Biomaterials Elicit Pyroptosis Enhancing Cancer Immunotherapy

A Microenvironment Dual‐Responsive Nano‐Drug Equipped with PD‐L1 Blocking Peptide Triggers Immunogenic Pyroptosis for Prostate Cancer Self‐Synergistic Immunotherapy

(2023) He Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Natural Cell Patches: Melanin Nanoparticles for MR Imaging‐Guided Antiatherosclerosis Therapy via Attenuating Macrophage Pyroptosis

(2023) Ziyue Zu et al.   ADVANCED FUNCTIONAL MATERIALS

ZIF‐8 Nanoparticles Evoke Pyroptosis for High‐Efficiency Cancer Immunotherapy

(2023) Binbin Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioengineering of BRAF and COX2 inhibitor nanogels to boost the immunotherapy of melanoma via pyroptosis

(2023) Meng-Jie Zhang et al.   CHEMICAL COMMUNICATIONS

Therapy with oncolytic viruses: progress and challenges

(2023) Sophia Z. Shalhout et al.   Nature Reviews Clinical Oncology

Artificial intelligence-based multi-omics analysis fuels cancer precision medicine

(2023) Xiujing He et al.   SEMINARS IN CANCER BIOLOGY

Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity

(2023) Jing Lin et al.   Nature Communications

Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example

(2023) Qi Meng et al.   Small Methods

Boosting Checkpoint Immunotherapy with Biomaterials

(2023) Lujie Liu et al.   ACS Nano

Theranostics applications of quantum dots in regenerative medicine, cancer medicine, and infectious diseases

(2023) Hiroshi Yukawa et al.   ADVANCED DRUG DELIVERY REVIEWS

Ultrasmall Coordination Polymer Nanodots Fe‐Quer Nanozymes for Preventing and Delaying the Development and Progression of Diabetic Retinopathy

(2023) Siyu Gui et al.   ADVANCED FUNCTIONAL MATERIALS

H2S‐Activated Ion‐Interference Therapy: A Novel Tumor Targeted Therapy Based on Copper‐Overload‐Mediated Cuproptosis and Pyroptosis

(2023) Fan Zhao et al.   ADVANCED FUNCTIONAL MATERIALS

Ferroptosis and Pyroptosis Co‐Activated Nanomodulator for “Cold” Tumor Immunotherapy and Lung Metastasis Inhibition

(2023) Cong Jiang et al.   ADVANCED FUNCTIONAL MATERIALS

Virus‐Like Particle‐Induced cGAS‐STING Activation and AIM2 Inflammasome‐Mediated Pyroptosis for Robust Cancer Immunotherapy

(2023) Xinyu Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glutathione‐Induced In Situ Michael Addition between Nanoparticles for Pyroptosis and Immunotherapy

(2023) Wenyao Zhen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual-stimulus phototherapeutic nanogel for triggering pyroptosis to promote cancer immunotherapy

(2023) Jiming Xu et al.   JOURNAL OF CONTROLLED RELEASE

Small-Molecule Ferritin Degrader as a Pyroptosis Inducer

(2023) Yu Chen et al.   Journal of the American Chemical Society

Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response

(2023) Mingle Li et al.   Journal of the American Chemical Society

Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment

(2023) Paolo Coghi et al.   MEDICINAL RESEARCH REVIEWS

CTLA-4 blockade induces tumor pyroptosis via CD8+ T cells in head and neck squamous cell carcinoma

(2023) Shuo Wang et al.   MOLECULAR THERAPY

Nanodrug Augmenting Antitumor Immunity for Enhanced TNBC Therapy via Pyroptosis and cGAS-STING Activation

(2023) Huihai Zhong et al.   Nano Letters

Structural mechanisms for regulation of GSDMB pore-forming activity

(2023) Xiu Zhong et al.   NATURE

Boosting Glioblastoma Therapy with Targeted Pyroptosis Induction

(2023) Xinggang Fang et al.   Small

A Mitochondria‐Targeted NIR‐II AIEgen Induced Pyroptosis for Enhanced Tumor Immunotherapy

(2023) Kaiwu Yu et al.   Advanced Healthcare Materials

Nanomaterials for Disease Treatment by Modulating the Pyroptosis Pathway

(2023) Mengzhen Wang et al.   Advanced Healthcare Materials

Enhanced mild-temperature photothermal therapy by pyroptosis-boosted ATP deprivation with biodegradable nanoformulation

(2023) Kaiyuan Liu et al.   JOURNAL OF NANOBIOTECHNOLOGY

Engineering 2D Multienzyme‐Mimicking Pyroptosis Inducers for Ultrasound‐Augmented Catalytic Tumor Nanotherapy

