Chemogenomic model identifies synergistic drug combinations robust to the pathogen microenvironment

Uncovering the mechanisms of Acinetobacter baumannii virulence

(2017) Christian M. Harding et al.   NATURE REVIEWS MICROBIOLOGY

Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis

(2017) Murat Cokol et al.   Science Advances

An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

(2016) Jennifer O'Neil et al.   MOLECULAR CANCER THERAPEUTICS

Chemogenomics and orthology‐based design of antibiotic combination therapies

(2016) Sriram Chandrasekaran et al.   Molecular Systems Biology

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

The Resistome: A Comprehensive Database of Escherichia coli Resistance Phenotypes

(2016) James D. Winkler et al.   ACS Synthetic Biology

Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism

(2016) Jan Wildenhain et al.   Scientific Data

Unconventional screening approaches for antibiotic discovery

(2015) Maya A. Farha et al.   Annals of the New York Academy of Sciences

Combination Therapy for Extreme Drug–Resistant Acinetobacter baumannii

(2015) Brad Spellberg et al.   CRITICAL CARE MEDICINE

Systematic discovery of drug interaction mechanisms

(2015) G. Chevereau et al.   Molecular Systems Biology

Antibiotic efficacy is linked to bacterial cellular respiration

(2015) Michael A. Lobritz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells

(2015) Anil Korkut et al.   eLife

Antagonism between Bacteriostatic and Bactericidal Antibiotics Is Prevalent

(2014) Paolo S. Ocampo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Unraveling the Biology of a Fungal Meningitis Pathogen Using Chemical Genetics

(2014) Jessica C.S. Brown et al.   CELL

A community computational challenge to predict the activity of pairs of compounds

(2014) Mukesh Bansal et al.   NATURE BIOTECHNOLOGY

Antibiotics induce redox-related physiological alterations as part of their lethality

(2014) D. J. Dwyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis

(2014) Madhumitha Nandakumar et al.   Nature Communications

On the essentiality of lipopolysaccharide to Gram-negative bacteria

(2013) Ge Zhang et al.   CURRENT OPINION IN MICROBIOLOGY

OrtholugeDB: a bacterial and archaeal orthology resource for improved comparative genomic analysis

(2012) Matthew D. Whiteside et al.   NUCLEIC ACIDS RESEARCH

Defining principles of combination drug mechanisms of action

(2012) J. R. Pritchard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism-independent method for predicting response to multidrug combinations in bacteria

(2012) Kevin Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Protein Dynamics in Drug Combinations: a Linear Superposition of Individual-Drug Responses

(2010) Naama Geva-Zatorsky et al.   CELL

Phenotypic Landscape of a Bacterial Cell

(2010) Robert J. Nichols et al.   CELL

Rifampin Combination Therapy for Nonmycobacterial Infections

(2010) G. N. Forrest et al.   CLINICAL MICROBIOLOGY REVIEWS

Carbon metabolism of intracellular bacterial pathogens and possible links to virulence

(2010) Wolfgang Eisenreich et al.   NATURE REVIEWS MICROBIOLOGY