Rare genetic variants in the endocannabinoid system genes CNR1 and DAGLA are associated with neurological phenotypes in humans

Crystal structures of agonist-bound human cannabinoid receptor CB1

(2017) Tian Hua et al.   NATURE

Anxiety, Stress, and Fear Response in Mice With Reduced Endocannabinoid Levels

(2016) Imke Jenniches et al.   BIOLOGICAL PSYCHIATRY

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

The CB2 receptor and its role as a regulator of inflammation

(2016) Caroline Turcotte et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans

(2016) Whitney E. Melroy-Greif et al.   DRUG AND ALCOHOL DEPENDENCE

Important role of endocannabinoid signaling in the development of functional vision and locomotion in zebrafish

(2016) Andrea Martella et al.   FASEB JOURNAL

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

The endocannabinoid system and neuropathic pain

(2016) Rafael Maldonado et al.   PAIN

Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population

(2016) Danielle N. Rhyne et al.   PHARMACOTHERAPY

Endocannabinoid Signaling Regulates Sleep Stability

(2016) Matthew J. Pava et al.   PLoS One

Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders

(2016) Fabio Arturo Iannotti et al.   PROGRESS IN LIPID RESEARCH

Endocannabinoid system as a regulator of tumor cell malignancy – biological pathways and clinical significance

(2016) Maria Pyszniak et al.   OncoTargets and Therapy

Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures

(2016) Yuki Sugaya et al.   Cell Reports

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

(2015) Sue Richards et al.   GENETICS IN MEDICINE

Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release

(2015) S.-H. Lee et al.   JOURNAL OF NEUROSCIENCE

Hurt, tired and queasy: Specific variants in the ATPase domain of the TRAP1 mitochondrial chaperone are associated with common, chronic “functional” symptomatology including pain, fatigue and gastrointestinal dysmotility

(2015) Richard G. Boles et al.   MITOCHONDRION

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

ClinVar: public archive of interpretations of clinically relevant variants

(2015) Melissa J. Landrum et al.   NUCLEIC ACIDS RESEARCH

Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects

(2015) S Sadhasivam et al.   PHARMACOGENOMICS JOURNAL

Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis

(2015) Torsten Lowin et al.   ARTHRITIS RESEARCH & THERAPY

Consensus Genotyper for Exome Sequencing (CGES): improving the quality of exome variant genotypes

(2014) Vassily Trubetskoy et al.   BIOINFORMATICS

Rich annotation of DNA sequencing variants by leveraging the Ensembl Variant Effect Predictor with plugins

(2014) Michael Yourshaw et al.   BRIEFINGS IN BIOINFORMATICS

Integrating mapping-, assembly- and haplotype-based approaches for calling variants in clinical sequencing applications

(2014) Andy Rimmer et al.   NATURE GENETICS

A framework for the interpretation of de novo mutation in human disease

(2014) Kaitlin E Samocha et al.   NATURE GENETICS

OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders

(2014) Joanna S. Amberger et al.   NUCLEIC ACIDS RESEARCH

Multiple Sleep Alterations in Mice Lacking Cannabinoid Type 1 Receptors

(2014) Alessandro Silvani et al.   PLoS One

Cannabinoid Type 1 Receptors Transiently Silence Glutamatergic Nerve Terminals of Cultured Cerebellar Granule Cells

(2014) Jorge Ramírez-Franco et al.   PLoS One

Expanded Genetic Codes in Next Generation Sequencing Enable Decontamination and Mitochondrial Enrichment

(2014) Kevin J. McKernan et al.   PLoS One

Inhibition of Fatty Acid Binding Proteins Elevates Brain Anandamide Levels and Produces Analgesia

(2014) Martin Kaczocha et al.   PLoS One

Cannabinoid receptor 1 gene and irritable bowel syndrome: phenotype and quantitative traits

(2013) Michael Camilleri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders

(2013) Cristoforo Silvestri et al.   Cell Metabolism

CB1receptor signaling regulates social anxiety and memory

(2013) Y. Litvin et al.   GENES BRAIN AND BEHAVIOR

PhenoTips: Patient Phenotyping Software for Clinical and Research Use

(2013) Marta Girdea et al.   HUMAN MUTATION

dbNSFP v2.0: A Database of Human Non-synonymous SNVs and Their Functional Predictions and Annotations

(2013) Xiaoming Liu et al.   HUMAN MUTATION

DREAMing of a patent-free human genome for clinical sequencing

(2013) Kevin J McKernan et al.   NATURE BIOTECHNOLOGY

The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data

(2013) Sebastian Köhler et al.   NUCLEIC ACIDS RESEARCH

ClinVar: public archive of relationships among sequence variation and human phenotype

(2013) Melissa J. Landrum et al.   NUCLEIC ACIDS RESEARCH

Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications

(2013) Roger G. Pertwee   PROCEEDINGS OF THE NUTRITION SOCIETY

Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling

(2013) Erik Keimpema et al.   Scientific Reports

Qualimap: evaluating next-generation sequencing alignment data

(2012) Fernando García-Alcalde et al.   BIOINFORMATICS

Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex

(2012) Leonora E Long et al.   BMC NEUROSCIENCE

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

DECIPHER: web-based, community resource for clinical interpretation of rare variants in developmental disorders

(2012) G. J. Swaminathan et al.   HUMAN MOLECULAR GENETICS

Randomized pharmacodynamic and pharmacogenetic trial of dronabinol effects on colon transit in irritable bowel syndrome-diarrhea

(2012) B. S. Wong et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The diacylglycerol lipases: structure, regulation and roles in and beyond endocannabinoid signalling

(2012) M. Reisenberg et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Further evidence for association of polymorphisms in theCNR1gene with cocaine addiction: confirmation in an independent sample and meta-analysis

(2011) Toni-Kim Clarke et al.   ADDICTION BIOLOGY

The Non-Psychoactive Plant Cannabinoid, Cannabidiol Affects Cholesterol Metabolism-Related Genes in Microglial Cells

(2011) Neta Rimmerman et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

Variants at the Endocannabinoid Receptor CB1 Gene (CNR1) and Insulin Sensitivity, Type 2 Diabetes, and Coronary Heart Disease

(2011) Jose M. de Miguel-Yanes et al.   Obesity

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice

(2010) Y. Gao et al.   JOURNAL OF NEUROSCIENCE

Early onset of aging-like changes is restricted to cognitive abilities and skin structure in Cnr1−/− mice

(2010) Andras Bilkei-Gorzo et al.   NEUROBIOLOGY OF AGING

De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine

(2010) F. Riant et al.   NEUROLOGY

The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase α Mediates Retrograde Suppression of Synaptic Transmission

(2010) Asami Tanimura et al.   NEURON

The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults

(2009) Christie A. Hartman et al.   DRUG AND ALCOHOL DEPENDENCE

Variations in the cannabinoid receptor 1 gene predispose to migraine

(2009) Gabriella Juhasz et al.   NEUROSCIENCE LETTERS

Variants in theCNR1and theFAAHGenes and Adiposity Traits in the Community

(2009) Wolfgang Lieb et al.   Obesity

Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1

(2009) D Proudnikov et al.   PHARMACOGENOMICS JOURNAL

Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder

(2008) Ake T. Lu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence

(2008) Arpana Agrawal et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Beta-caryophyllene is a dietary cannabinoid

(2008) Jürg Gertsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA