Journal
DRUG DISCOVERY TODAY
Volume 27, Issue 4, Pages 1156-1166Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2021.11.024
Keywords
Nanomedicine; Wound healing; Drug delivery; Biomaterials; Polymers; Regenerative medicine
Categories
Funding
- Canada Research Chairs Program of the Natural Sciences and Engineering Research Council (NSERC) of Canada
- NSERC
- New Frontiers in Research Fund (NFRF) - Exploration Stream
- Early Research Award (ERA) from Province of Ontario
- Wolfe-Western Fellowship At-Large for Outstanding Newly Recruited Research Scholar
- Centre for Advanced Materials and Biomaterials Research (CAMBR) Seed Grant
- Western Strategic Support-CIHR Seed Grant
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This article reviews emerging therapeutic nanoparticles for treating diabetic wounds and discusses their discrete delivery mechanisms and sites of action. The current challenges of these nanoengineered materials for successful clinical translation are critically assessed, along with their potential for growth in the clinical marketplace.
Diabetes mellitus is a chronic disease characterized by increased blood glucose levels, leading to damage of the nerves blood vessels, subsequently manifesting as organ failures, wounds, or ulcerations. Wounds in patients with diabetes are further complicated because of reduced cytokine responses, infection, poor vascularization, and delayed healing processes. Surface-functionalized and bioengineered nanoparticles (NPs) have recently gained attention as emerging treatment modalities for wound healing in diabetes. Here, we review emerging therapeutic NPs to treat diabetic wounds and highlight their discrete delivery mechanisms and sites of action. We further critically assess the current challenges of these nanoengineered materials for successful clinical translation and discuss their potential for growth in the clinical marketplace.
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