(2023) Xinran Song et al.   Advanced Science

Neutrophil Camouflaged Stealth Nanovehicle for Photothermal‐Induced Tumor Immunotherapy by Triggering Pyroptosis

(2023) Xuya Yu et al.   Advanced Science

Self-assembled albumin nanoparticles induce pyroptosis for photodynamic/photothermal/immuno synergistic therapies in triple-negative breast cancer

(2023) Jianquan Yang et al.   Frontiers in Immunology

Copper‐Bacteriochlorin Nanosheet as a Specific Pyroptosis Inducer for Robust Tumor Immunotherapy

(2023) Yunxiu Zhang et al.   ADVANCED MATERIALS

Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism

(2023) Binbin Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineered Bacteria Labeled with Iridium(III) Photosensitizers for Enhanced Photodynamic Immunotherapy of Solid Tumors

(2023) Wenkai Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Focused acoustic vortex-mediated sonochemotherapy for the amplification of immunogenic cell death combined with checkpoint blockade to potentiate cancer immunotherapy

(2023) Zhen Ya et al.   BIOMATERIALS

Biomimetic nanoparticle synchronizing pyroptosis induction and mitophagy inhibition for anti-tumor therapy

(2023) Yudi Deng et al.   BIOMATERIALS

An acid-responsive MOF nanomedicine for augmented anti-tumor immunotherapy via a metal ion interference-mediated pyroptotic pathway

(2023) Zhenzhen Feng et al.   BIOMATERIALS

Advances of medical nanorobots for future cancer treatments

(2023) Xiangyi Kong et al.   Journal of Hematology & Oncology

Activation of Pyroptosis Using AIEgen-Based sp2 Carbon-Linked Covalent Organic Frameworks

(2023) Liang Zhang et al.   Journal of the American Chemical Society

The therapeutic potential of targeting regulated non-apoptotic cell death

(2023) Kamyar Hadian et al.   NATURE REVIEWS DRUG DISCOVERY

Macrophages‐Based Biohybrid Microrobots for Breast Cancer Photothermal Immunotherapy by Inducing Pyroptosis

(2023) Guozheng Xing et al.   Small

Integration of AIEgens into covalent organic frameworks for pyroptosis and ferroptosis primed cancer immunotherapy

(2023) Liang Zhang et al.   Nature Communications

mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy

(2023) Fengqiao Li et al.   Nature Communications

Record‐High Ultrasound‐Sensitive NO Nanogenerators for Cascade Tumor Pyroptosis and Immunotherapy

(2023) Yuheng Bao et al.   Advanced Science

GSDME Is Related to Prognosis and Response to Chemotherapy in Oral Cancer

(2022) S. Wang et al.   JOURNAL OF DENTAL RESEARCH

Methods for monitoring cancer cell pyroptosis

(2022) Shuo Wang et al.   Cancer Biology & Medicine

Biomimetic Metal-Organic Framework Nanoparticles for Synergistic Combining of SDT-Chemotherapy Induce Pyroptosis in Gastric Cancer

(2022) Zhu Yu et al.   Frontiers in Bioengineering and Biotechnology

Research Progress and Prospects for Polymeric Nanovesicles in Anticancer Drug Delivery

(2022) Dan Li et al.   Frontiers in Bioengineering and Biotechnology

VB12-Sericin-PBLG-IR780 Nanomicelles for Programming Cell Pyroptosis via Photothermal (PTT)/Photodynamic (PDT) Effect-Induced Mitochondrial DNA (mitoDNA) Oxidative Damage

(2022) Weihong Guo et al.   ACS Applied Materials & Interfaces

Chemodynamic and Photothermal Combination Therapy Based on Dual-Modified Metal–Organic Framework for Inducing Tumor Ferroptosis/Pyroptosis

(2022) Huizi Deng et al.   ACS Applied Materials & Interfaces

Tumor Microenvironment-Responsive Yolk–Shell NaCl@Virus-Inspired Tetrasulfide-Organosilica for Ion-Interference Therapy via Osmolarity Surge and Oxidative Stress Amplification

(2022) Yang Li et al.   ACS Nano

Intravenous Delivery of Living Listeria monocytogenes Elicits Gasdmermin-Dependent Tumor Pyroptosis and Motivates Anti-Tumor Immune Response

(2022) Yao Liu et al.   ACS Nano

Intelligent Micro/nanorobot for Cancer Theragnostic

(2022) Jie Wang et al.   ADVANCED MATERIALS

Modulation of mitochondrial electron transport chain by pyroptosis nanoagonists for photoresponsive tumor destruction

