Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

Developmental sensitivity in Schistosoma mansoni to puromycin to establish drug selection of transgenic schistosomes

(2018) Hong-Bin Yan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Formation and nucleolytic processing of Cas9-induced DNA breaks in human cells quantified by droplet digital PCR

(2018) Diego Dibitetto et al.   DNA REPAIR

Speed genome editing by transient CRISPR/Cas9 targeting and large DNA fragment deletion

(2018) Jing Luo et al.   JOURNAL OF BIOTECHNOLOGY

Multigene editing via CRISPR/Cas9 guided by a single-sgRNA seed in Arabidopsis

(2018) Zhiming Yu et al.   Journal of Integrative Plant Biology

Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments

(2018) Matthew C Canver et al.   Nature Protocols

Electroporation of mice zygotes with dual guide RNA/Cas9 complexes for simple and efficient cloning-free genome editing

(2018) Marie Teixeira et al.   Scientific Reports

Author Correction: Electroporation of mice zygotes with dual guide RNA/Cas9 complexes for simple and efficient cloning-free genome editing

(2018) Marie Teixeira et al.   Scientific Reports

Dectin-1/2–induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses

(2018) Maria M. M. Kaisar et al.   PLOS BIOLOGY

Targeted delivery of CRISPR-Cas9 ribonucleoprotein into arthropod ovaries for heritable germline gene editing

(2018) Duverney Chaverra-Rodriguez et al.   Nature Communications

High fidelity CRISPR/Cas9 increases precise monoallelic and biallelic editing events in primordial germ cells

(2018) Alewo Idoko-Akoh et al.   Scientific Reports

Mosaicism in CRISPR/Cas9-mediated genome editing

(2018) Maryam Mehravar et al.   DEVELOPMENTAL BIOLOGY

Comparative genomics of the major parasitic worms

(2018)   NATURE GENETICS

Development of a multi-locus CRISPR gene drive system in budding yeast

(2018) Yao Yan et al.   Scientific Reports

Characterization of Schistosoma japonicum CP1412 protein as a novel member of the ribonuclease T2 molecule family with immune regulatory function

(2017) Xue-Dan Ke et al.   Parasites & Vectors

Targeted mutagenesis in a human-parasitic nematode

(2017) Spencer S. Gang et al.   PLoS Pathogens

In Vivo Knockout of the Vegfa Gene by Lentiviral Delivery of CRISPR/Cas9 in Mouse Retinal Pigment Epithelium Cells

(2017) Andreas Holmgaard et al.   Molecular Therapy-Nucleic Acids

Method for Dual Viral Vector Mediated CRISPR-Cas9 Gene Disruption in Primary Human Endothelial Cells

(2017) Haixia Gong et al.   Scientific Reports

Production and glyco-engineering of immunomodulatory helminth glycoproteins in plants

(2017) Ruud H. P. Wilbers et al.   Scientific Reports

Association between omega-3 index and blood lipids in older Australians

(2016) Jessica J.A. Ferguson et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

(2016) Dominik Paquet et al.   NATURE

Analyzing CRISPR genome-editing experiments with CRISPResso

(2016) Luca Pinello et al.   NATURE BIOTECHNOLOGY

Single-cell genome sequencing: current state of the science

(2016) Charles Gawad et al.   NATURE REVIEWS GENETICS

Breaking-Cas—interactive design of guide RNAs for CRISPR-Cas experiments for ENSEMBL genomes

(2016) Juan C. Oliveros et al.   NUCLEIC ACIDS RESEARCH

Transgenesis in Strongyloides and related parasitic nematodes: historical perspectives, current functional genomic applications and progress towards gene disruption and editing

(2016) J. B. LOK et al.   PARASITOLOGY

ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes

(2016) Kazuto Yoshimi et al.   Nature Communications

HIV-1 Integrates Widely throughout the Genome of the Human Blood Fluke Schistosoma mansoni

(2016) Sutas Suttiprapa et al.   PLoS Pathogens

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

(2015) Marie Genin et al.   BMC CANCER

The Schistosoma mansoni T2 ribonuclease omega-1 modulates inflammasome-dependent IL-1β secretion in macrophages

(2015) Brian J. Ferguson et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Rapid reverse genetic screening using CRISPR in zebrafish

(2015) Arish N Shah et al.   NATURE METHODS

High-throughput functional genomics using CRISPR–Cas9

(2015) Ophir Shalem et al.   NATURE REVIEWS GENETICS

The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations

(2015) V. M. Gantz et al.   SCIENCE

CRISPR-Cas9-Mediated Genome Editing in Leishmania donovani

(2015) Wen-Wei Zhang et al.   mBio

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Human schistosomiasis

(2014) Daniel G Colley et al.   LANCET

DNA Repair Mechanisms and Their Biological Roles in the Malaria Parasite Plasmodium falciparum

