The split personality of regulatory T cells in HIV infection

Cutting Edge: Experimentally Induced Immune Activation in Natural Hosts of Simian Immunodeficiency Virus Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion

(2014) I. Pandrea et al.   JOURNAL OF IMMUNOLOGY

Immune Activation Driven by CTLA-4 Blockade Augments Viral Replication at Mucosal Sites in Simian Immunodeficiency Virus Infection

(2014) V. Cecchinato et al.   JOURNAL OF IMMUNOLOGY

Naive Precursors of Human Regulatory T Cells Require FoxP3 for Suppression and Are Susceptible to HIV Infection

(2014) A. K. Antons et al.   JOURNAL OF IMMUNOLOGY

Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers

(2012) Mathieu Angin et al.   AIDS

Chronic progressive HIV-1 infection is associated with elevated levels of myeloid-derived suppressor cells

(2012) Thomas Vollbrecht et al.   AIDS

Regulatory T Cell Frequencies Do Not Correlate with Breadth or Magnitude of HIV-1-Specific T Cell Responses

(2012) Mathieu Angin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Effects of Recombinant Human Interleukin 7 on T-Cell Recovery and Thymic Output in HIV-Infected Patients Receiving Antiretroviral Therapy: Results of a Phase I/IIa Randomized, Placebo-Controlled, Multicenter Study

(2012) Y. Lévy et al.   CLINICAL INFECTIOUS DISEASES

Cutting Edge: CTLA-4 on Effector T Cells Inhibits In Trans

(2012) E. Corse et al.   JOURNAL OF IMMUNOLOGY

Early and Long-Lasting Alteration of Effector CD45RA−Foxp3high Regulatory T-Cell Homeostasis During HIV Infection

(2012) Federico Simonetta et al.   JOURNAL OF INFECTIOUS DISEASES

Preserved Function of Regulatory T Cells in Chronic HIV-1 Infection Despite Decreased Numbers in Blood and Tissue

(2012) Mathieu Angin et al.   JOURNAL OF INFECTIOUS DISEASES

CD4+ CD25+ Regulatory T Cells Impair HIV-1-Specific CD4 T Cell Responses by Upregulating Interleukin-10 Production in Monocytes

(2012) D. S. Kwon et al.   JOURNAL OF VIROLOGY

Memory and naive-like regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremia

(2011) Russell B. Foxall et al.   AIDS

Level of double negative T cells, which produce TGF-β and IL-10, predicts CD8 T-cell activation in primary HIV-1 infection

(2011) Gaël Petitjean et al.   AIDS

Human FoxP3+ regulatory T cells in systemic autoimmune diseases

(2011) Makoto Miyara et al.   AUTOIMMUNITY REVIEWS

Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism

(2011) M. E. Moreno-Fernandez et al.   BLOOD

Elevated effector cell sensitivity to Treg-cell suppression that is not associated with reduced Th17-cell expression distinguishes HIV+asymptomatic subjects from progressors

(2011) Georgina S. Thorborn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tregs and infections: on the potential value of modifying their function

(2011) Sharvan Sehrawat et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Increased Frequency of Regulatory T Cells Accompanies Increased Immune Activation in Rectal Mucosae of HIV-Positive Noncontrollers

(2011) J. M. Shaw et al.   JOURNAL OF VIROLOGY

Protective HIV-specific CD8+ T cells evade Treg cell suppression

(2011) Shokrollah Elahi et al.   NATURE MEDICINE

A Low T Regulatory Cell Response May Contribute to Both Viral Control and Generalized Immune Activation in HIV Controllers

(2011) Peter W. Hunt et al.   PLoS One

Frequency of Circulating Regulatory T Cells Increases during Chronic HIV Infection and Is Largely Controlled by Highly Active Antiretroviral Therapy

(2011) Pietro Presicce et al.   PLoS One

Two modes of immune suppression by Foxp3+ regulatory T cells under inflammatory or non-inflammatory conditions

(2011) Tomoyuki Yamaguchi et al.   SEMINARS IN IMMUNOLOGY

CD39/Adenosine Pathway Is Involved in AIDS Progression

(2011) Maria Nikolova et al.   PLoS Pathogens

HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses

(2010) Rachel E Owen et al.   AIDS

HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells

(2010) Andrew Prendergast et al.   AIDS

Immune activation, apoptosis, and Treg activity are associated with persistently reduced CD4+ T-cell counts during antiretroviral therapy

(2010) Stefania Piconi et al.   AIDS

Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome

(2010) L. R. V. Antonelli et al.   BLOOD

Increased Turnover of FoxP3high Regulatory T Cells Is Associated With Hyperactivation and Disease Progression of Chronic HIV-1 Infection

(2010) Shaojun Xing et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Normalization of FoxP3+ Regulatory T Cells in Response to Effective Antiretroviral Therapy

(2010) Martin Montes et al.   JOURNAL OF INFECTIOUS DISEASES

Comprehensive Analysis of Frequency and Phenotype of T Regulatory Cells in HIV Infection: CD39 Expression of FoxP3+ T Regulatory Cells Correlates with Progressive Disease

(2010) J. Schulze zur Wiesch et al.   JOURNAL OF VIROLOGY

Regulatory T Cell Suppression of Gag-Specific CD8+ T Cell Polyfunctional Response After Therapeutic Vaccination of HIV-1-Infected Patients on ART

(2010) Bernard J. C. Macatangay et al.   PLoS One

Increased Sensitivity of CD4+ T-Effector Cells to CD4+CD25+ Treg Suppression Compensates for Reduced Treg Number in Asymptomatic HIV-1 Infection

(2010) Georgina Thorborn et al.   PLoS One

CD4+ T Cell Depletion, Immune Activation and Increased Production of Regulatory T Cells in the Thymus of HIV-Infected Individuals

(2010) Alessandra Bandera et al.   PLoS One

Relationship between Regulatory T Cells and Immune Activation in Human Immunodeficiency Virus-Infected Patients Interrupting Antiretroviral Therapy

(2010) Laurence Weiss et al.   PLoS One

FOXP3 Expression Is Upregulated in CD4+T Cells in Progressive HIV-1 Infection and Is a Marker of Disease Severity

(2010) Melinda S. Suchard et al.   PLoS One

In vivo expansion of naive and activated CD4+CD25+FOXP3+ regulatory T cell populations in interleukin-2-treated HIV patients

(2010) L. Weiss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of TH17 to Regulatory T Cells in HIV Disease

(2010) D. Favre et al.   Science Translational Medicine

Th17 cells, HIV and the gut mucosal barrier

(2010) Satya Dandekar et al.   Current Opinion in HIV and AIDS

Prevalence and comparative characteristics of long-term nonprogressors and HIV controller patients in the French Hospital Database on HIV

(2009) Sophie Grabar et al.   AIDS

Regulatory T Cell Expansion and Immune Activation during Untreated HIV Type 1 Infection Are Associated with Disease Progression

(2009) Weiwei Cao et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Regulatory T Cells in the Control of Host-Microorganism Interactions

(2009) Yasmine Belkaid et al.   Annual Review of Immunology

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells

(2009) C. Becker et al.   BLOOD

Proliferation of weakly suppressive regulatory CD4+ T cells is associated with over-active CD4+ T-cell responses in HIV-positive patients with mycobacterial immune restoration disease

(2009) Nabila Seddiki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HIV-1 binding to CD4 on CD4+CD25+ regulatory T cells enhances their suppressive function and induces them to home to, and accumulate in, peripheral and mucosal lymphoid tissues: an additional mechanism of immunosuppression

(2009) J. Ji et al.   INTERNATIONAL IMMUNOLOGY

CD4+ and CD8+ T Cells Expressing FoxP3 in HIV-Infected Patients Are Phenotypically Distinct and Influenced by Disease Severity and Antiretroviral Therapy

(2009) Andrew Lim et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Decreased Immune Activation in Resistance to HIV‐1 Infection Is Associated with an Elevated Frequency of CD4+CD25+FOXP3+Regulatory T Cells

(2009) Catherine M. Card et al.   JOURNAL OF INFECTIOUS DISEASES

CD4+CD25+/hiCD127loPhenotype Does Not Accurately Identify Regulatory T Cells in All Populations of HIV‐Infected Persons

(2009) Maria del Mar del Pozo‐Balado et al.   JOURNAL OF INFECTIOUS DISEASES

Human Regulatory T Cells Are Targets for Human Immunodeficiency Virus (HIV) Infection, and Their Susceptibility Differs Depending on the HIV Type 1 Strain

(2009) M. E. Moreno-Fernandez et al.   JOURNAL OF VIROLOGY

Interleukin-2 Therapy in Patients with HIV Infection

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells

(2009) R. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-specific regulatory T cells are associated with higher CD4 cell counts in primary infection

(2008) Hassen Kared et al.   AIDS

High frequency and proliferation of CD4+FOXP3+ Treg in HIV-1-infected patients with low CD4 counts

(2008) Xiuqiong Bi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tim-3-Galectin-9 pathway involves the suppression induced by CD4+CD25+ regulatory T cells

(2008) Feng Wang et al.   IMMUNOBIOLOGY

The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8+T cells in HIV-1-infected typical progressors, but not in long-term non-progressors

(2008) Yanmei Jiao et al.   IMMUNOLOGY

HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase–dependent mechanism

(2008) Olivier Manches et al.   JOURNAL OF CLINICAL INVESTIGATION

Preservation of FoxP3+ Regulatory T Cells in the Peripheral Blood of Human Immunodeficiency Virus Type 1-Infected Elite Suppressors Correlates with Low CD4+ T-Cell Activation

(2008) A. J. Chase et al.   JOURNAL OF VIROLOGY

FOXP3 inhibits HIV-1 infection of CD4 T-cells via inhibition of LTR transcriptional activity

(2008) Nithianandan Selliah et al.   VIROLOGY

Relationship between T Cell Activation and CD4+T Cell Count in HIV‐Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy

(2007) Peter W. Hunt et al.   JOURNAL OF INFECTIOUS DISEASES

Immune activation and inflammation in HIV-1 infection: causes and consequences

(2007) V Appay et al.   JOURNAL OF PATHOLOGY