(2022) Penghao Ji et al.   Nano Today

Advances in intelligent-responsive nanocarriers for cancer therapy

(2022) Mingce Tian et al.   PHARMACOLOGICAL RESEARCH

Application of lipid nanovesicle drug delivery system in cancer immunotherapy

(2022) Yinan Ding et al.   JOURNAL OF NANOBIOTECHNOLOGY

Engineering prodrug nanomicelles as pyroptosis inducer for codelivery of PI3K/mTOR and CDK inhibitors to enhance antitumor immunity

(2022) Qichao Yang et al.   Acta Pharmaceutica Sinica B

Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine

(2022) Xuan Wang et al.   Acta Pharmaceutica Sinica B

Engineered nanogels simultaneously implement HDAC inhibition and chemotherapy to boost antitumor immunity via pyroptosis

(2022) De-Run Chen et al.   Applied Materials Today

Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy

(2022) Jiakang Jin et al.   ACS Nano

Machine-designed biotherapeutics: opportunities, feasibility and advantages of deep learning in computational antibody discovery

(2022) Wiktoria Wilman et al.   BRIEFINGS IN BIOINFORMATICS

Effect of three-dimensional interstitial high-dose-rate brachytherapy with regional metastatic lymph node intensity-modulated radiation therapy in locally advanced peripheral non-small cell lung cancer: 5-year follow-up of a phase II clinical trial

(2022) L. Xiang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

TMZ magnetic temperature-sensitive liposomes-mediated magnetothermal chemotherapy induces pyroptosis in glioblastoma

(2022) Jingqing Yao et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeting micro-environmental pathways by PROTACs as a therapeutic strategy

(2022) Jing Liu et al.   SEMINARS IN CANCER BIOLOGY

Stepwise Size Shrinkage Cascade‐Activated Supramolecular Prodrug Boosts Antitumor Immunity by Eliciting Pyroptosis

(2022) Meng‐Yun Liang et al.   Advanced Science

Neisseria sicca and Corynebacterium matruchotii inhibited oral squamous cell carcinomas by regulating genome stability

(2022) Xin Shen et al.   Bioengineered

Metal Ion-Based Supramolecular Self-Assembly for Cancer Theranostics

(2022) Bing Chen et al.   Frontiers in Chemistry

Nanoscale Zeolitic Imidazolate Framework (ZIF)–8 in Cancer Theranostics: Current Challenges and Prospects

(2022) Hongxin Xie et al.   Cancers

The role of pyroptosis in modulating the tumor immune microenvironment

(2022) Jinxiang Wu et al.   Biomarker Research

Engineered Magnetic Polymer Nanoparticles Can Ameliorate Breast Cancer Treatment Inducing Pyroptosis–Starvation along with Chemotherapy

(2022) Yixuan Liu et al.   ACS Applied Materials & Interfaces

Biodegradable Metal–Organic-Frameworks-Mediated Protein Delivery Enables Intracellular Cascade Biocatalysis and Pyroptosis In Vivo

(2022) Leihou Shao et al.   ACS Applied Materials & Interfaces

pH-responsive Nanoprodrugs Combining a Src Inhibitor and Chemotherapy to Potentiate Antitumor Immunity via Pyroptosis in Head and Neck Cancer

(2022) Su-Wen Zhu et al.   Acta Biomaterialia

Biomineralized Two‐Enzyme Nanoparticles Regulated Tumor Glycometabolism Inducing Tumor Cell Pyroptosis and Robust Anti‐Tumor Immunotherapy

(2022) Sijia Zhang et al.   ADVANCED MATERIALS

Ru(II)-modified TiO2 nanoparticles for hypoxia-adaptive photo-immunotherapy of oral squamous cell carcinoma

(2022) Jia-Ying Zhou et al.   BIOMATERIALS

MOF-derived nanoporous carbons with diverse tunable nanoarchitectures

(2022) Minjun Kim et al.   Nature Protocols

Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response

(2022) Zhaoting Li et al.   Nature Communications

Immunomodulatory‐Photodynamic Nanostimulators for Invoking Pyroptosis to Augment Tumor Immunotherapy

(2022) Wei Qiu et al.   Advanced Healthcare Materials

Hypertoxic self-assembled peptide with dual functions of glutathione depletion and biosynthesis inhibition for selective tumor ferroptosis and pyroptosis

(2022) Yang Gao et al.   JOURNAL OF NANOBIOTECHNOLOGY

Quantum-Dot-Based Iron Oxide Nanoparticles Activate the NLRP3 Inflammasome in Murine Bone Marrow-Derived Dendritic Cells

