The cardioprotective effect of dihydromyricetin prevents ischemia–reperfusion-induced apoptosis in vivo and in vitro via the PI3K/Akt and HIF-1α signaling pathways

A cardiac myocyte-restricted Lin28/let-7 regulatory axis promotes hypoxia-mediated apoptosis by inducing the AKT signaling suppressor PIK3IP1

(2016) Shaurya Joshi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

iNOS Induces Vascular Endothelial Cell Migration and Apoptosis Via Autophagy in Ischemia/Reperfusion Injury

(2016) Tiebing Zhu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway

(2016) Ruxin Zhang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

MicroRNA-93 Downregulation Ameliorates Cerebral Ischemic Injury Through the Nrf2/HO-1 Defense Pathway

(2016) Peng Wang et al.   NEUROCHEMICAL RESEARCH

Auricular vagus nerve stimulation promotes functional recovery and enhances the post-ischemic angiogenic response in an ischemia/reperfusion rat model

(2016) Ying Jiang et al.   NEUROCHEMISTRY INTERNATIONAL

Protective Effect of Dihydromyricetin Against Lipopolysaccharide-Induced Acute Kidney Injury in a Rat Model

(2016) Jun-Tao Wang et al.   MEDICAL SCIENCE MONITOR

Sex differences in mechanisms, presentation and management of ischaemic heart disease

(2015) Filippo Crea et al.   ATHEROSCLEROSIS

Levosimendan inhibits interleukin-1β-induced apoptosis through activation of Akt and inhibition of inducible nitric oxide synthase in rat cardiac fibroblasts

(2015) Muneyoshi Okada et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives

(2015) Iris L. K. Wong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Suppression of Inflammatory Responses by Dihydromyricetin, a Flavonoid from Ampelopsis grossedentata, via Inhibiting the Activation of NF-κB and MAPK Signaling Pathways

(2015) X. L. Hou et al.   JOURNAL OF NATURAL PRODUCTS

Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway

(2015) Linying Shi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Glucagon-like peptide-1 protects cardiomyocytes from advanced oxidation protein product-induced apoptosis via the PI3K/Akt/Bad signaling pathway

(2015) HUA ZHANG et al.   Molecular Medicine Reports

Dihydromyricetin Improves Hypobaric Hypoxia-Induced Memory Impairment via Modulation of SIRT3 Signaling

(2015) Peng Liu et al.   MOLECULAR NEUROBIOLOGY

Targeting Myocardial Reperfusion Injury — The Search Continues

(2015) Derek J. Hausenloy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial

(2015) Shihui Chen et al.   PHARMACOLOGICAL RESEARCH

Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injuryviaJNK-dependent mechanism in mice

(2015) Jun Xie   WORLD JOURNAL OF GASTROENTEROLOGY

Ginsenoside Rb1 prevents hypoxia-reoxygenation-induced apoptosis in H9c2 cardiomyocytes via an estrogen receptor-dependent crosstalk among the Akt, JNK, and ERK 1/2 pathways using a label-free quantitative proteomics analysis

(2015) Qidi Ai et al.   RSC Advances

bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reperfusion via the activation of the PI3K/Akt/mTOR pathway

(2015) Zhou-Guang Wang et al.   Scientific Reports

Influence of socioeconomic factors on hospital readmissions for heart failure and acute myocardial infarction in patients 65 years and older: evidence from a systematic review

(2015) Gianfranco Damiani et al.   Clinical Interventions in Aging

Dihydromyricetin prevents cardiotoxicity and enhances anticancer activity induced by adriamycin

(2015) Hong Zhu et al.   Oncotarget

Dilong Prevents the High-KCl Cardioplegic Solution Administration-Induced Apoptosis in H9c2 Cardiomyoblast Cells Mediated by MEK

(2014) Chien-Kuo Han et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

The effects of escitalopram on myocardial apoptosis and the expression of Bax and Bcl-2 during myocardial ischemia/reperfusion in a model of rats with depression

(2014) Yiming Wang et al.   BMC Psychiatry

Neuroprotective effects of gallic acid against hypoxia/reoxygenation-induced mitochondrial dysfunctions in vitro and cerebral ischemia/reperfusion injury in vivo

(2014) Jing Sun et al.   BRAIN RESEARCH

Dihydromyricetin ameliorates the oxidative stress response induced by methylglyoxal via the AMPK/GLUT4 signaling pathway in PC12 cells

(2014) Baoping Jiang et al.   BRAIN RESEARCH BULLETIN

SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1α-dependent pathway

(2014) Jianmin Gu et al.   CARDIOVASCULAR RESEARCH

Acetylcholine Promotes ROS Detoxification Against Hypoxia/reoxygenation-Induced Oxidative Stress Through FoxO3a/PGC-1a Dependent Superoxide Dismutase

(2014) Lei Sun et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Notoginsenoside R1-mediated neuroprotection involves estrogen receptor-dependent crosstalk between Akt and ERK1/2 pathways: A novel mechanism of Nrf2/ARE signaling activation

(2014) X. Meng et al.   FREE RADICAL RESEARCH

Protective effect of vitexin compound B-1 against hypoxia/reoxygenation-induced injury in differentiated PC12 cells via NADPH oxidase inhibition

(2014) Zhong-Bao Yang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Attenuating effects of dihydromyricetin on angiotensin II-induced rat cardiomyocyte hypertrophy related to antioxidative activity in a NO-dependent manner

(2014) Guoliang Meng et al.   PHARMACEUTICAL BIOLOGY

Recrystallization of Dihydromyricetin from Ampelopsis grossedentata and Its Anti-Oxidant Activity Evaluation

(2014) Wenzhen Liao et al.   REJUVENATION RESEARCH

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

(2013) Krishnendu Sinha et al.   ARCHIVES OF TOXICOLOGY

C1q/Tumor Necrosis Factor-Related Protein-9, a Novel Adipocyte-Derived Cytokine, Attenuates Adverse Remodeling in the Ischemic Mouse Heart via Protein Kinase A Activation

(2013) Y. Sun et al.   CIRCULATION

Simultaneous Determination of Dihydromyricetin and Resveratrol in Ampelopsis sinica (Miq.) W.T. Wang by High-Performance Liquid Chromatography Coupled with a Diode Array Detection Method

(2013) M.-Y. Jin et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

FAT10 protects cardiac myocytes against apoptosis

(2013) Xiaogang Peng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia–reperfusion injury through suppression of apoptosis and inflammation

(2013) Shuai Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Midazolam provides cytoprotective effect during corticosterone-induced damages in rat astrocytes by stimulating steroidogenesis

(2013) Wen-Zhi Guo et al.   NEUROSCIENCE LETTERS

Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication

(2012) Y. Shen et al.   JOURNAL OF NEUROSCIENCE

PPAR-γ and AMPK – Advantageous targets for myocardial ischemia/reperfusion therapy

(2011) Alex Morrison et al.   BIOCHEMICAL PHARMACOLOGY

Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA

(2011) Zsolt Radak et al.   MOLECULAR ASPECTS OF MEDICINE

Amlodipine inhibits TNF-α production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway

(2009) Xiao-Qiang Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion

(2008) Dieter A. Kubli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY