High Glucose-Induced Oxidative Stress Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances Possibly via p38 MAPK Activation in Rat Nucleus Pulposus Cells

Hypoxia potentiates the BMP-2 driven COL2A1 stimulation in human articular chondrocytes via p38 MAPK

(2016) J.E. Lafont et al.   OSTEOARTHRITIS AND CARTILAGE

Interference with the contractile machinery of the fibroblastic chondrocyte cytoskeleton induces re-expression of the cartilage phenotype through involvement of PI3K, PKC and MAPKs

(2013) Markus Rottmar et al.   EXPERIMENTAL CELL RESEARCH

P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture

(2013) Derek H. Rosenzweig et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration

(2013) Luigi A. Nasto et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration

(2012) Takashi Yurube et al.   ARTHRITIS RESEARCH & THERAPY

Effect of hyperglycemia on apoptosis of notochordal cells and intervertebral disc degeneration in diabetic rats

(2011) Ho-Yeon Won et al.   JOURNAL OF NEUROSURGERY-SPINE

Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration

(2011) W Erwin et al.   ARTHRITIS RESEARCH & THERAPY

Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression

(2010) Akihiko Hiyama et al.   ARTHRITIS AND RHEUMATISM

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Dominant-negative p38α mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus

(2009) Rajarajan A. Thandavarayan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells

(2009) Ravi P. Sahu et al.   CARCINOGENESIS

PCI-24781 Induces Caspase and Reactive Oxygen Species-Dependent Apoptosis Through NF- B Mechanisms and Is Synergistic with Bortezomib in Lymphoma Cells

(2009) S. Bhalla et al.   CLINICAL CANCER RESEARCH

High osmolality activates the G1 and G2 cell cycle checkpoints and affects the DNA integrity of nucleus pulposus intervertebral disc cells triggering an enhanced DNA repair response

(2009) Eleni Mavrogonatou et al.   DNA REPAIR

IGF-1 rescues human intervertebral annulus cells fromin vitrostress-induced premature senescence

(2008) Helen E. Gruber et al.   GROWTH FACTORS

p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1

(2008) Rebecca K. Studer et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration

(2008) Sarah Heathfield et al.   ARTHRITIS RESEARCH & THERAPY

Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes

(2007) Clara L. Sampieri et al.   MATRIX BIOLOGY