(2022) Fernando Menegatti de Melo et al.   Nanomaterials

Pyroptosis Remodeling Tumor Microenvironment to Enhance Pancreatic Cancer Immunotherapy Driven by Membrane Anchoring Photosensitizer

(2022) Meng Wang et al.   Advanced Science

Engineered multifunctional nanocarriers for controlled drug delivery in tumor immunotherapy

(2022) Theodora Katopodi et al.   Frontiers in Oncology

Carrier-Free Nanoplatform via Evoking Pyroptosis and Immune Response against Breast Cancer

(2022) Lei Li et al.   ACS Applied Materials & Interfaces

Radiofrequency-Activated Pyroptosis of Bi-Valent Gold Nanocluster for Cancer Immunotherapy

(2022) Qingqing Zhang et al.   ACS Nano

The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives

(2022) Rui Sun et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanoagonist‐Mediated GSDME‐Dependent Pyroptosis Remodels the Inflammatory Microenvironment for Tumor Photoimmunotherapy

(2022) Lulu Zheng et al.   ADVANCED FUNCTIONAL MATERIALS

A Dual‐Responsive STAT3 Inhibitor Nanoprodrug Combined with Oncolytic Virus Elicits Synergistic Antitumor Immune Responses by Igniting Pyroptosis

(2022) Wen Su et al.   ADVANCED MATERIALS

Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications

(2022) Linzhou Yin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tailoring carrier-free nanocombo of small-molecule prodrug for combinational cancer therapy

(2022) Haonan Li et al.   JOURNAL OF CONTROLLED RELEASE

Induction of pyroptotic cell death as a potential tool for cancer treatment

(2022) Sara Socorro Faria et al.   Journal of Inflammation-London

Diselenide‐Based Dual‐Responsive Prodrug as Pyroptosis Inducer Potentiates Cancer Immunotherapy

(2022) Shu‐Cheng Wan et al.   Advanced Healthcare Materials

Co-delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics

(2022) Qiang Niu et al.   Acta Pharmaceutica Sinica B

Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy

(2021) Sheera R. Rosenbaum et al.   Cancer Discovery

Inspired Epigenetic Modulation Synergy with Adenosine Inhibition Elicits Pyroptosis and Potentiates Cancer Immunotherapy

(2021) Honggang Xiong et al.   ADVANCED FUNCTIONAL MATERIALS

A Virus‐Spike Tumor‐Activatable Pyroptotic Agent

(2021) Sadia Nadeem et al.   Small

Near‐Infrared II Light‐Triggered Robust Carbon Radical Generation for Combined Photothermal and Thermodynamic Therapy of Hypoxic Tumors

(2021) Xin Liu et al.   ADVANCED FUNCTIONAL MATERIALS

The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

(2021) Jia-yuan Zhang et al.   CELL RESEARCH

Biomaterials‐Based Delivery of Therapeutic Antibodies for Cancer Therapy

(2021) Qian‐Ni Ye et al.   Advanced Healthcare Materials

Pyroptosis, a new bridge to tumor immunity

(2021) Lisha Li et al.   CANCER SCIENCE

NLRP3 inflammasome activation and cell death

(2021) Yi Huang et al.   Cellular & Molecular Immunology

Three-Dimensional Covalent Organic Frameworks with Cross-Linked Pores for Efficient Cancer Immunotherapy

(2021) Liang Zhang et al.   NANO LETTERS

A Nanoplatform to Amplify Apoptosis-to-Pyroptosis Immunotherapy via Immunomodulation of Myeloid-Derived Suppressor Cells

(2021) Shiyao Zhou et al.   ACS Applied Materials & Interfaces

Bioengineering Approaches for the Advanced Organoid Research

(2021) Sang Ah Yi et al.   ADVANCED MATERIALS

Engineering Multienzyme‐Mimicking Covalent Organic Frameworks as Pyroptosis Inducers for Boosting Antitumor Immunity

(2021) Liang Zhang et al.   ADVANCED MATERIALS

Polyprodrug Nanomedicines: An Emerging Paradigm for Cancer Therapy

(2021) Kuikun Yang et al.   ADVANCED MATERIALS

A Carbonic Anhydrase IX (CAIX)‐Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti‐Tumor Immunity

(2021) Xuxian Su et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cancer immunogenic cell death via photo-pyroptosis with light-sensitive Indoleamine 2,3-dioxygenase inhibitor conjugate

(2021) Yang Lu et al.   BIOMATERIALS

Interfacial Assembly and Applications of Functional Mesoporous Materials

(2021) Linlin Duan et al.   CHEMICAL REVIEWS

Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity

(2021) Junwei Hou et al.   MOLECULAR CELL

Biodegradable Upconversion Nanoparticles Induce Pyroptosis for Cancer Immunotherapy

