Article
Materials Science, Multidisciplinary
Nishant Kumar, Sajid Fazal, Eijiro Miyako, Kazuaki Matsumura, Robin Rajan
Summary: Cancer is a leading cause of death globally, causing physical, emotional, and financial strain on individuals, families, and healthcare systems. The development of nanoparticle-based drug delivery systems and synthetic biodegradable polypeptides and polymers offers new hope for cancer treatment, overcoming challenges such as harmful side effects and drug resistance. Additionally, immunotherapies and bacteria-based therapies show promising selectivity and efficacy in treating various cancers.
Article
Chemistry, Multidisciplinary
Yu Zhang, Sheng Ma, Xinming Liu, Yudi Xu, Jiayu Zhao, Xinghui Si, Hongxiang Li, Zichao Huang, Zhenxin Wang, Zhaohui Tang, Wantong Song, Xuesi Chen
Summary: A programmable immune activation nanomedicine (PIAN) is reported in this study, which sequentially finishes multiple steps after intravenous injection and elicits robust antitumor immunity in situ. This innovative approach provides a new framework for designing programmable nanomedicine as an in situ cancer vaccine for cancer immunotherapy.
ADVANCED MATERIALS
(2021)
Article
Engineering, Biomedical
David Caballero, Catarina M. Abreu, Ana C. Lima, Nuno N. Neves, Rui L. Reis, Subhas C. Kundu
Summary: Traditional cancer treatment approaches are becoming obsolete, leading to more patients failing to respond to treatments. Personalized genetic profiling offers a more accurate method of treatment, but still faces issues like low local drug efficacy. Efforts are now focused on developing precision medicine-based strategies to improve cancer treatment efficiency.
Article
Instruments & Instrumentation
Isra Rana, Jaeeun Oh, Juwon Baig, Jeong Hyun Moon, Sejin Son, Jutaek Nam
Summary: The immune system can target and kill cancer cells, and nanocarriers offer a promising approach to enhance cancer immunotherapy by boosting immune activity and improving drug delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Tania B. B. Lopez-Mendez, Miguel Sanchez-Alvarez, Flavia Trionfetti, Jose L. Pedraz, Marco Tripodi, Marco Cordani, Raffaele Strippoli, Juan Gonzalez-Valdivieso
Summary: In recent years, nanotechnology has provided new tools for the more effective treatment of cancer. Specifically, advances in biomaterials designed for drug delivery have the potential to overcome the limitations and side effects of traditional therapies. However, the use of autophagy in cancer treatment is currently limited due to contextual effects, low bioavailability, and non-targeted delivery of autophagy modulatory compounds. By combining the characteristics of nanoparticles with autophagy modulators, these drugs may become safer and more effective for cancer treatment.
CELL AND BIOSCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Yushu Wang, Bin Wang, Kao Li, Maosheng Wang, Haihua Xiao
Summary: The review summarizes the current state-of-art metallic nanomedicine for enhancing the efficacy of cancer immunotherapy. It points out that metal-based nanomedicine can reverse immune suppression, but there are still obstacles and challenges to be overcome.
MATERIALS TODAY ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Haijing Qu, Longmeng Li, Han Chen, Menghuan Tang, Wei Cheng, Tzu-yin Lin, Lingyan Li, Bin Li, Xiangdong Xue
Summary: In this study, researchers developed nanoparticles with strong photo/immune therapeutic effects by integrating a photosensitizer and a Toll-like receptor 7/8 agonist. These nanoparticles can directly inhibit tumor growth, promote the immune response, and reverse the suppressive tumor immune microenvironment. They have the potential to enhance the effectiveness of immunotherapy and phototherapy in cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Nanoscience & Nanotechnology
Cherylette Anne Alexander, Yi Yan Yang
Summary: Cancer immunotherapy has gained popularity for its ability to activate patients' immune systems to fight tumors, while interest in cancer nanomedicine has decreased. Combining these two approaches has been proposed as a solution to the challenges faced by cancer immunotherapy, leading to a revival of cancer nanomedicine.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Qingrong Dong, Tingyu Xue, Haili Yan, Fang Liu, Ruixue Liu, Kun Zhang, Yu Chong, Jiangfeng Du, Hui Zhang
Summary: This review highlights recent advances in the applications of nano-biomaterials for radiotherapy-activated immunotherapy. It discusses the combination of nano-biomaterials with immune checkpoint inhibitors to enhance tumor immune response, as well as various nano-biomaterials-enabled tumor oxygenation strategies. The review also summarizes the rapid development of immune modulatable nano-biomaterials and discusses the key challenge in their development for tumor radio-immunotherapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Chemistry, Physical
Zhongyuan Guo, Audrey T. Zhu, Ronnie H. Fang, Liangfang Zhang
Summary: Phototherapy is a promising cancer treatment approach that utilizes light irradiation to induce local hyperthermia and reactive oxygen species production for eradicating cancer cells. Nanoparticles, with their small size and tunable properties, have been widely used as carriers to enhance the biocompatibility and tumor-targeted delivery of phototherapeutic agents. Recent developments have focused on using nanoparticle-based phototherapy to achieve durable and systemic antitumor responses through immune modulation.
