Contribution of Altered Endocannabinoid System to Overactive mTORC1 Signaling in Focal Cortical Dysplasia

Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial

(2018) Elizabeth A Thiele et al.   LANCET

DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons

(2018) Philip H. Iffland et al.   NEUROBIOLOGY OF DISEASE

Review: The international consensus classification of Focal Cortical Dysplasia - a critical update 2018

(2018) I. M. Najm et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias

(2017) Alissa M. D’Gama et al.   Cell Reports

Rare genetic variants in the endocannabinoid system genes CNR1 and DAGLA are associated with neurological phenotypes in humans

(2017) Douglas R. Smith et al.   PLoS One

Loss of Cannabinoid CB1Receptors Induces Cortical Migration Malformations and Increases Seizure Susceptibility

(2016) Javier Díaz-Alonso et al.   CEREBRAL CORTEX

Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex

(2016) Evan J. Hess et al.   EPILEPSIA

Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial

(2016) Orrin Devinsky et al.   LANCET NEUROLOGY

Cannabinoid Control of Learning and Memory through HCN Channels

(2016) Mattia Maroso et al.   NEURON

Clinical and immunohistochemical characteristics of type II and type I focal cortical dysplasia

(2016) Kun Yao et al.   Oncotarget

Mutations in the mammalian target of rapamycin pathway regulatorsNPRL2andNPRL3cause focal epilepsy

(2015) Michael G. Ricos et al.   ANNALS OF NEUROLOGY

PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia

(2015) Laura A. Jansen et al.   BRAIN

PKA-Dependent Phosphorylation of Ribosomal Protein S6 Does Not Correlate with Translation Efficiency in Striatonigral and Striatopallidal Medium-Sized Spiny Neurons

(2015) A. Biever et al.   JOURNAL OF NEUROSCIENCE

Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy

(2015) Jae Seok Lim et al.   NATURE MEDICINE

Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy

(2015) Ivan Soltesz et al.   NATURE REVIEWS NEUROSCIENCE

Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB1receptors on developing cortical neurons

(2015) Adán de Salas-Quiroga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CB1Cannabinoid Receptor-Dependent Activation of mTORC1/Pax6 Signaling Drives Tbr2 Expression and Basal Progenitor Expansion in the Developing Mouse Cortex

(2014) Javier Díaz-Alonso et al.   CEREBRAL CORTEX

An organotypic brain slice preparation from adult patients with temporal lobe epilepsy

(2014) Emmanuel Eugène et al.   JOURNAL OF NEUROSCIENCE METHODS

Epilepsy Related to Developmental Tumors and Malformations of Cortical Development

(2014) Eleonora Aronica et al.   Neurotherapeutics

Targeting the endocannabinoid system in the treatment of fragile X syndrome

(2013) Arnau Busquets-Garcia et al.   NATURE MEDICINE

Abnormal maturation and differentiation of neocortical neurons in epileptogenic cortical malformation: Unique distribution of layer-specific marker cells of focal cortical dysplasia and hemimegalencephaly

(2012) Asako Arai et al.   BRAIN RESEARCH

The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis

(2012) J. Diaz-Alonso et al.   JOURNAL OF NEUROSCIENCE

In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis

(2011) K. Goffin et al.   BRAIN

Decreased hyperpolarization-activated currents in layer 5 pyramidal neurons enhances excitability in focal cortical dysplasia

(2011) Asher J. Albertson et al.   JOURNAL OF NEUROPHYSIOLOGY

Concerted Action of CB1 Cannabinoid Receptor and Deleted in Colorectal Cancer in Axon Guidance

(2011) A. Argaw et al.   JOURNAL OF NEUROSCIENCE

The application of cortical layer markers in the evaluation of cortical dysplasias in epilepsy

(2010) George Hadjivassiliou et al.   ACTA NEUROPATHOLOGICA

Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease

(2010) Cristina Blázquez et al.   BRAIN

The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1

(2010) Ingmar Blümcke et al.   EPILEPSIA

Early Progenitor Cell Marker Expression Distinguishes Type II From Type I Focal Cortical Dysplasias

(2010) Ksenia A. Orlova et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies

(2010) E. Zurolo et al.   NEUROSCIENCE

Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

(2009) Emma Puighermanal et al.   NATURE NEUROSCIENCE

SNP analysis to results (SNPator): a web-based environment oriented to statistical genomics analyses upon SNP data

(2008) C. Morcillo-Suarez et al.   BIOINFORMATICS

Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus

(2008) A. Ludanyi et al.   JOURNAL OF NEUROSCIENCE

Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning

(2008) J. Mulder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA