Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy

Immunology: A tolerant approach

(2014) Ken Garber   NATURE

Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report

(2013) A. Wesley Burks et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

Modification of the FoxP3 Transcription Factor Principally Affects Inducible T Regulatory Cells in a Model of Experimental Autoimmune Encephalomyelitis

(2013) Johan Verhagen et al.   PLoS One

Birch pollen immunotherapy results in long-term loss of Bet v 1–specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies

(2012) Christian Möbs et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Oral Immunotherapy for Treatment of Egg Allergy in Children

(2012) A. Wesley Burks et al.   NEW ENGLAND JOURNAL OF MEDICINE

A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response

(2011) Pooja Varshney et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-27 Promotes IL-10 Production by Effector Th1 CD4+ T Cells: A Critical Mechanism for Protection from Severe Immunopathology during Malaria Infection

(2011) A. P. Freitas do Rosario et al.   JOURNAL OF IMMUNOLOGY

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

(2011) Yasutaka Motomura et al.   NATURE IMMUNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse

(2011) J. T. Eppig et al.   NUCLEIC ACIDS RESEARCH

Disease Ontology: a backbone for disease semantic integration

(2011) L. M. Schriml et al.   NUCLEIC ACIDS RESEARCH

Antigen-specific immunotherapy of autoimmune and allergic diseases

(2010) Catherine A Sabatos-Peyton et al.   CURRENT OPINION IN IMMUNOLOGY

Transcriptome Analysis of Early Organogenesis in Human Embryos

(2010) Hai Fang et al.   DEVELOPMENTAL CELL

Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNγ

(2010) G. Fousteri et al.   DIABETOLOGIA

Antigenic strength controls the generation of antigen-specific IL-10-secreting T regulatory cells

(2010) Leona Gabryšová et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

(2010) Lionel Apetoh et al.   NATURE IMMUNOLOGY

Tolerization with Hsp65 induces protection against adjuvant-induced arthritis by modulating the antigen-directed interferon-γ, interleukin-17, and antibody responses

(2009) Shailesh R. Satpute et al.   ARTHRITIS AND RHEUMATISM

Epitope-specific immunotherapy of rheumatoid arthritis: Clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial

(2009) Eva C. Koffeman et al.   ARTHRITIS AND RHEUMATISM

Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose

(2009) Margarida Saraiva et al.   IMMUNITY

Antigen-specific tolerance inhibits autoimmune uveitis in pre-sensitized animals by deletion and CD4+ CD25+ T-regulatory cells

(2009) Bharati Matta et al.   IMMUNOLOGY AND CELL BIOLOGY

Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10–secreting Th1 cells

(2009) Leona Gabryšová et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peptide immunotherapy in allergic asthma generates IL-10–dependent immunological tolerance associated with linked epitope suppression

(2009) John D. Campbell et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

(2009) C. Pot et al.   JOURNAL OF IMMUNOLOGY

CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2

(2009) T. Okamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study

(2008) S. L. Thrower et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure

(2008) Flurina Meiler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reactome knowledgebase of human biological pathways and processes

(2008) L. Matthews et al.   NUCLEIC ACIDS RESEARCH