Journal
FITOTERAPIA
Volume 83, Issue 2, Pages 356-361Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2011.11.020
Keywords
Magnolia officinalis; Hydrophilic compounds; Anti-spasmodic; Antioxidant activity
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Funding
- National Natural Science Foundation of China [81073042]
- National Bureau of Traditional Chinese Medicine [200807020]
- China Academy of Chinese Medical Sciences [ZZ20090108]
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Two new phenylethanoid glycosides magnoloside D (1) and E (2), together with nine known compounds, were isolated from the polar part of methanol extract of the stem bark of Magnolia officinalis. The structures of the new compounds were established on the basis of spectral analysis. Anti-spasmodic activity of four major constituents (3, 4, 9 and 11) was tested in isolated colon of rat, compounds 3, 4, and 9 showed inhibition against acetylcholine, with the effect similar to that of magnolol and honokiol. At the same time, antioxidant activity of the isolated compounds was investigated using a DPPH and an ORAC assay. All of the compounds, except compound 8 showed potent antioxidant capacity in the ORAC assay, while compounds 1-5 and 11 exhibited potent antioxidant activity in the DPPH assay. (C) 2011 Elsevier B.V. All rights reserved.
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