Review
Pharmacology & Pharmacy
Shanshan Hou, Muhammad Hasnat, Ziwei Chen, Yinong Liu, Mirza Muhammad Faran Ashraf Baig, Fuhe Liu, Zelong Chen
Summary: This article outlines the applications of nanomedicine in cancer treatment, focusing on chemotherapy, gene therapy, and immunotherapy. Addressing common problems in these treatment modalities, the article discusses how nanomedicine can be combined with them, provides typical examples, and summarizes the advantages brought by the application of nanomedicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yasmeen Shamiya, Shruthi Polla Ravi, Ali Coyle, Subrata Chakrabarti, Arghya Paul
Summary: This article reviews emerging therapeutic nanoparticles for treating diabetic wounds and discusses their discrete delivery mechanisms and sites of action. The current challenges of these nanoengineered materials for successful clinical translation are critically assessed, along with their potential for growth in the clinical marketplace.
DRUG DISCOVERY TODAY
(2022)
Review
Chemistry, Multidisciplinary
Meng-Jie Zhang, Yuan-Yuan Wang, Lin-Lin Han, Xin-Yang Liu, Yun-Yun Xie, Zhigang Xu, Zhi-Jun Sun
Summary: Cancer immunotherapy has the potential to revolutionize malignant tumor treatment, but low immune response rates limit its effectiveness. This review discusses the design strategies and mechanisms of biomaterials to induce pyroptosis and their significance in tumor immunotherapy. Tailored biomaterials can elicit pyroptosis, fueling a strong antitumor immune response.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Mohammad Doroudian, Saba Zanganeh, Elham Abbasgholinejad, Seamas C. Donnelly
Summary: Lung cancer is a leading cause of cancer death globally. Nanoparticles have great potential and challenges in lung cancer immunotherapy, as they can precisely target and regulate immune responses.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Yunfei Yi, Mian Yu, Wen Li, Dunwan Zhu, Lin Mei, Meitong Ou
Summary: The development of therapeutic cancer vaccines using nanotechnology has great potential in improving the limitations of current immunotherapies. Nanoparticles enhance vaccine stability and antigen recognition through their small size, while surface modifications allow targeted delivery. Nanocarriers with adjuvant effect also improve vaccine efficacy. Additionally, nanoparticle-mediated chemotherapy and radiotherapy induce the release of tumor antigens, simulating anti-tumor immune responses. These vaccine-like nanomedicines can effectively eliminate tumors and prevent recurrence and metastasis. This article presents recent advancements in nanoparticle-based antigen delivery for in situ anti-tumor vaccination and discusses the remaining opportunities and challenges for clinical translation.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Soyoung Son, Jung Min Shin, Sol Shin, Chan Ho Kim, Jae Ah Lee, Hyewon Ko, Eun Sook Lee, Jae Min Jung, Jeongyun Kim, Jae Hyung Park
Summary: The study demonstrates that macitentan can modulate the desmoplastic tumor microenvironment by regulating the function of cancer-associated fibroblasts, attenuating the biogenesis of cancer cell-derived exosomes, and modulating T cell subsets and distribution in the TME. These results indicate that macitentan effectively reorganizes the immunosuppressive TME and exhibits synergistic antitumor effects in combination with ICT.
Article
Multidisciplinary Sciences
Dong Gil You, Gyeong Taek Lim, Seunglee Kwon, Wooram Um, Byeong Hoon Oh, Seok Ho Song, Jungmi Lee, Dong-Gyu Jo, Yong Woo Cho, Jae Hyung Park
Summary: Metabolically engineered exosomes have been shown to effectively reprogram macrophages' immune phenotype, demonstrating potential therapeutic efficacy in treating rheumatoid arthritis.
Article
Chemistry, Multidisciplinary
Jung Min Shin, Chan-Hyeong Lee, Soyoung Son, Chan Ho Kim, Jae Ah Lee, Hyewon Ko, Sol Shin, Seok Ho Song, Seong-Sik Park, Ju-Hyun Bae, Ju-Mi Park, Eun-Ji Choe, Moon-Chang Baek, Jae Hyung Park
Summary: Sulfisoxazole significantly decreases exosomal PD-L1 levels and reinvigorates exhausted T cells when orally administered, showing potential to improve the response rate of anti-PD-1 antibodies in cancer treatment.
