Recent Update on the Pharmacological Effects and Mechanisms of Dihydromyricetin

Dihydromyricetin Ameliorates Nonalcoholic Fatty Liver Disease by Improving Mitochondrial Respiratory Capacity and Redox Homeostasis Through Modulation of SIRT3 Signaling

(2018) Xianglong Zeng et al.   ANTIOXIDANTS & REDOX SIGNALING

Dihydromyricetin sensitizes human acute myeloid leukemia cells to retinoic acid-induced myeloid differentiation by activating STAT1

(2018) Ming-hui He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dihydromyricetin ameliorates foam cell formation via LXRα-ABCA1/ABCG1-dependent cholesterol efflux in macrophages

(2018) Yi Zeng et al.   BIOMEDICINE & PHARMACOTHERAPY

Polyphenols and Bioavailability: an update

(2018) Hui Teng et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Salusin-α attenuates hepatic steatosis and atherosclerosis in high fat diet-fed low density lipoprotein receptor deficient mice

(2018) Kun Tang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rosuvastatin improves myocardial hypertrophy after hemodynamic pressure overload via regulating the crosstalk of Nrf2/ARE and TGF-β/ smads pathways in rat heart

(2018) Pengbo Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

RhoA/ROCK signaling regulates smooth muscle phenotypic modulation and vascular remodeling via the JNK pathway and vimentin cytoskeleton

(2018) Lian Tang et al.   PHARMACOLOGICAL RESEARCH

Blood Ammonia as a Possible Etiological Agent for Alzheimer’s Disease

(2018) Yan Jin et al.   Nutrients

Dihydromyricetin Attenuates Myocardial Hypertrophy Induced by Transverse Aortic Constriction via Oxidative Stress Inhibition and SIRT3 Pathway Enhancement

(2018) Yun Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Muscarinic receptor mediated signaling pathways in hepatocytes from CCL4 - induced liver fibrotic rat

(2017) Lin Luo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dihydromyricetin attenuated Ang II induced cardiac fibroblasts proliferation related to inhibitory of oxidative stress

(2017) Qiuyi Song et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A dual antibacterial mechanism involved in membrane disruption and DNA binding of 2R , 3R -dihydromyricetin from pine needles of Cedrus deodara against Staphylococcus aureus

(2017) Yanping Wu et al.   FOOD CHEMISTRY

Dihydromyricetin induces apoptosis and cytoprotective autophagy through ROS-NF-κB signalling in human melanoma cells

(2017) Ding-Zhou Zhou et al.   FREE RADICAL RESEARCH

Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-κB and JAK/STAT signaling pathways in rats

(2017) Lingling Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dihydromyricetin enhances glucose uptake by inhibition of MEK/ERK pathway and consequent down-regulation of phosphorylation of PPARγ in 3T3-L1 cells

(2017) Lei Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Anti-inflammatory effects of dihydromyricetin in a mouse model of asthma

(2017) Bin Xu et al.   Molecular Medicine Reports

Dihydromyricetin induces mitochondria-mediated apoptosis in HepG2 cells through down-regulation of the Akt/Bad pathway

(2017) Zhuangwei Zhang et al.   NUTRITION RESEARCH

Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation

(2017) Zhaoxiang Ren et al.   PSYCHOPHARMACOLOGY

Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury

(2017) Ping Qiu et al.   TOXICOLOGY LETTERS

Dihydromyricetin Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Mice

(2017) Bin Wu et al.   Biomed Research International

Protection of oxidative stress induced apoptosis in osteosarcoma cells by dihydromyricetin through down-regulation of caspase activation and up-regulation of BcL-2

(2017) Yuming Wang et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

ON or OFF?: Modulating the N-Methyl-D-Aspartate Receptor in Major Depression

(2017) Shi Yu Chan et al.   Frontiers in Molecular Neuroscience

Dihydromyricetin Protects against Bone Loss in Ovariectomized Mice by Suppressing Osteoclast Activity

(2017) Libo Zhao et al.   Frontiers in Pharmacology

Dihydromyricetin Induces Apoptosis and Reverses Drug Resistance in Ovarian Cancer Cells by p53-mediated Downregulation of Survivin

(2017) Yingqi Xu et al.   Scientific Reports

Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity

(2016) Zhao-xiang Ren et al.   ACTA PHARMACOLOGICA SINICA

The cardioprotective effect of dihydromyricetin prevents ischemia–reperfusion-induced apoptosis in vivo and in vitro via the PI3K/Akt and HIF-1α signaling pathways

(2016) Shasha Liu et al.   APOPTOSIS

Dihydromyricetin from Ampelopsis grossedentata inhibits melanogenesis through down-regulation of MAPK, PKA and PKC signaling pathways

(2016) Huey-Chun Huang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer

(2016) Shang-Jyh Kao et al.   ENVIRONMENTAL TOXICOLOGY

Preventive Effect of Dihydromyricetin against Cisplatin-Induced NephrotoxicityIn VitroandIn Vivo

(2016) Fei Wu et al.   Evidence-based Complementary and Alternative Medicine

Dihydromyricetin Ameliorates 3NP-induced Behavioral Deficits and Striatal Injury in Rats

