epilepsy outcome

(2018) Bartosz T. Grobelny et al.   CLINICAL NEUROPHYSIOLOGY

The JAK2/STAT3 pathway is involved in the anti-melanoma effects of atractylenolide I

(2018) Xiu-Qiong Fu et al.   EXPERIMENTAL DERMATOLOGY

Jak-Stat pathway induces Drosophila follicle elongation by a gradient of apical contractility

(2018) Hervé Alégot et al.   eLife

Atractylenolide I stimulates intestinal epithelial repair through polyamine-mediated Ca 2+ signaling pathway

(2017) Hou-Pan Song et al.   PHYTOMEDICINE

A Methodology for Cancer Therapeutics by Systems Pharmacology-Based Analysis: A Case Study on Breast Cancer-Related Traditional Chinese Medicines

(2017) Yan Li et al.   PLoS One

A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula

(2017) Jinghui Wang et al.   Scientific Reports

Systematic understanding the mechanisms of vitiligo pathogenesis and its treatment by Qubaibabuqi formula

(2016) Tianli Pei et al.   JOURNAL OF ETHNOPHARMACOLOGY

Structural insights into the polypharmacological activity of quercetin on serine/threonine kinases

(2016) Ranjit Vijayan et al.   Drug Design Development and Therapy

Preparation of nobiletin in self-microemulsifying systems and its intestinal permeability in rats

(2016) Jing Yao et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM

(2015) Yonghua Wang et al.   Evidence-based Complementary and Alternative Medicine

Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States

(2015) Anne F. Peery et al.   GASTROENTEROLOGY

Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae

(2015) Jingxiao Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula

(2015) Yan Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis

(2015) Yan Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function

(2015) Yongjian Xiong et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Functional Dyspepsia

(2015) Nicholas J. Talley et al.   NEW ENGLAND JOURNAL OF MEDICINE

The protective effect of atractylenolide I on systemic inflammation in the mouse model of sepsis created by cecal ligation and puncture

(2015) Aimin Wang et al.   PHARMACEUTICAL BIOLOGY

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

K+ channels as potential targets for the treatment of gastrointestinal motor disorders

(2014) Diego Currò   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-inflammatory Effects of Cavidine In Vitro and In Vivo, a Selective COX-2 Inhibitor in LPS-Induced Peritoneal Macrophages of Mouse

(2014) Xiaofeng Niu et al.   INFLAMMATION

Selective Antibacterial Activity of Patchouli Alcohol AgainstHelicobacter pyloriBased on Inhibition of Urease

(2014) Xiao-Dan Yu et al.   PHYTOTHERAPY RESEARCH

Genkwanin Inhibits Proinflammatory Mediators Mainly through the Regulation of miR-101/MKP-1/MAPK Pathway in LPS-Activated Macrophages

(2014) Yuan Gao et al.   PLoS One

GSK3β and the control of infectious bacterial diseases

(2014) Huizhi Wang et al.   TRENDS IN MICROBIOLOGY

Identifying roles of “Jun-Chen-Zuo-Shi” component herbs of QiShenYiQi formula in treating acute myocardial ischemia by network pharmacology

(2014) Leihong Wu et al.   Chinese Medicine

An Integrative Platform of TCM Network Pharmacology and Its Application on a Herbal Formula,Qing-Luo-Yin

(2013) Bo Zhang et al.   Evidence-based Complementary and Alternative Medicine

Systems approaches and polypharmacology for drug discovery from herbal medicines: An example using licorice

(2013) Hui Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Investigation into the mechanism of Eucommia ulmoides Oliv. based on a systems pharmacology approach

(2013) Yan Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antioxidant and anti-acetylcholinesterase activity of commercially available medicinal infusions after in vitro gastrointestinal digestion

(2013) Maria L. M. Serralheiro et al.   Journal of Medicinal Plants Research

Autophagy: a new target or an old strategy for the treatment of Crohn's disease?