Article
Engineering, Biomedical
Jueun Jeon, Been Yoon, Wooram Um, Yeari Song, Jeongjin Lee, Dong Gil You, Jae Yoon An, Jae Hyung Park
Summary: Sonodynamic therapy (SDT) has emerged as a promising alternative to photodynamic therapy for treating deeply located tumors accessible by ultrasound. However, the therapeutic potential of conventional sonosensitizers is limited. This study reports immunostimulatory nanoparticles (iCRET NPs) for sonoimmunotherapy, which amplify the reactive oxygen species (ROS) production and induce immunogenic cell death in the tumor microenvironment (TME). The iCRET NPs effectively inhibit tumor growth and metastasis when combined with anti-PD-1 antibodies.
Article
Engineering, Biomedical
Jae Ah Lee, Jung Min Shin, Seok Ho Song, Chan Ho Kim, Soyoung Son, Sol Shin, Jae Hyung Park
Summary: Therapeutic cancer vaccines have the potential to activate highly specific cytotoxic T cells, making them an attractive option for personalized cancer immunotherapy. However, their low immunogenicity has limited their use in clinical settings. To overcome this limitation, researchers have developed 'find-me' signaling polymeric microparticles (F-PMs) that efficiently recruit dendritic cells (DCs) and facilitate antigen presentation. When injected into tumor-bearing mice, F-PMs significantly increase mature DCs in the lymph nodes, resulting in effective tumor inhibition. Moreover, co-administration of F-PMs and an immune checkpoint inhibitor leads to a higher enrichment of CD8+ cytotoxic T cells in the tumor microenvironment. This study demonstrates the potential of F-PMs as a promising therapeutic option for cancer treatment.
Article
Chemistry, Multidisciplinary
Suyeon Kim, Roun Heo, Seok Ho Song, Kwon-Ho Song, Jung Min Shin, Se Jin Oh, Hyo-Jung Lee, Jo Eun Chung, Jae Hyung Park, Tae Woo Kim
Summary: Foreignization of tumor cells by delivering a non-self foreign antigen into tumors is an effective strategy for tumor rejection. However, immune-suppressive factors in the tumor microenvironment limit the immune response against tumor antigens. Blocking PD-L1 on both tumor cells and dendritic cells can enhance the induction of tumor-reactive T cells and strengthen the anti-tumor immunity initiated by tumor-foreignization.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Physical
Jueun Jeon, Dong Gil You, Anup Dey, Been Yoon, Yuce Li, Jae Hyung Park
Summary: Chemiluminescence is a favorable technique for reactive oxygen species (ROS) imaging, but its short duration limits its clinical applications. In this work, nanoparticles consisting of a self-immolative polymer (SIP) and hydrophobic dyes are discovered to induce sustained chemiluminescence, which is available for long-term in vivo ROS imaging. These SIP-based nanoparticles generate highly efficient ROS-selective chemiluminescence signals and have potential as contrast agents for in vivo disease diagnosis.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Seok Ho Song, Torsha Ghosh, Dong Gil You, Hyeyeon Joo, Jeongjin Lee, Jaeah Lee, Chan Ho Kim, Jueun Jeon, Sol Shin, Jae Hyung Park
Summary: This study investigates the use of tumor microenvironment-responsive polymer chains to mask immune checkpoint antibodies, which can mitigate immune-related adverse events (irAEs) and selectively target tumors. The results support a strategy to separate toxicity from efficacy in antibody-based therapies and demonstrate the translational potential for cancer immunotherapy.
Article
Engineering, Biomedical
Jueun Jeon, Been Yoon, Anup Dey, Seok Ho Song, Yuce Li, Hyeyeon Joo, Jae Hyung Park
Summary: To enhance the immunogenicity of Doxorubicin (DOX), researchers developed a ROS-responsive self-immolative polymer (R-SIP) that efficiently destroys redox homeostasis in cancer cells. The DOX-encapsulated R-SIP (DR-SIP) induces immunogenic cell death and promotes dendritic cell maturation. In vivo studies showed that DR-SIP significantly inhibits tumor growth.
Article
Engineering, Biomedical
Ngoc Phung Ly, Hwa Seung Han, Myungsuk Kim, Jae Hyung Park, Ki Young Choi
Summary: This article provides a comprehensive introduction to plant-derived vesicles (PDVs), including their biological characteristics, purification methods, and a summary of their current development potential for cancer therapy.
BIOACTIVE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Wooram Um, Pramod E. K. Kumar, Jeongjin Lee, Chan Ho Kim, Dong Gil You, Jae Hyung Park
Summary: Sonodynamic therapy (SDT) has emerged as a promising alternative to conventional cancer therapies due to its safety and cost-effectiveness. However, the insufficient reactive oxygen species (ROS) production of current sonosensitizers has hindered its clinical application. Recent nanomaterial-based SDT strategies aim to improve sonosensitizer efficiency and enhance oxidative stress for potential anti-tumor immunity.
CHEMICAL COMMUNICATIONS
(2021)