(2021) Binbin Ding et al.   NANO LETTERS

Inspired heat shock protein alleviating prodrug enforces immunogenic photodynamic therapy by eliciting pyroptosis

(2021) Junjie Zhou et al.   Nano Research

Near‐Infrared‐II Quantum Dots for In Vivo Imaging and Cancer Therapy

(2021) Lu‐Lu Chen et al.   Small

Microenvironment‐Responsive Prodrug‐Induced Pyroptosis Boosts Cancer Immunotherapy

(2021) Yao Xiao et al.   Advanced Science

Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

(2021) Jin Zhang et al.   Advanced Science

Machine and deep learning approaches for cancer drug repurposing

(2020) Naiem T. Issa et al.   SEMINARS IN CANCER BIOLOGY

Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

(2020) Yuying Liu et al.   Science Immunology

Metal–Organic Framework Nanoparticles Induce Pyroptosis in Cells Controlled by the Extracellular pH

(2020) Evelyn Ploetz et al.   ADVANCED MATERIALS

Immune checkpoint signaling and cancer immunotherapy

(2020) Xing He et al.   CELL RESEARCH

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

Electromagnetic nanomedicines for combinational cancer immunotherapy

(2020) Kanyi Pu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bimetallic Oxide FeWO X Nanosheets as Multifunctional Cascade Bioreactors for Tumor Microenvironment‐Modulation and Enhanced Multimodal Cancer Therapy

(2020) Fei Gong et al.   ADVANCED FUNCTIONAL MATERIALS

Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

(2020) Dan Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

(2020) Pengfei Zhao et al.   BIOMATERIALS

Nanocarrier-based Drug Delivery System for Cancer Therapeutics: A Review of the Last Decade

(2020) Muhammad Sohail et al.   CURRENT MEDICINAL CHEMISTRY

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

Engineering Prodrug Nanomedicine for Cancer Immunotherapy

(2020) Bin Yang et al.   Advanced Science

Na2S2O8 Nanoparticles Trigger Antitumor Immunotherapy through Reactive Oxygen Species Storm and Surge of Tumor Osmolarity

(2020) Yang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8+ T cells

(2019) Sjoerd T.T. Schetters et al.   Acta Biomaterialia

Covalent Organic Frameworks as Favorable Constructs for Photodynamic Therapy

(2019) Liang Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Caspases in Cell Death, Inflammation, and Disease

(2019) Nina Van Opdenbosch et al.   IMMUNITY

Boron neutron capture therapy (BNCT): a unique role in radiotherapy with a view to entering the accelerator-based BNCT era

(2019) Minoru Suzuki   International Journal of Clinical Oncology

Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells

(2019) Ping-Hsien Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gasdermins and their role in immunity and inflammation

(2019) Pontus Orning et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Atomic‐Precision Gold Clusters for NIR‐II Imaging

(2019) Haile Liu et al.   ADVANCED MATERIALS

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

(2019) Jin-Xuan Fan et al.   NANO LETTERS

Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents

(2018) Kevin J. McHugh et al.   ADVANCED MATERIALS

Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment

(2018) Kyohei Nakamura et al.   CANCER CELL

Drug delivery: DNA nanorobots — seek and destroy

(2018) Conor A. Bradley   NATURE REVIEWS DRUG DISCOVERY

Single-cell multiomics sequencing and analyses of human colorectal cancer

(2018) Shuhui Bian et al.   SCIENCE

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

CdSe/ZnS quantum dots induce hepatocyte pyroptosis and liver inflammation via NLRP3 inflammasome activation

(2016) Yonghui Lu et al.   BIOMATERIALS

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Current advances in self-assembled nanogel delivery systems for immunotherapy

(2015) Yoshiro Tahara et al.   ADVANCED DRUG DELIVERY REVIEWS

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Stimuli-responsive nanogel composites and their application in nanomedicine

(2015) Maria Molina et al.   CHEMICAL SOCIETY REVIEWS

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

(2015) Hui Gao et al.   NATURE MEDICINE

Ultrasound induced cancer immunotherapy

(2014) Johan Unga et al.   ADVANCED DRUG DELIVERY REVIEWS

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

(2014) J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

(2013) Nicolas Bertrand et al.   ADVANCED DRUG DELIVERY REVIEWS

Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments

(2013) H Inoue et al.   CELL DEATH AND DIFFERENTIATION

An active role for machine learning in drug development

(2011) Robert F Murphy   Nature Chemical Biology

Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice

(2008) Shuiping Tu et al.   CANCER CELL