(2016) Shuhua Mu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Apoptosis inhibition effect of Dihydromyricetin against UVA-exposed human keratinocyte cell line

(2016) Zhe He et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Dihydromyricetin suppresses TNF-α-induced NF-κB activation and target gene expression

(2016) Nina Tang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Protective Effects of Dihydromyricetin against •OH-Induced Mesenchymal Stem Cells Damage and Mechanistic Chemistry

(2016) Xican Li et al.   MOLECULES

Dihydromyricetin protects against liver ischemia/reperfusion induced apoptosis via activation of FOXO3a-mediated autophagy

(2016) Yongbiao Chen et al.   Oncotarget

Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway

(2016) Xianjuan Kou et al.   Oncotarget

Metabolomics reveals the protective of Dihydromyricetin on glucose homeostasis by enhancing insulin sensitivity

(2016) Liang Le et al.   Scientific Reports

Hydrogen Sulfide Regulates Krüppel‐Like Factor 5 Transcription Activity via Specificity Protein 1 S‐Sulfhydration at Cys664 to Prevent Myocardial Hypertrophy

(2016) Guoliang Meng et al.   Journal of the American Heart Association

Protective Effect of Dihydromyricetin Against Lipopolysaccharide-Induced Acute Kidney Injury in a Rat Model

(2016) Jun-Tao Wang et al.   MEDICAL SCIENCE MONITOR

Brain-derived neurotrophic factor increase during treatment in severe mental illness inpatients

(2016) G L Nuernberg et al.   Translational Psychiatry

Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells

(2015) F.J. Ji et al.   GENETICS AND MOLECULAR RESEARCH

Dihydromyricetin protects endothelial cells from hydrogen peroxide-induced oxidative stress damage by regulating mitochondrial pathways

(2015) Xiaolong Hou et al.   LIFE SCIENCES

Dihydromyricetin Improves Hypobaric Hypoxia-Induced Memory Impairment via Modulation of SIRT3 Signaling

(2015) Peng Liu et al.   MOLECULAR NEUROBIOLOGY

Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial

(2015) Shihui Chen et al.   PHARMACOLOGICAL RESEARCH

Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injuryviaJNK-dependent mechanism in mice

(2015) Jun Xie   WORLD JOURNAL OF GASTROENTEROLOGY

Dihydromyricetin prevents cardiotoxicity and enhances anticancer activity induced by adriamycin

(2015) Hong Zhu et al.   Oncotarget

Dihydromyricetin ameliorates the oxidative stress response induced by methylglyoxal via the AMPK/GLUT4 signaling pathway in PC12 cells

(2014) Baoping Jiang et al.   BRAIN RESEARCH BULLETIN

Biased β2-adrenoceptor signalling in heart failure: pathophysiology and drug discovery

(2014) Anthony Yiu-Ho Woo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dihydromyricetin Activates AMP-Activated Protein Kinase and P38MAPK Exerting Antitumor Potential in Osteosarcoma

(2014) Z. Zhao et al.   Cancer Prevention Research

Rescue of cardiac failing and remodelling by inhibition of protein phosphatase 1γis associated with suppression of the alternative splicing factor-mediated splicing of Ca2+/calmodulin-dependent protein kinase δ

(2014) Ru-Jia Liao et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mTOR and regulating its upstream pathways

(2014) Juan Xia et al.   FOOD AND CHEMICAL TOXICOLOGY

Dihydromyricetin induces mouse hepatoma Hepal-6 cell apoptosis via the transforming growth factor-β pathway

(2014) BIN LIU et al.   Molecular Medicine Reports

Antinociceptive and anti-inflammatory effects of flavonoids PMT1 and PMT2 isolated fromPiper montealegreanumYuncker (Piperaceae) in mice

(2014) Aline Cavalcanti de Queiroz et al.   NATURAL PRODUCT RESEARCH

Dihydromyricetin Prevents Fetal Alcohol Exposure-Induced Behavioral and Physiological Deficits: The Roles of GABAA Receptors in Adolescence

(2014) Jing Liang et al.   NEUROCHEMICAL RESEARCH

Dihydromyricetin induces cell cycle arrest and apoptosis in melanoma SK-MEL-28 cells

(2014) GUOFANG ZENG et al.   ONCOLOGY REPORTS

Attenuating effects of dihydromyricetin on angiotensin II-induced rat cardiomyocyte hypertrophy related to antioxidative activity in a NO-dependent manner

(2014) Guoliang Meng et al.   PHARMACEUTICAL BIOLOGY

Dihydromyricetin inhibits migration and invasion of hepatoma cells through regulation of MMP-9 expression

(2014) Qing-Yu Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Dihydromyricetin suppresses the proliferation of hepatocellular carcinoma cells by inducing G2/M arrest through the Chk1/Chk2/Cdc25C pathway

(2013) HAILI HUANG et al.   ONCOLOGY REPORTS

Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication

(2012) Y. Shen et al.   JOURNAL OF NEUROSCIENCE

Modulation of Anti-Oxidation Ability by Proanthocyanidins during Germination of Arabidopsis thaliana Seeds

(2011) Li-Guo Jia et al.   Molecular Plant