(2014) A. H. Lee et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

(2014) Xuebing Wu et al.   NATURE BIOTECHNOLOGY

A PCR Based Protocol for Detecting Indel Mutations Induced by TALENs and CRISPR/Cas9 in Zebrafish

(2014) Chuan Yu et al.   PLoS One

Halting harmful helminths

(2014) K. F. Hoffmann et al.   SCIENCE

Pseudotyped murine leukemia virus for schistosome transgenesis: approaches, methods and perspectives

(2014) Victoria H. Mann et al.   TRANSGENIC RESEARCH

Omega-1 knockdown in Schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivo

(2014) Jana Hagen et al.   Nature Communications

Neglected Parasitic Infections and Poverty in the United States

(2014) Peter J. Hotez   PLoS Neglected Tropical Diseases

Ten Global “Hotspots” for the Neglected Tropical Diseases

(2014) Peter J. Hotez   PLoS Neglected Tropical Diseases

Venus Kinase Receptors Control Reproduction in the Platyhelminth Parasite Schistosoma mansoni

(2014) Mathieu Vanderstraete et al.   PLoS Pathogens

Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the Stage

(2013) Ludovic Deriano et al.   Annual Review of Genetics

Adult somatic stem cells in the human parasite Schistosoma mansoni

(2013) James J. Collins III et al.   NATURE

Genetic and Molecular Basis of Drug Resistance and Species-Specific Drug Action in Schistosome Parasites

(2013) C. L. L. Valentim et al.   SCIENCE

Functional genomic characterization of neoblast-like stem cells in larval Schistosoma mansoni

(2013) Bo Wang et al.   eLife

Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor

(2012) Bart Everts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole-genome sequence of Schistosoma haematobium

(2012) Neil D Young et al.   NATURE GENETICS

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Th2 responses in schistosomiasis

(2012) Keke Fairfax et al.   Seminars in Immunopathology

A Systematically Improved High Quality Genome and Transcriptome of the Human Blood Fluke Schistosoma mansoni

(2012) Anna V. Protasio et al.   PLoS Neglected Tropical Diseases

Germline Transgenesis and Insertional Mutagenesis in Schistosoma mansoni Mediated by Murine Leukemia Virus

(2012) Gabriel Rinaldi et al.   PLoS Pathogens

The use of THP-1 cells as a model for mimicking the function and regulation of monocytes and macrophages in the vasculature

(2011) Zhenyu Qin   ATHEROSCLEROSIS

The S. mansoni glycoprotein ω-1 induces Foxp3 expression in NOD mouse CD4+ T cells

(2011) Paola Zaccone et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An antibiotic selection marker for schistosome transgenesis

(2011) Gabriel Rinaldi et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Towards an understanding of the epigenetics of schistosomes: a comparative epigenomic study

(2011) Julie Mireille Joé Lepesant et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Genetic manipulation of schistosomes – progress with integration competent vectors

(2011) SUTAS SUTTIPRAPA et al.   PARASITOLOGY

Prototypic chromatin insulator cHS4 protects retroviral transgene from silencing in Schistosoma mansoni

(2011) Sutas Suttiprapa et al.   TRANSGENIC RESEARCH

Human U6 promoter drives stronger shRNA activity than its schistosome orthologue in Schistosoma mansoni and human fibrosarcoma cells

(2011) Raphaël Duvoisin et al.   TRANSGENIC RESEARCH

Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni

(2011) Kathrin K. Geyer et al.   Nature Communications

Establishing Transgenic Schistosomes

(2011) Victoria H. Mann et al.   PLoS Neglected Tropical Diseases

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses

(2010) M. Ritter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T2 Family ribonucleases: ancient enzymes with diverse roles

(2010) Natalie Luhtala et al.   TRENDS IN BIOCHEMICAL SCIENCES

Myeloid Cells in the Tumor Microenvironment: Modulation of Tumor Angiogenesis and Tumor Inflammation

(2010) Michael C. Schmid et al.   Journal of Oncology

DNA Repair in Mammalian Cells

(2009) B. Pardo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The embryonic development of Schistosoma mansoni eggs: proposal for a new staging system

(2009) Arnon D. Jurberg et al.   DEVELOPMENT GENES AND EVOLUTION

A comparative proteomic study of the undeveloped and developed Schistosoma mansoni egg and its contents: The miracidium, hatch fluid and secretions

(2009) William Mathieson et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Omega-1, a glycoprotein secreted bySchistosoma mansonieggs, drives Th2 responses

(2009) Bart Everts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)

(2009) Svenja Steinfelder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs

(2009) G. Schramm et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The genome of the blood fluke Schistosoma mansoni

(2009) Matthew Berriman et al.   NATURE

Culture for genetic manipulation of developmental stages of Schistosoma mansoni

(2009) VICTORIA H. MANN et al.   PARASITOLOGY

Helminth infections: the great neglected tropical diseases

(2008) Peter J. Hotez et al.   JOURNAL OF CLINICAL INVESTIGATION