(2013) Kris Nys et al.   Nature Reviews Gastroenterology & Hepatology

Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease

(2013) Mehmet Coskun et al.   PHARMACOLOGICAL RESEARCH

Immunomodulatory Potential of Patchouli Alcohol Isolated from Pogostemon cablin (Blanco) Benth (Lamiaceae) in Mice

(2013) JB Liao et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

Polyamines regulate intestinal epithelial restitution through TRPC1-mediated Ca2+ signaling by differentially modulating STIM1 and STIM2

(2012) Jaladanki N. Rao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Chinese Herbal Medicine Liu Jun Zi Tang and Xiang Sha Liu Jun Zi Tang for Functional Dyspepsia: Meta-Analysis of Randomized Controlled Trials

(2012) Ya Xiao et al.   Evidence-based Complementary and Alternative Medicine

Liquorice reduced cyclosporine bioavailability by activating P-glycoprotein and CYP 3A

(2012) Yu-Chi Hou et al.   FOOD CHEMISTRY

A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment

(2012) Xiuxiu Li et al.   PLoS One

Dopamine D1 receptors mediate dopamine-induced duodenal epithelial ion transport in rats

(2012) Xiao-Yan Feng et al.   Translational Research

Inhibition of Pim1 Kinase Activation Attenuates Allergen-Induced Airway Hyperresponsiveness and Inflammation

(2011) Yoo Seob Shin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Anti-inflammatory activity of patchouli alcohol isolated from Pogostemonis Herba in animal models

(2011) Yu-Cui Li et al.   FITOTERAPIA

Bioactive polar compounds from stem bark of Magnolia officinalis

(2011) Sheng-xian Yu et al.   FITOTERAPIA

Oral administration of patchouli alcohol isolated from Pogostemonis Herba augments protection against influenza viral infection in mice

(2011) Yu-Cui Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Recent advances in the transcriptional regulation of the flavonoid biosynthetic pathway

(2011) Imène Hichri et al.   JOURNAL OF EXPERIMENTAL BOTANY

Glycogen synthase kinase 3: A point of convergence for the host inflammatory response

(2010) Huizhi Wang et al.   CYTOKINE

Anti-apoptotic PI3K/Akt signaling by sodium/glucose transporter 1 reduces epithelial barrier damage and bacterial translocation in intestinal ischemia

(2010) Ching-Ying Huang et al.   LABORATORY INVESTIGATION

Sparse Partial Least Squares Classification for High Dimensional Data

(2010) Dongjun Chung et al.   Statistical Applications in Genetics and Molecular Biology

Simultaneous characterization and quantitation of 11 coumarins in Radix Angelicae Dahuricae by high performance liquid chromatography with electrospray tandem mass spectrometry

(2009) Xuguang Zheng et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Protective effects of neohesperidin and poncirin isolated from the fruits ofPoncirus trifoliataon potential gastric disease

(2009) Je-Hyuk Lee et al.   PHYTOTHERAPY RESEARCH

Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica

(2008) Jeong Mi Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Beneficial or harmful influence of phytosterols on human cells?

(2008) Blazej Rubis et al.   BRITISH JOURNAL OF NUTRITION

Influence of sources and doses of N and K on herbage, oil yield and nutrient uptake of patchouli [Pogostemon cablin (Blanco) Benth.] in semi-arid tropics

(2008) Munnu Singh et al.   INDUSTRIAL CROPS AND PRODUCTS

Helicobacter pyloriVacA-induced Inhibition of GSK3 through the PI3K/Akt Signaling Pathway

(2008) Masaaki Nakayama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLC bioautography-guided isolation of antioxidants from fruit of Perilla frutescens var. acuta

(2008) Lihua Gu et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Targeting phosphoinositide 3-kinase—Moving towards therapy

(2007) Romina Marone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect

(2007) Kyoung Ah Kang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents

(2007) Qun Xu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY